Clinical outcomes following treatment of human intrabony defects with GTR/bone replacement material or access flap alone

Abstract

The results of this trial indicated that regenerative periodontal surgery with a GTR/bone replacement material offers an additional benefit in terms of CAL gains, PPD reductions and predictability of outcomes with respect to papilla preservation flaps alone.

Treatment of intrabony defects with guided tissue regeneration in aggressive periodontitis: clinical outcomes at 6 and 12 months

“…The average FMPS in the present study were low from the beginning since all patients had received non-surgical therapy with a session of oral hygiene instruction and reinforcement as necessary. This FMPS remained relatively low throughout the follow-up period but still relatively higher than other GTR studies [20,45]. Such differences may partly contribute to the reduced clinical improvements in terms of ΔCAL and ΔPPD of the present study when compared to other investigations [20,45].…”

A phase IIa randomized controlled pilot study evaluating the safety and clinical outcomes following the use of rhGDF-5/β-TCP in regenerative periodontal therapy

“…On the other hand, the magnitude of clinical improvements appeared to be in the range of those obtained with other regenerative materials such as a recombinant plateletderived growth factor (rhPDGF BB) on a β-TCP carrier, an enamel matrix protein derivative alone or guided tissue regeneration either alone or combined with grafting materials [20][21][22][23][24][25][26][27]. Furthermore, it is also important to note that the results observed in the control group compare favorably with previous studies evaluating treatment of intrabony defects using flap surgery alone indicating that substantial clinical improvements may be achieved with this treatment modality if an optimal level of plaque control is maintained [21][22][23][26][27][28].…”

Interdisciplinary Collaboration Between Orthodontics and Periodontics

“…In this way, the connective tissue of the flap is kept at a distance from the healing sites and the progenitor cells of the periodontal ligament can repopulate the root surface leading to a newly formed periodontium (Gottlow et al 1984;Caton et al 1987). Regenerative surgical therapy is used to obtain an increase in the reduced support apparatus and the results are predictable in the correction of angular defects (Murphy and Gunsolley 2003;Tonetti et al 2004;Cortellini and Tonetti 2005;Needleman et al 2005). Presently there are several known regenerative approaches, among them the use of resorbable and non-resorbable membranes, barrier effect, bone grafts and induced periodontal regeneration with enamel matrix derivate (Esposito et al 2003).…”