Clinical Outcomes of Mesenchymal Stem Cell Injection With Arthroscopic Treatment in Older Patients With Osteochondral Lesions of the Talus

Kim, Yong Sang; Park, Eui Hyun; Kim, Yong Chan; Koh, Yong‐Gon

doi:10.1177/0363546513479018

Cited by 89 publications

(93 citation statements)

References 70 publications

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“…Interesting results were also reported from a clinical trial involving older patients (mean age 57 years) using BM-MSC treatment (Kim et al. 2013). The improvement was better in patients with large lesions.…”

Section: Methodsmentioning

confidence: 99%

Cartilage repair in the degenerative ageing knee

et al. 2016

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Background and purposeCartilage damage can develop due to trauma, resulting in focal chondral or osteochondral defects, or as more diffuse loss of cartilage in a generalized organ disease such as osteoarthritis. A loss of cartilage function and quality is also seen with increasing age. There is a spectrum of diseases ranging from focal cartilage defects with healthy surrounding cartilage to focal lesions in degenerative cartilage, to multiple and diffuse lesions in osteoarthritic cartilage. At the recent Aarhus Regenerative Orthopaedics Symposium (AROS) 2015, regenerative challenges in an ageing population were discussed by clinicians and basic scientists. A group of clinicians was given the task of discussing the role of tissue engineering in the treatment of degenerative cartilage lesions in ageing patients. We present the outcomes of our discussions on current treatment options for such lesions, with particular emphasis on different biological repair techniques and their supporting level of evidence.Results and interpretationBased on the studies on treatment of degenerative lesions and early OA, there is low-level evidence to suggest that cartilage repair is a possible treatment for such lesions, but there are conflicting results regarding the effect of advanced age on the outcome. We concluded that further improvements are needed for direct repair of focal, purely traumatic defects before we can routinely use such repair techniques for the more challenging degenerative lesions. Furthermore, we need to identify trigger mechanisms that start generalized loss of cartilage matrix, and induce subchondral bone changes and concomitant synovial pathology, to maximize our treatment methods for biological repair in degenerative ageing joints.

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Section: Methodsmentioning

confidence: 99%

Cartilage repair in the degenerative ageing knee

et al. 2016

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“…Stem cells derived from fat have a better potential for chondrogenesis 58 ; those obtained from the synovium apparently have good differentiation into chondrocytes, but only in animal studies 59 …”

Section: Prognostic Factorsmentioning

confidence: 99%

Diagnosis and treatment of osteochondral lesions of the ankle: current concepts

Prado

Kennedy

Raduan

et al. 2016

Revista Brasileira de Ortopedia (English Edition)

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“…Therefore, the use of the stromal vascular fraction itself, which contains a small, but significant proportion of ASCs, may be the best available therapeutic option within a single surgical setting at this point in time. This has resulted in contention in some recent papers that purported the use of ASCs/MSCs in the treatment of chondral lesions, when a processed lipoaspirate was actually injected into the joints [55–57]. The clinical effects of using pure ASCs may in fact be very different than the use of the SVF.…”

Section: Asc Isolationmentioning

confidence: 99%

“…Current data involving the treatment of cartilaginous lesions in humans with ASCs is limited by size and study type [23–25, 48, 55, 66–72]. To the best of our knowledge, an exhaustive list of clinical studies using adipose-derived stem cells for cartilage repair is presented in Table 1.…”

Section: Human Trials Of Ascs For Chondral Lesionsmentioning

confidence: 99%

Regenerative Engineering of Cartilage Using Adipose-Derived Stem Cells

Kasir

Vernekar

Laurencin

2015

Regen. Eng. Transl. Med.

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Injury to the articular cartilage occurs commonly in the general population and undergoes minimal spontaneous healing. Traditional methods of cartilage repair provide no long-term cure and are significant causes of morbidity. For this reason, stem cell therapies have recently been investigated for their ability to regenerate cartilage, and the results have been promising. Since the discovery that adipose tissue is a major source of mesenchymal stem cells in 2001, scientists have been studying the use of adipose-derived stem cells (ASCs) for the treatment of various disorders including lesions of the articular cartilage. ASCs hold several advantages over autologous chondrocytes for cartilage repair, including but not limited to their anti-inflammatory effects, their multi-lineage differentiation potential, and their ability to form new cartilage in a defect. Whereas several investigations have been made in in vitro and animal models, there have been surprisingly little clinical studies on the intra-articular use of adipose-derived stem cells, despite their first isolation about a decade and a half ago. The few studies that have been conducted are encouraging. With approval for various stem cell therapies on the horizon, this review seeks to update the clinician and the researcher on the current state-of-the-art use of adipose-derived stem cells for the treatment of cartilage disorders and the regenerative engineering of cartilaginous tissue.

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Clinical Outcomes of Mesenchymal Stem Cell Injection With Arthroscopic Treatment in Older Patients With Osteochondral Lesions of the Talus

Cited by 89 publications

References 70 publications

Cartilage repair in the degenerative ageing knee

Cartilage repair in the degenerative ageing knee

Diagnosis and treatment of osteochondral lesions of the ankle: current concepts

Regenerative Engineering of Cartilage Using Adipose-Derived Stem Cells

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