Clinical outcome 10 years after infant heart transplantation

Chinnock, Richard; Cutler, Drew; Baum, Marti

doi:10.1016/s1058-9813(00)00047-3

Cited by 15 publications

(12 citation statements)

References 10 publications

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“…This aligns with findings by Chinnock et al who reported good renal function in 29 infant heart recipients greater than 10 years posttransplant (13). Similar to other reports, somatic growth was normal with height and weight generally being in the low end of normal range in most patients (7,13).…”

Section: Posttransplant Outcomessupporting

confidence: 91%

“…In addition, infants transplanted at <30 days of life have been shown to have a survival advantage at 10 years of up to 15% over children transplanted at any later age (9). While long-term survival and clinical outcomes are encouraging (6,13), infants face a scarcity of donor organs and long wait-times. Reports in the literature of wait-list mortality for infants range from 25 to 50%.…”

Section: Introductionmentioning

confidence: 99%

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Waiting Before Birth: Outcomes After Fetal Listing for Heart Transplantation

Pollock-BarZiv

McCrindle

West

et al. 2008

American Journal of Transplantation

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Following fetal diagnosis of a profound heart defect, transplantation (HTx) is an alternative to pregnancy termination or neonatal surgical palliation. Retrospective review of the cardiac and transplant databases of fetal listings for HTx between 1990 and July 2006 was undertaken to describe outcomes after listing. We identified 26 fetal listings (of 269 total listings). Diagnoses included congenital heart disease (n = 24) and cardiomyopathy (n = 2). Seven patients were delisted after birth: in five cases parents opted for surgical palliation, two clinically improved. One patient died waitlisted (stillborn). Time wait-listed as a fetus ranged from 1-41 days (median 19 days). Eighteen patients underwent HTx (median weight 2.8 kg, range 2.1-10.9 kg); median days wait-listed after birth was 22 (4 h-123 days). Two fetuses were surgically delivered at 36 weeks gestation when a donor organ became available; 11 were transplanted as neonates (<30 days). The median age at HTx was 1 month (4 h-2.6 months). Fetal listing for HTx increases the potential window of opportunity for a donor organ to become available; patients had low wait-list mortality and a fair intermediate-term outcome. Well-defined criteria for eligibility for fetal listing and priority allocation to infants over fetuses seem rational approaches for centers that offer fetal listing.

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Section: Posttransplant Outcomessupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Waiting Before Birth: Outcomes After Fetal Listing for Heart Transplantation

Pollock-BarZiv

McCrindle

West

et al. 2008

American Journal of Transplantation

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“…146,147 Pediatric transplant recipients have generally exhibited normal growth rates after transplantation, but their absolute heights and weights tend to be in the lower range of normal. 148,149 However, some children will continue to demonstrate a decrement in skeletal maturation after transplantation. 146 Although these studies have demonstrated normal rates of increase in height and weight after transplantation, they do not demonstrate evidence of acceleration of these rates after transplantation.…”

Section: Canter Et Almentioning

confidence: 99%

Indications for Heart Transplantation in Pediatric Heart Disease

Canter¹,

Shaddy²,

Bernstein³

et al. 2007

Circulation

258

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Background— Since the initial utilization of heart transplantation as therapy for end-stage pediatric heart disease, improvements have occurred in outcomes with heart transplantation and surgical therapies for congenital heart disease along with the application of medical therapies to pediatric heart failure that have improved outcomes in adults. These events justify a reevaluation of the indications for heart transplantation in congenital heart disease and other causes of pediatric heart failure. Methods and Results— A working group was commissioned to review accumulated experience with pediatric heart transplantation and its use in patients with unrepaired and/or previously repaired or palliated congenital heart disease (children and adults), in patients with pediatric cardiomyopathies, and in pediatric patients with prior heart transplantation. Evidence-based guidelines for the indications for heart transplantation or retransplantation for these conditions were developed. Conclusions— This evaluation has led to the development and refinement of indications for heart transplantation for patients with congenital heart disease and pediatric cardiomyopathies in addition to indications for pediatric heart retransplantation.

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“…At 10 years or more post-transplant, 19 of 29 parents (66%) of infant transplant survivors described their child as being developmentally normal. 4 Although the majority of patients have shown developmental outcomes in the normal range, those studies suggest that infants who undergo heart transplantation are at increased risk for impaired neuropsychologic functioning.…”

mentioning

confidence: 99%