Clinical profile of vitiligo patients and relationship with immuno-inflammatory markers

Mascarenhas, Marta Regina Machado; Oliveira, Mariana de Castro; Oliveira, Luise Fonseca de; Magalhães, Andréa Santos; Machado, Paulo Roberto Lima

doi:10.1016/j.abd.2023.03.007

Cited by 3 publications

(4 citation statements)

References 37 publications

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“…Furthermore, Solak et al suggested that an elevated NLR may indicate an increased cardiovascular risk in vitiligo [ 19 ]. In contrast to Solak et al, both Mascarenhes et al and Demirbaş et al did not find a significant increase in NLR levels in vitiligo patients compared to the control group [ 14 , 21 ]. However, Demirbaş et al did find a positive correlation between vitiligo severity and NLR [ 14 ].…”

Section: Discussionmentioning

confidence: 80%

“…NLR is an inflammatory hematological marker that is associated with cardiovascular morbidity and mortality [ 20 ]. Solak et al, Mascarenhas et al, and Demirbaş et al investigated the role of NLR in vitiligo [ 14 , 19 , 21 ]. Solak et al found that the NLR level was significantly higher in generalized vitiligo compared to the control and localized vitiligo groups.…”

Section: Discussionmentioning

confidence: 99%

“…NLR is an inflammatory hematological marker that is associated with cardiovascular morbidity and mortality [20]. [14,21]. However, Demirbaş et al did find a positive correlation between vitiligo severity and NLR [14].…”

Section: Discussionmentioning

confidence: 99%

“…Solak et al, Mascarenhas et al, and Demirbaş et al investigated the role of NLR in vitiligo[14,19,21].Solak et al found that the NLR level was significantly higher in generalized vitiligo compared to the control and localized vitiligo groups. However, there was no significant difference between the localized vitiligo and control groups.…”

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confidence: 99%

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An Evaluation of the Hematological Markers of Systemic Inflammation and Oxidative Stress in Vitiligo: A Case-Control Study

Temel,

Orenay,

Karaosmanoglu

2024

Cureus

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Introduction Melanocyte dysfunction in vitiligo is considered to be due to genetics, inflammation, and autoimmunity. Research has shown that oxidative stress plays a significant role in triggering these conditions. Currently, there are several markers indicating hematological inflammation and oxidative stress. This study aimed to investigate the status of inflammation and oxidative stress markers in vitiligo. Methods This study included patients with vitiligo and age-gender-matched healthy controls. C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-high-density lipoprotein ratio (MHR) and extent of vitiligo were calculated and compared. Results The study included 138 participants (69 vitiligo and 69 controls). The mean was 41.46 years with a female predominance (55.1%). The patient group demonstrated higher levels of platelets, neutrophils, CRP, NLR, MLR, PLR, and HDL and lower levels of lymphocytes and HDL compared to the control group (p>0,05). The only significantly different value between the groups was MHR (p=0.03). The generalized vitiligo group demonstrated higher levels of platelets, neutrophils, monocytes, CRP, NLR, PLR, and MLR, and lower levels of lymphocytes and HDL compared to the localized group. The only significantly different values between the groups were MHR and MLR (p=0.02, p=0.03). Conclusion This study found that MHR and CRP values were higher in vitiligo patients. Additionally, MHR and MLR values were higher in patients with generalized vitiligo. These results suggest that MHR is a reliable indicator marker for systemic inflammation and oxidative stress in vitiligo.

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Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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An Evaluation of the Hematological Markers of Systemic Inflammation and Oxidative Stress in Vitiligo: A Case-Control Study

Temel,

Orenay,

Karaosmanoglu

2024

Cureus

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Harnessing the Targeting Potential of Nano-biomaterials to Treat Autoimmune Skin Disorders

Gnanakani,

Kirubakaran,

Rama

et al. 2024

Biomaterial-Inspired Nanomedicines for Targeted Therapies

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Markers of Metabolic Abnormalities in Vitiligo Patients

Papaccio,

Ottaviani,

Truglio

et al. 2024

IJMS

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While vitiligo is primarily caused by melanocyte deficiency or dysfunction, recent studies have revealed a notable prevalence of metabolic syndrome (MetS) among patients with vitiligo. This suggests shared pathogenic features between the two conditions. Individuals with vitiligo often exhibit variations in triglyceride levels, cholesterol, and blood pressure, which are also affected in MetS. Given the similarities in their underlying mechanisms, genetic factors, pro-inflammatory signalling pathways, and increased oxidative stress, this study aims to highlight the common traits between vitiligo and metabolic systemic disorders. Serum analyses confirmed increased low-density lipoprotein (LDL) levels in patients with vitiligo, compared to physiological values. In addition, we reported significant decreases in folate and vitamin D (Vit D) levels. Oxidative stress is one of the underlying causes of the development of metabolic syndromes and is related to the advancement of skin diseases. This study found high levels of inflammatory cytokines, such as interleukin-6 (IL-6) and chemokine 10 (CXCL10), which are markers of inflammation and disease progression. The accumulation of insulin growth factor binding proteins 5 (IGFBP5) and advanced glycation end products (AGEs) entailed in atherosclerosis and diabetes onset, respectively, were also disclosed in vitiligo. In addition, the blood-associated activity of the antioxidant enzymes catalase (Cat) and superoxide dismutase (SOD) was impaired. Moreover, the plasma fatty acid (FAs) profile analysis showed an alteration in composition and specific estimated activities of FAs biosynthetic enzymes resembling MetS development, resulting in an imbalance towards pro-inflammatory n6-series FAs. These results revealed a systemic metabolic alteration in vitiligo patients that could be considered a new target for developing a more effective therapeutic approach.

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Clinical profile of vitiligo patients and relationship with immuno-inflammatory markers

Cited by 3 publications

References 37 publications

An Evaluation of the Hematological Markers of Systemic Inflammation and Oxidative Stress in Vitiligo: A Case-Control Study

An Evaluation of the Hematological Markers of Systemic Inflammation and Oxidative Stress in Vitiligo: A Case-Control Study

Harnessing the Targeting Potential of Nano-biomaterials to Treat Autoimmune Skin Disorders

Markers of Metabolic Abnormalities in Vitiligo Patients

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