Clinical Outcomes and Patterns of Failure in Pineoblastoma: A 30-Year, Single-Institution Retrospective Review

Farnia, Benjamin; Allen, Pamela K.; Brown, Paul D.; Khatua, Soumen; Levine, Nicholas B.; Li, Jing; Penas‐Prado, Marta; Mahajan, Anita; Ghia, Amol J.

doi:10.1016/j.wneu.2014.07.010

Cited by 45 publications

(27 citation statements)

References 40 publications

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“…Our patients, on average, had a 109-month progression-free survival among the 8 patients with clinical follow-up who did not die of their Gener,10 initial disease. In addition, after recurrence, our patients still lived, on average, 36 months from the time of recurrence.…”

Section: Discussionmentioning

confidence: 76%

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Clinical, Pathological, and Surgical Outcomes for Adult Pineoblastomas

et al. 2015

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Section: Discussionmentioning

confidence: 76%

“…In our review of the literature, 4 series showed a predominance of males (7,10,17,21) and 2 studies showed a slight predominance of females (11,30). Because of the rarity of these tumors, it is unlikely that we can predict if these tumors in adults are reliably associated with gender predominance.…”

Section: Discussionmentioning

confidence: 89%

Clinical, Pathological, and Surgical Outcomes for Adult Pineoblastomas

et al. 2015

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“…Pineoblastomas are a rare malignant tumor, with an estimated incidence of <0.1% of all intracranial tumors, making the development of treatment consensus difficult (10). The lesions are more common in children and adolescents than in adults, with an average age at diagnosis of 13 years.…”

Section: Discussionmentioning

confidence: 99%

“…Operation is the first choice of treatment, and maximal safe surgical resection is expected, although technically difficult due to the deep location of the pineal gland. Adjuvant radiotherapy with CSI and a local boost are usually given, and often combined with systemic chemotherapy to control or prevent distant metastasis (10). The current consensus of medulloblastoma grouping has moved from histologically to genetically defined subgroups as a result of better understanding of medulloblastoma biology (12).…”

Section: Discussionmentioning

confidence: 99%

“…A study the summarized the existing literature of 299 pineoblastoma patients reported a 5-year survival rate of 15% for children younger than 5 years old, compared to 57% for children older than 5 years (14). Another study of 31 patients with pineoblastomas with a median age of 18.2 years showed a 5-year survival of 62.6% (10). A study that analyzed the data of 12 European centers reported a 5-year survival rate of 10% among 29 pineoblastoma patients with a median age of 12.5 years, and the median overall survival ranged from 1.3 to 2.1 years (15).…”

Section: Discussionmentioning

confidence: 99%

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Treatment outcomes for pediatric pineoblastoma: a single institute experience in Taiwan

Kang¹,

Lin²,

Lee³

et al. 2018

Ther Radiol Oncol

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Background: Our purpose was to evaluate the clinical outcomes of pediatric pineoblastoma patients after multimodality treatment. Methods: The medical records of 11 children with pineoblastomas treated at Taipei Veterans General Hospital between 1991 and 2006 were retrospectively reviewed. There were 7 females (63.6%) and 4 males (36.4%) with a median age at diagnosis of 5.25 years (range, 1.47-16.8 years). Age, sex, symptoms, pathological findings, treatment modalities, failure patterns, recurrence date, death date, and toxicities were recorded. Survival curves were estimated with the Kaplan-Meier method, and univariate Cox proportional hazards models were used to identify possible risk factors. Results: The median overall survival was 2.3 years, with 2-and 5-year survival rates of 63.6% and 36.4%, respectively. Eight patients (72.7%) died after serial treatments, and extensive seeding with multi-organ failure was the most common failure pattern. Three patients (27.2%) were alive without disease recurrence. Kaplan-Meier survival curves showed a significant difference (P<0.05) when compared by age at diagnosis (over or under 3 years old) (P=0.0014). Two out of the three long-term survivors received stereotactic biopsy, craniospinal irradiation (CSI) with focal boost, and chemotherapy without radical surgery. Conclusions: Our results showed survival was associated with age at diagnosis. Long-term survival can be achieved for patients who receive radiotherapy plus chemotherapy. Further studies are needed to determine the best treatment options for pediatric pineoblastoma patients.

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