Clinical panel assessment of photodamaged skin treated with isotretinoin using photographs

Armstrong, R. B.

doi:10.1001/archderm.128.3.352

Cited by 16 publications

(15 citation statements)

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“…Three groups have performed large (n = 776, n = 326, and n = 800) double-blind, vehicle-controlled, randomized trials using 0.1% cream for 9 months. [47][48][49] All demonstrated statistically significant clinical improvement in wrinkling pigmentation, sallowness, and texture compared with controls starting at 12 weeks. However, no significant changes were found in the dermis in terms of elastosis reduction or fibroblast density.…”

Section: Clinical Evidencementioning

confidence: 91%

Reversal of Skin Aging with Topical Retinoids

Hubbard

Unger²,

Rohrich

2014

Plastic &Amp; Reconstructive Surgery

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Topical skin care and its place in plastic surgery today are often overlooked by clinicians formulating a plan for facial rejuvenation. Not only is it important to consider topical skin care as part of comprehensive care, but clinicians should also be educated with the data available in today's literature. This review aims to familiarize the reader with the biological processes of skin aging and evidence-based clinical outcomes afforded by various topical therapies. Furthermore, this review will focus on solar damage, the value of retinoids, and how they can be used in conjunction with forms of treatment such as chemical peel, dermabrasion, and lasers. Finally, guidelines will be provided to help the physician administer appropriate skin care based on the data presented.

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Section: Clinical Evidencementioning

confidence: 91%

Reversal of Skin Aging with Topical Retinoids

Hubbard

Unger²,

Rohrich

2014

Plastic &Amp; Reconstructive Surgery

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“…Isotretinoin-treated patients showed statistically significant improvement in the various symptoms of photoaging like fine wrinkles and pigmentation as compared with placebo-treated subjects (Cunningham 1990). Later, in 2 separate studies, the potential of isotretinoin in treating patients suffering from mild to moderate photodamage was evaluated by Sendagorta and colleagues (1992) (n = 776) and Armstrong and colleagues (1992) (n = 326) in double-blind, vehicle-controlled clinical trials. In both studies, isotretinoin cream 0.05% was applied for 12 weeks, followed by application of higher strength isotretinoin (0.1% cream) during the next 24 weeks.…”

Section: Tretinoinmentioning

confidence: 99%

“…In both studies, isotretinoin cream 0.05% was applied for 12 weeks, followed by application of higher strength isotretinoin (0.1% cream) during the next 24 weeks. Interestingly, both studies resulted in a statistically significant improvement in overall appearance, fine wrinkling, discrete pigmentation, sallowness, and texture of photoaged skin without causing any significant irritation (Armstrong et al 1992; Sendagorta et al 1992). …”

Section: Tretinoinmentioning

confidence: 99%

Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety

Mukherjee¹,

Date²,

Patravale³

et al. 2006

Clinical Interventions in Aging

399

318

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Aging of skin is an intricate biological process consisting of two types. While intrinsic or chronological aging is an inevitable process, photoaging involves the premature aging of skin occurring due to cumulative exposure to ultraviolet radiation. Chronological and photoaging both have clinically differentiable manifestations. Various natural and synthetic retinoids have been explored for the treatment of aging and many of them have shown histological and clinical improvement, but most of the studies have been carried out in patients presenting with photoaged skin. Amongst the retinoids, tretinoin possibly is the most potent and certainly the most widely investigated retinoid for photoaging therapy. Although retinoids show promise in the treatment of skin aging, irritant reactions such as burning, scaling or dermatitis associated with retinoid therapy limit their acceptance by patients. This problem is more prominent with tretinoin and tazarotene whereas other retinoids mainly represented by retinaldehyde and retinol are considerably less irritating. In order to minimize these side effects, various novel drug delivery systems have been developed. In particular, nanoparticles have shown a good potential in improving the stability, tolerability and efficacy of retinoids like tretinoin and retinol. However, more elaborate clinical studies are required to confirm their advantage in the delivery of topical retinoids.

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“…40,41 Three subsequent studies found that a once-daily application of 0.1% isotretinoin (an isomer of retinoic acid) cream for 36 weeks was effective in reducing fine wrinkles; in two of these studies a 0.05% cream had similar efficacy. [42][43][44] Three large-scale clinical trials investigating the efficacy of topical 0.1% tazarotene cream have uniformly supported its effectiveness in minimizing fine wrinkles and mottled hyperpigmentation. [45][46][47] One of these trials compared 4 different concentrations (0.1%, 0.05%, 0.025%, 0.01%) of tazarotene cream with 0.05% tretinoin cream.…”

Section: Vitamins As Therapymentioning

confidence: 99%