Clinical, pathological and thin-section CT features of persistent multiple ground-glass opacity nodules: Comparison with solitary ground-glass opacity nodule

Kim, Tae Jung; Goo, Jin Mo; Lee, Kyungwon; Park, Chang Min; Lee, Hyun Ju

doi:10.1016/j.lungcan.2008.08.002

Cited by 95 publications

(73 citation statements)

References 35 publications

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“…12,[23][24][25][26][27][28][29] This observation is made in both Asian and North American populations. The proportion of nonsmokers (30-80%) varies with the regional prevalence of smoking but is always greater than that of the general prevalence in patients with lung cancer in that region.…”

Section: Descriptive Characteristicsmentioning

confidence: 78%

“…Studies involving primarily solitary sub-solid nodules note that lesions are reported as adenocarcinoma (with BAC features) in ~10% (7-30%) of pure GGN and ~50% (15-80%) of part-solid (>50% ground glass) lesions. 11,23,31,[33][34][35][36][37][38][39][40][41][42] Thus, while there is a general trend, radiographic findings do not correlate well with the histologic diagnosis. To an extent this suboptimal correlation may reflect ambiguities in the histologic terms (i.e.…”

Section: Descriptive Characteristicsmentioning

confidence: 99%

See 1 more Smart Citation

The IASLC Lung Cancer Staging Project: Background Data and Proposals for the Application of TNM Staging Rules to Lung Cancer Presenting as Multiple Nodules with Ground Glass or Lepidic Features or a Pneumonic Type of Involvement in the Forthcoming Eighth Edition of the TNM Classification

Detterbeck

Marom

Arenberg

et al. 2016

Journal of Thoracic Oncology

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152

105

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For multifocal ground glass/lepidic tumors, we propose that the T category be determined by the highest T lesion, with either the number of tumors or m in parentheses to denote the multifocal nature, and that a single N and M category be used for all the lesions collectively-for example, T1a(3)N0M0 or T1b(m)N0M0. For diffuse pneumonic-type lung cancer we propose that the T category be designated by size (or T3) if in one lobe, as T4 if involving an ipsilateral different lobe, or as M1a if contralateral and that a single N and M category be used for all pulmonary areas of involvement.

show abstract

Section: Descriptive Characteristicsmentioning

confidence: 78%

Section: Descriptive Characteristicsmentioning

confidence: 99%

The IASLC Lung Cancer Staging Project: Background Data and Proposals for the Application of TNM Staging Rules to Lung Cancer Presenting as Multiple Nodules with Ground Glass or Lepidic Features or a Pneumonic Type of Involvement in the Forthcoming Eighth Edition of the TNM Classification

Detterbeck

Marom

Arenberg

et al. 2016

Journal of Thoracic Oncology

Self Cite

152

105

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“…119,137,[141][142][143][144] As is true for pure ground glass nodules, larger partsolid nodules are more likely to be malignant and invasive than smaller part-solid nodules. [138][139][140]143,[145][146][147] Clinical, pathologic, radiographic, and molecular features of pulmonary adenocarcinoma and its precursor lesions have been described in a recently revised classifi cation scheme. 148 Although attenuation characteristics and size are potentially helpful guides to predicting malignancy, some studies have reported counterintuitive results.…”

Section: E111smentioning

confidence: 99%

Evaluation of Individuals With Pulmonary Nodules: When Is It Lung Cancer?

Gould

Donington

Lynch

et al. 2013

Chest

1,072

1,022

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we suggest that no additional diagnostic evaluation need be performed (Grade 2C) .Remark : This recommendation applies only to solid nodules. For guidance about follow-up of subsolid nodules, see Recommendations 6.5.1 to 6.5.4 . 2.3.3.In the individual with an indeterminate nodule that is identifi ed by chest radiography, we recommend that CT of the chest should be performed (preferably with thin sections Objectives: The objective of this article is to update previous evidence-based recommendations for evaluation and management of individuals with solid pulmonary nodules and to generate new recommendations for those with nonsolid nodules. Methods: We updated prior literature reviews, synthesized evidence, and formulated recommendations by using the methods described in the "Methodology for Development of Guidelines for Lung Cancer" in the American College of Chest Physicians Lung Cancer Guidelines, 3rd ed. Results: We formulated recommendations for evaluating solid pulmonary nodules that measure . 8 mm in diameter, solid nodules that measure Յ 8 mm in diameter, and subsolid nodules. The recommendations stress the value of assessing the probability of malignancy, the utility of imaging tests, the need to weigh the benefi ts and harms of different management strategies (nonsurgical biopsy, surgical resection, and surveillance with chest CT imaging), and the importance of eliciting patient preferences. Conclusions: Individuals with pulmonary nodules should be evaluated and managed by estimating the probability of malignancy, performing imaging tests to better characterize the lesions, evaluating the risks associated with various management alternatives, and eliciting their preferences for management. CHEST 2013; 143(5)(Suppl):e93S-e120SAbbreviations: AAH 5 atypical adenomatous hyperplasia; ACCP 5 American College of Chest Physicians; AIS 5 adenocarcinoma in situ; EBUS 5 endobronchial ultrasound; ENB 5 electromagnetic navigation bronchoscopy; FDG 5 fl uorodeoxyglucose; HU 5 Hounsfi eld unit; LR 5 likelihood ratio; SPECT 5 single-photon emission CT; TBB 5 transbronchial biopsy; TTNB 5 transthoracic needle biopsy; VATS 5 video-assisted thoracic surgery; VBN 5 virtual bronchoscopy navigation; VDT 5 volume doubling time

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“…Compared with previous reports estimating that 0.8% to 4% of patients with lung cancer present with or develop multiple lesions, more recent data indicate that up to 20% of patients in screening populations will be diagnosed with multiple synchronous or metachronous tumors. [1][2][3][4][5][6][7][8][9] The question of whether multiple lesions represent true metastases versus independent primary lesions remains a difficult clinical problem. This distinction typically represents the difference between aggressive local therapy for patients deemed to have independent primary tumors versus less aggressive or even palliative systemic therapy for patients thought to have metastatic disease.…”

Section: Introductionmentioning

confidence: 99%

Identification of Independent Primary Tumors and Intrapulmonary Metastases Using DNA Rearrangements in Non–Small-Cell Lung Cancer

Murphy

Aubry

Harris

et al. 2014

JCO

107

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Purpose Distinguishing independent primary tumors from intrapulmonary metastases in non–small-cell carcinoma remains a clinical dilemma with significant clinical implications. Using next-generation DNA sequencing, we developed a chromosomal rearrangement–based approach to differentiate multiple primary tumors from metastasis. Methods Tumor specimens from patients with known independent primary tumors and metastatic lesions were used for lineage test development, which was then applied to multifocal tumors. Laser capture microdissection was performed separately for each tumor. Genomic DNA was isolated using direct in situ whole-genome amplification methodology, and next-generation sequencing was performed using an Illumina mate-pair library protocol. Sequence reads were mapped to the human genome, and primers spanning the fusion junctions were used for validation polymerase chain reaction. Results A total of 41 tumor samples were sequenced (33 adenocarcinomas [ADs] and eight squamous cell carcinomas [SQCCs]), with a range of three to 276 breakpoints per tumor identified. Lung tumors predicted to be independent primary tumors based on different histologic subtype did not share any genomic rearrangements. In patients with lung primary tumors and paired distant metastases, shared rearrangements were identified in all tumor pairs, emphasizing the patient specificity of identified breakpoints. Multifocal AD and SQCC samples were reviewed independently by two pulmonary pathologists. Concordance between histology and genomic data occurred in the majority of samples. Discrepant tumor samples were resolved by genome sequencing. Conclusion A diagnostic lineage test based on genomic rearrangements from mate-pair sequencing demonstrates promise for distinguishing independent primary from metastatic disease in lung cancer.

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Clinical, pathological and thin-section CT features of persistent multiple ground-glass opacity nodules: Comparison with solitary ground-glass opacity nodule

Cited by 95 publications

References 35 publications

The IASLC Lung Cancer Staging Project: Background Data and Proposals for the Application of TNM Staging Rules to Lung Cancer Presenting as Multiple Nodules with Ground Glass or Lepidic Features or a Pneumonic Type of Involvement in the Forthcoming Eighth Edition of the TNM Classification

The IASLC Lung Cancer Staging Project: Background Data and Proposals for the Application of TNM Staging Rules to Lung Cancer Presenting as Multiple Nodules with Ground Glass or Lepidic Features or a Pneumonic Type of Involvement in the Forthcoming Eighth Edition of the TNM Classification

Evaluation of Individuals With Pulmonary Nodules: When Is It Lung Cancer?

Identification of Independent Primary Tumors and Intrapulmonary Metastases Using DNA Rearrangements in Non–Small-Cell Lung Cancer

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