Clinical pattern of ocular toxoplasmosis treated in a referral centre in Serbia

Kovačević-Pavićević, Dragana; Radosavljević, Aleksandra; Ilić, Aleksandra; Kovačević, Igor; Djurković–Djaković, Olgica

doi:10.1038/eye.2012.20

Cited by 17 publications

(16 citation statements)

References 29 publications

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“…As shown in our study, out of a total of 80 eyes with ocular toxoplasmosis with SD-OCT examinations, 6 eyes were present with CME. Although with the application of SD-OCT, more eyes with CME probably could have been detected, our study had shown that CME is still rather uncommon [14] , [15] , [16] .…”

Section: Discussionmentioning

confidence: 57%

“…FA has been the traditional gold standard for the detection of CME in the past years; however, with the advent of OCT, more CME could be possibly observed with better reproducibility [8], [13]. Although CME in ocular toxoplasmosis was reported in previous publications, none of them evaluated CME with SD-OCT [14], [15], [16]. Thus, in the current study, we tried to use SD-OCT to maximize the detection of CME.…”

Section: Discussionmentioning

confidence: 98%

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Evaluation of Cystoid Change Phenotypes in Ocular Toxoplasmosis Using Optical Coherence Tomography

et al. 2014

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PurposeTo present unique cystoid changes occurring in patients with ocular toxoplasmosis observed in spectral domain optical coherence tomography (OCT).MethodsForty-six patients (80 eyes) with a diagnosis of ocular toxoplasmosis, who underwent volume OCT examination between January 2005 and October 2012, were retrospectively collected. Review of clinical examination findings, fundus photographs, fluorescein angiograms (FA) and OCT image sets obtained at initial visits and follow-up. Qualitative and quantitative analyses of cystoid space phenotypes visualized using OCT.ResultsOf the 80 eyes included, 17 eyes (15 patients) demonstrated cystoid changes in the macula on OCT. Six eyes (7.5%) had cystoid macular edema (CME), 2 eyes (2.5%) had huge outer retinal cystoid space (HORC), 12 eyes (15%) had cystoid degeneration and additional 3 eyes (3.75%) had outer retinal tubulation due to age related macular degeneration. In one eye with HORC, the lesion was seen in the photoreceptor outer segment, accompanied by photoreceptor elongation and splitting. Three eyes presented with paravascular cystoid degeneration in the inner retina without other macular OCT abnormality.ConclusionsIn this study, different phenotypes of cystoid spaces seen in eyes with ocular toxoplasmosis using spectral domain OCT (SD-OCT) were demonstrated. CME presented as an uncommon feature, consistently with previous findings. Identification of rare morphological cystoid features (HORC with/without photoreceptor enlongation or splitting) on clinical examination had provided evidence to previous experimental models, which may also expand the clinical spectrum of the disease. Cystoid degeneration in the inner retina next to the retinal vessels in otherwise “normal” looking macula was observed, which may suggest more often clinical evaluation for those patients. Further studies are needed to verify the relevance of cystoid features seen on SD-OCT in assisting with the diagnosis and management of ocular toxoplasmosis.

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 98%

Evaluation of Cystoid Change Phenotypes in Ocular Toxoplasmosis Using Optical Coherence Tomography

et al. 2014

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“…Toxoplasmosis is the most common cause of infectious posterior uveitis worldwide leading to severe vision loss, [1][2][3][4] although there is some evidence of decline in its prevalence in certain areas. [5] Ocular toxoplasmosis (OT) refers to eye disease related to infection from the obligate intracellular parasite Toxoplasma gondii.…”

Section: Introductionmentioning

confidence: 99%

Ocular toxoplasmosis: phenotype differences between toxoplasma IgM positive and IgM negative patients in a large cohort

et al. 2020

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PurposeTo investigate the differences in demographics and clinical characteristics of patients diagnosed with ocular toxoplasmosis according to their IgM status.MethodsRetrospective case note analysis was carried out on patients who tested positive for serum Toxoplasma gondii-specific IgM antibodies (IgM+) as well as a comparator group who tested negative for serum IgM (IgM-), but positive for serum IgG. Patient demographics and clinical features were compared between the two groups to evaluate for any significant differences.ResultsOne hundred and six patients were included in the study between March 2011 and June 2018, consisting of 37 in the IgM +group and 69 in the IgM- group. Patients in the IgM +group were significantly older (51.1 vs 34.1 years, p<0.0001), more likely to present with central macular lesions (32% vs 12%, p=0.012), and more likely to develop rhegmatogenous retinal detachment (11% vs 1%, p=0.049). In contrast, patients in the IgM- group were more likely present with pain (20% vs 3%, 0.017) and exhibit more severe inflammation of the anterior chamber and vitreous (p<0.05). Overall, retinal lesions were more likely to be superotemporal (55%) and superonasal (31%). Furthermore, age was associated with larger (p=0.003) and more peripheral lesions (p=0.007).ConclusionsThis study demonstrated significant differences in clinical characteristics of ocular toxoplasmosis according to serum IgM status. IgM+ patients were older, less likely to report pain, had lower levels of intraocular inflammation, but were more likely to have macular involvement. We also found age to be correlated with larger and more peripheral lesions.

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“…Cells in the anterior chamber may also be noted and may appear to be either a granulomatous or non granulomatous uveitis. The discovery of healed pigmented retinochoroidal scars facilitates the diagnosis [57,58]. OT is also confirmed by a favorable clinical response to specific therapy.…”

Section: Diagnosis Is Based On Clinical Signs and Some Selected Biolomentioning

confidence: 79%

Risk Factors, Pathogenesis and Diagnosis of Ocular Toxoplasmosis

Dupouy‐Camet¹,

Talabani²,

Delair³

et al. 2012

Toxoplasmosis - Recent Advances

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Clinical pattern of ocular toxoplasmosis treated in a referral centre in Serbia

Cited by 17 publications

References 29 publications

Evaluation of Cystoid Change Phenotypes in Ocular Toxoplasmosis Using Optical Coherence Tomography

Evaluation of Cystoid Change Phenotypes in Ocular Toxoplasmosis Using Optical Coherence Tomography

Ocular toxoplasmosis: phenotype differences between toxoplasma IgM positive and IgM negative patients in a large cohort

Risk Factors, Pathogenesis and Diagnosis of Ocular Toxoplasmosis

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