Clinical Presentations and Outcomes Related to Tuberculosis in Children Younger Than 2 Years of Age in Catalonia

Soriano‐Arandes, Antoni; Brugueras, Sílvia; Chitiva, Alejandro Rodríguez; Noguera-Julián, Antoni; Orcau, Àngels; Martin‐Nalda, Andrea; Millet, Joan Pau; Vallmanya, Teresa; Méndez, María Luaces; Coll-Sibina, Maite; Mayol, Luis; Clopés, Asumpció; Pineda, Valentı́; García, Lourdes; López, Núria; Calavia, Olga; Rius, Neus; Pérez-Porcuna, Tomàs; Soler‐Palacín, Pere; Caylà, Joan A.

doi:10.3389/fped.2019.00238

Cited by 9 publications

(4 citation statements)

References 31 publications

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“…In fact, adolescents are a key target group for TB control interventions, since, as stated by the WHO, adolescents are more often contagious and have a larger number of contacts in closed spaces such as schools [ 24 ]. It is also remarkable that children under 5 years of age were the only age group in which the percentage of hospitalizations exceeds that of reported cases, probably because children, especially those under 2 years of age, have more acute symptoms with more severe forms and a higher complication rate [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

The epidemiological situation of tuberculosis in Spain according to surveillance and hospitalization data, 2012–2020

Pedraz,

Herrera,

Vazquez

et al. 2024

PLoS ONE

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Background Before the COVID-19 pandemic, tuberculosis (TB) was the leading cause of death from a single infectious agent. In Spain, TB notifications are registered through the National Epidemiological Surveillance Network (RENAVE). The Minimum Basic Data Set (CMBD) provides information on TB hospital discharges. This study aims to assess both registries to complete the picture of TB in order to improve national control strategies and make further progress toward its elimination. Methods A retrospective study was performed considering CMBD´s hospital discharges with TB as first diagnosis and notifications to RENAVE between 2012 and 2020. After describing the records of both systems and their differences by using descriptive and multivariate analysis, annual incidences rates were calculated in order to evaluate temporal trends and geographical patters. Results According to the CMBD database, there were 29,942 hospitalizations due to TB (65% pulmonary forms and 66% male) during the study period. RENAVE collected 44,520 reported cases, mostly males (62%) with pulmonary forms (72%). Young children were similar in both groups, showing the high frequency of hospitalization in this group. Almost all autonomous communities showed a downward trend, especially Asturias. Hospitalizations in 2020 were analyzed by month separately, and comparing with previous years, the impact of the COVID-19 pandemic can be seen. Conclusions A decreasing trend on TB incidence was observed in Spain since 2012, although this trend might change after COVID-19 pandemic. The analysis of both databases, CMBD and RENAVE, has contributed to improve our knowledge of TB in Spain and will help improve the control of this disease.

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Section: Discussionmentioning

confidence: 99%

The epidemiological situation of tuberculosis in Spain according to surveillance and hospitalization data, 2012–2020

Pedraz,

Herrera,

Vazquez

et al. 2024

PLoS ONE

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“…A recent study has shown a 10-15% rise in DR-EPTB [ 157 ]. EPTB is less reported in children than in pulmonary tuberculosis (PTB) [ 154 , 158 - 160 ]. It has a higher incidence of MDR-TB [ 156 , 161 ].…”

Section: Reviewmentioning

confidence: 99%

Multidrug-Resistant TB (MDR-TB) and Extensively Drug-Resistant TB (XDR-TB) Among Children: Where We Stand Now

Chowdhury¹,

Ahmad²,

Sinha³

et al. 2023

Cureus

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Drug-resistant tuberculosis (DR-TB) has continued to be a global health cataclysm. It is an arduous condition to tackle but is curable with the proper choice of drug and adherence to the drug therapy. WHO has introduced newer drugs with all-oral shorter regimens, but the COVID-19 pandemic has disrupted the achievements and raised the severity. The COVID-19 controlling mechanism is based on social distancing, using face masks, personal protective equipment, medical glove, head shoe cover, face shield, goggles, hand hygiene, and many more. Around the globe, national and international health authorities impose lockdown and movement control orders to ensure social distancing and prevent transmission of COVID-19 infection. Therefore, WHO proposed a TB control program impaired during a pandemic. Children, the most vulnerable group, suffer more from the drug-resistant form and act as the storehouse of future fatal cases. It has dire effects on physical health and hampers their mental health and academic career. Treatment of drug-resistant cases has more success stories in children than adults, but enrollment for treatment has been persistently low in this age group. Despite that, drug-resistant childhood tuberculosis has been neglected, and proper surveillance has not yet been achieved. Insufficient reporting, lack of appropriate screening tools for children, less accessibility to the treatment facility, inadequate awareness, and reduced funding for TB have worsened the situation. All these have resulted in jeopardizing our dream to terminate this deadly condition. So, it is high time to focus on this issue to achieve our Sustainable Development Goals (SDGs), the goal of ending TB by 2030, as planned by WHO. This review explores childhood TB's current position and areas to improve. This review utilized electronic-based data searched through PubMed, Google Scholar, Google Search Engine, Science Direct, and Embase.

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“…Hal tersebut sejalan dengan penelitian Tebandite K, dkk. ditemukan adanya anak yang sebelumnya masuk kategori BB normal mengalami penurunan BB dan masuk kategori BB kurang selama dilakukan terapi (12). Terbukti di dalam penelitian Kant S, dkk.…”

Section: Tabel 2 Hasil Pengujian Hipotesisunclassified

“…Pada penelitian Tebandite K, dkk. juga menghasilkan perbedaan statistik yang signifikan antara sebelum dan sesudah terapi OAT (12).…”

Section: Tabel 2 Hasil Pengujian Hipotesisunclassified

Status Gizi Pasien Tuberkulosis Paru pada Anak Sebelum dan Sesudah Terapi Obat Anti Tuberkulosis (OAT)

Surahman¹,

Sekarwana²,

Wardani³

2023

BCSMS

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Abstract. Nutritional status in pediatric tuberculosis (TB) patients plays an important role in the course of TB disease. After being given appropriate TB therapy, the infection process begins to decrease and there is an increase in the formation of fatty acids and a decrease in the process of lipolysis in the tissues. The purpose of this study was to analyze the differences in the nutritional status of pulmonary tuberculosis patients in children before and after therapy at the Children's Polyclinic at Al-Islam Hospital Bandung in 2019 – 2020. The research subjects were children with pulmonary TB aged 0 – 4 years who had completed therapy and were selected using a purposive sampling technique. This study used an analytic observational method with a cross-sectional design. Data on body weight (BB) and age were obtained from medical records and grouped into three categories of nutritional status. The number of samples in this study was 67 children with pulmonary TB. The results of the study showed that before TB therapy, 26 (39%) people had poor nutritional status, 40 (60%) people had normal nutritional status, and only one (1%) person had a risk of being overweight. After therapy, 13 (19%) people had underweight nutritional status, 50 (75%) normal weight nutritional status, and four (6%) people had a risk of being overweight. The results showed that there were significant differences in the nutritional status of children before and after TB therapy (p 0.001; <0.05). In conclusion, there are significant differences regarding the nutritional status of pulmonary tuberculosis patients in children before and after therapy. Keywords: Pediatric tuberculosis, nutritional status, therapy. Abstrak. Status gizi pada pasien tuberkulosis (TB) anak berperan penting dalam perjalanan penyakit TB. Setelah diberikan terapi TB yang tepat maka proses infeksi mulai berkurang dan terjadi peningkatan pembentukkan asam lemak dan penurunan proses lipolisis di jaringan. Tujuan penelitian ini adalah menganalisis perbedaan status gizi pasien tuberkulosis paru pada anak sebelum dan sesudah terapi di Poli Anak Rumah Sakit Al – Islam Bandung tahun 2019 – 2020. Subjek penelitian adalah anak penderita TB paru berusia 0 – 4 tahun yang telah menyelesaikan terapi dan dipilih menggunakan teknik purposive sampling. Penelitian ini menggunakan metode observasional analitik dengan desain cross sectional. Data berat badan (BB) dan usia diperoleh dari rekam medis dan dikelompokkan menjadi tiga kategori status gizi. Jumlah sampel penelitian ini adalah 67 penderita TB paru anak. Hasil penelitian didapatkan bahwa sebelum dilakukan terapi TB 26 (39%) orang memiliki status gizi BB kurang, 40 (60%) orang berstatus gizi BB normal, dan hanya satu (1%) orang yang memiliki risiko BB lebih. Sesudah dilakukan terapi sebanyak 13 (19%) orang memiliki status gizi BB kurang, sebanyak 50 (75%) berstatus gizi BB normal, dan empat (6%) orang memiliki risiko BB lebih. Hasil penelitian menunjukkan terdapat perbedaan yang signifikan pada status gizi anak sebelum dan sesudah dilakukan terapi TB (p 0,001; <0,05). Simpulan, terdapat perbedaan yang signifikan terkait status gizi pasien tuberkulosis paru pada anak sebelum dan sesudah terapi. Kata Kunci: Tuberkulosis anak, status gizi, terapi.

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Clinical Presentations and Outcomes Related to Tuberculosis in Children Younger Than 2 Years of Age in Catalonia

Cited by 9 publications

References 31 publications

The epidemiological situation of tuberculosis in Spain according to surveillance and hospitalization data, 2012–2020

The epidemiological situation of tuberculosis in Spain according to surveillance and hospitalization data, 2012–2020

Multidrug-Resistant TB (MDR-TB) and Extensively Drug-Resistant TB (XDR-TB) Among Children: Where We Stand Now

Status Gizi Pasien Tuberkulosis Paru pada Anak Sebelum dan Sesudah Terapi Obat Anti Tuberkulosis (OAT)

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