Clinical outcomes in patients with isolated serous tubal intraepithelial carcinoma (STIC): A comprehensive review

Incidence and Characteristics of Unsuspected Neoplasia Discovered in High-Risk Women Undergoing Risk Reductive Bilateral Salpingooophorectomy

“…33 The incidence of STIC in these patients has been reported to range between 0.6% and 7%. 34 The frequency of detecting STIC in these women has increased since the introduction of the 'Sectioning and Extensively Examining the Fimbriated End' (SEE FIM) protocol for histopathological analysis of the fallopian tubes. 35,36 The SEE FIM protocol, which developed at Brigham and Women's Hospital, entails fixation of the entire tube and longitudinal sectioning of the distal 2 cm of the fimbriated end of the fallopian into 4 pieces followed by serial sectioning every 2 to 3 mm of the entire length.…”

A Case of Serous Tubal Intraepithelial Carcinoma Diagnosed by Cytology during the Operation

“…has been reported to occur in 0.6% to 7% women with BRCA1/2 mutations who receiving the prophylactic bilateral salpingo-oophorectomies [11] [12]. In our case, her past and family history related with breast or ovarian cancer could not be found, and the patient did not wish to examine the BRCA mutations.…”

“…Approximate 11.7% -15.3% of women with ovarian cancer have a family history of cancer, of which the majority has an inherited mutation in breast cancer susceptibility gene (BRCA) 1 or 2 [9] [10]. The incidence of STIC has been reported to range from 0.6% to 7% in BRCA mutations carriers [11] [12]. The tubal cytology is reported to be useful for ovarian cancer screening and detection [13].…”

Serous tubal intraepithelial carcinomas associated with high‐grade serous ovarian carcinomas: a systematic review

“…However, this checklist was developed for cohort, case‐control and cross‐sectional studies, and therefore was not consulted for all of the included studies. This review did not include studies investigating STICs identified in the high‐risk population after RRSO as this has already been systematically reviewed . We did not evaluate studies that only investigated serous carcinomas of a tubal or peritoneal origin.…”

“…It is, therefore, important to systematically review the quality of evidence that supports the notion that the FT may act as a source of HGSOC. While systematic reviews of studies that reported the frequency of STICs in patients undergoing RRSO have been conducted, no such review exists for studies linking STICs to established HGSOCs. Therefore, we have systematically reviewed published studies to estimate the rate of HGSOC that is associated with STICs.…”