Clinical Outcomes in 55 Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Who Were Asymptomatic at Hospital Admission in Shenzhen, China

Wang, Yanrong; Liu, Yingxia; Liu, Lei; Wang, Xianfeng; Luo, Nijuan; Li, Ling

doi:10.1093/infdis/jiaa119

Cited by 291 publications

(268 citation statements)

References 8 publications

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“…Finally, as a limited number of pediatric patients have been diagnosed in Shenzhen thus far, we have only included adult patients in this study. Effects of obesity on coronavirus infection or disease progression in children are yet to be reported (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16).…”

Section: Resultsmentioning

confidence: 99%

“…All patients with COVID-19 were carefully treated, and their data were collected by nurses, physicians, or other medical staff at the hospital. There was no missing information for all variables of interest in this study (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). We declare that no data related to obesity and COVID-19 severity from patients in our hospital have been published, submitted, or are in press.…”

Section: Study Design and Participant Criteriamentioning

confidence: 99%

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Obesity and COVID-19 Severity in a Designated Hospital in Shenzhen, China

et al. 2020

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OBJECTIVE Patients with obesity are at increased risk of exacerbations from viral respiratory infections. However, the association of obesity with the severity of coronavirus disease 2019 (COVID-19) is unclear. We examined this association using data from the only referral hospital in Shenzhen, China. RESEARCH DESIGN AND METHODS A total of 383 consecutively hospitalized patients with COVID-19 admitted from 11 January 2020 to 16 February 2020 and followed until 26 March 2020 at the Third People’s Hospital of Shenzhen were included. Underweight was defined as a BMI <18.5 kg/m2, normal weight as 18.5–23.9 kg/m2, overweight as 24.0–27.9 kg/m2, and obesity as ≥28 kg/m2. RESULTS Of the 383 patients, 53.1% were normal weight, 4.2% were underweight, 32.0% were overweight, and 10.7% were obese at admission. Obese patients tended to have symptoms of cough (P = 0.03) and fever (P = 0.06) compared with patients who were not obese. Compared with normal weight patients, those who were overweight had 1.84-fold odds of developing severe COVID-19 (odds ratio [OR] 1.84, 95% CI 0.99–3.43, P = 0.05), while those who were obese were at 3.40-fold odds of developing severe disease (OR 3.40, 95% CI 1.40–2.86, P = 0.007), after adjusting for age, sex, epidemiological characteristics, days from disease onset to hospitalization, presence of hypertension, diabetes, cardiovascular disease, chronic obstructive pulmonary disease, liver disease, and cancer, and drug used for treatment. Additionally, after similar adjustment, men who were obese versus those who were normal weight were at increased odds of developing severe COVID-19 (OR 5.66, 95% CI 1.80–17.75, P = 0.003). CONCLUSIONS In this study, obese patients had increased odds of progressing to severe COVID-19. As the severe acute respiratory syndrome coronavirus 2 may continue to spread worldwide, clinicians should pay close attention to obese patients, who should be carefully managed with prompt and aggressive treatment.

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Section: Resultsmentioning

confidence: 99%

Section: Study Design and Participant Criteriamentioning

confidence: 99%

Obesity and COVID-19 Severity in a Designated Hospital in Shenzhen, China

et al. 2020

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“…However, patients suffering from COVID-19 may also present with symptoms of upper respiratory tract infection, such as a sore throat (5-14%) and/or rhinorrhea (4%) [7,8]. Carriers of COVID-19 may shed a heavy viral load into the environment even if they are asymptomatic or present with very subtle symptoms [9,10]. Recently, anosmia, hyposmia and dysgeusia, which affect patients' senses of smell and taste, were identified as symptoms of COVID-19, with high prevalence in Europe, Korea and China [11].…”

Section: Introductionmentioning

confidence: 99%

Pearls of experience for safe and efficient hospital practices in otorhinolaryngology—head and neck surgery in Hong Kong during the 2019 novel coronavirus disease (COVID-19) pandemic

Cho

Yeung

et al. 2020

J of Otolaryngol - Head & Neck Surg

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The 2019 novel coronavirus disease (COVID-19) epidemic originated in Wuhan, China and spread rapidly worldwide, leading the World Health Organization to declare an official global COVID-19 pandemic in March 2020. In Hong Kong, clinicians and other healthcare personnel collaborated closely to combat the outbreak of COVID-19 and minimize the cross-transmission of disease among hospital staff members. In the field of otorhinolaryngologyhead and neck surgery (OHNS) and its various subspecialties, contingency plans were required for patient bookings in outpatient clinics, surgeries in operating rooms, protocols in wards and other services. Infected patients may shed severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) particles into their environments via body secretions. Therefore, otolaryngologists and other healthcare personnel in this specialty face a high risk of contracting COVID-19 and must remain vigilant when performing examinations and procedures involving the nose and throat. In this article, we share our experiences of the planning and logistics undertaken to provide safe and efficient OHNS practices over the last 2 months, during the COVID-19 pandemic. We hope that our experiences will serve as pearls for otolaryngologists and other healthcare personnel working in institutes that serve large numbers of patients every day, particularly with regard to the sharing of clinical and administrative tasks during the COVID-19 pandemic.

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“…Since that time, the COVID-19 outbreak has rapidly spread throughout the world and has been declared a public health emergency of international concern by the World Health Organization. [1][2][3] Currently, more than 1,400,000 cases of COVID-19 have been documented globally with more than 80,000 deaths. 4 The majority of deaths are associated with acute respiratory distress syndrome, severe pneumonia, and subsequent shock and organ failure.…”

Section: Introductionmentioning

confidence: 99%

“…3 Asymptomatic patients have also tested positive for COVID-19, although the exact number of asymptomatic carriers is unknown due to the lack of testing and the prolonged incubation period. 2,3,5 SARS-CoV-2 remains viable in aerosols for at least 3 hours, 6,7 leading to the recommendation by the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) to avoid aerosol-generating procedures (AGPs), such as tracheotomy, in patients with COVID-19 when pos-sible. 8 Furthermore, delaying or avoiding tracheotomy reduces the risk of viral transmission to health-care providers and conserves necessary personal protective equipment (PPE).…”

Section: Introductionmentioning

confidence: 99%

Surgical Considerations for an Awake Tracheotomy During the COVID-19 Pandemic

Crossley

Clark

Brody³

et al. 2020

Journal of Laparoendoscopic & Advanced Surgical Techniques

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Background: The current global COVID-19 pandemic is caused by the novel coronavirus Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2). Given that SARS-CoV-2 is highly transmissible, surgical societies have recommended that procedures with a high risk of aerosolization be avoided or delayed. However, some high-risk procedures, such as those related to head and neck malignancies, cannot always be delayed. Care must be taken during aerosol-generating procedures to minimize viral transmission as much as possible. Preoperative testing for COVID-19, limited operating room personnel, adequate personal protective equipment, and surgical technique are factors to consider for high-risk procedures. Methods: This article presents the case of an awake tracheotomy performed for a transglottic mass causing airway obstruction. Results: With detailed planning and specific techniques, the amount of aerosolization was reduced, and the procedure was performed as safely as possible. Conclusion: This case provides a template for future aerosol-generating procedures during respiratory pandemics.

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Clinical Outcomes in 55 Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Who Were Asymptomatic at Hospital Admission in Shenzhen, China

Cited by 291 publications

References 8 publications

Obesity and COVID-19 Severity in a Designated Hospital in Shenzhen, China

Obesity and COVID-19 Severity in a Designated Hospital in Shenzhen, China

Pearls of experience for safe and efficient hospital practices in otorhinolaryngology—head and neck surgery in Hong Kong during the 2019 novel coronavirus disease (COVID-19) pandemic

Surgical Considerations for an Awake Tracheotomy During the COVID-19 Pandemic

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