Clinical, microbiologic, and epidemiologic characteristics of Pseudomonas aeruginosa infections in a University Hospital, Malatya, Turkey

Yetkin, Gülay; Otlu, Barış; Çiçek, Ayşegül Çopur; Kuzucu, Çiğdem; Durmaz, Rıza

doi:10.1016/j.ajic.2005.11.010

Cited by 69 publications

(62 citation statements)

References 22 publications

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“…The resistance pattern of P. aeruginosa to quinolones observed in the present study was similar to other results reported [21,24]. We noticed that, among cephalosporin, a high resistance rate was exhibited against cefepime and cefotriaxone, which was consistent with other reports [20,21,30]. In contrast, earlier studies have reported cefepime to be the most effective antimicrobial agent against P. aeruginosa [31,[32][33].…”

Section: Discussioncontrasting

confidence: 52%

QacE and QacE?1 Genes and Their Correlation to Antibiotics and Biocides Resistance Pseudomonas aeruginosa

Helal¹,

Khan²

2015

Am. J. Biomed. Sci.

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One of the serious and growing challenges for infection control programs worldwide is hospital acquired infections. Pseudomonas aeruginosa is considered the most common cause of hospital acquired Gramnegative infections. Intensive exposure of hospital pathogens to biocides may result in the emergence of resistance not only to the biocides, but possibly to antibiotics as well. Thus, the current study was done to investigate the prevalence of qacE∆1 and qacE genes and their correlation to antibiotics and biocides resistance in Pseudomonas aeruginosa isolated in Egypt. The antimicrobial activity of six biocides against drug sensitive and multi-drug resistant Pseudomonas aeruginosa was evaluated. Phenol and formalin displayed a higher antimicrobial activity compared to other biocides tested. Minimum inhibitory concentration (MIC) values of chlorine releasing agents were higher than the dilution prescribed by their manufactures. The qacE∆1 gene was identified in 57.8% of multidrug resistant isolates and 21.4% in susceptible strains, While, qacE gene was only detected among multi-drug resistant Pseudomonas aeruginosa. This study reported a correlation between qacE∆1 and multidrug resistance Pseudomonas aeruginosa, while there was no correlation between the presence of qac genes and increased MIC values to biocides. The effectiveness of biocides is very important to control microbial population and prevent the transmission of infections in hospitals. In conclusion we highlight the need for health care facilities to assess the antimicrobial effectiveness of biocides periodically.

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Section: Discussioncontrasting

confidence: 52%

QacE and QacE?1 Genes and Their Correlation to Antibiotics and Biocides Resistance Pseudomonas aeruginosa

Helal¹,

Khan²

2015

Am. J. Biomed. Sci.

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“…A recent study performed on carbepenemresistant K. pneumoniae clinical isolates in Shandog, China, showed that the strains in the same PFGE type were isolated in the same clinic for more than 2 years (6). As already indicated (18,42), the high rate of clonally relatedness among the isolates from different services in a wide time period was an important evidence for ongoing cross-transmission of these resistant isolates in the current study setting. Infected or colonized patients, hospital staff, and/or contaminated equipment might affect this cross-transmission.…”

Section: Discussionmentioning

confidence: 71%

Molecular Characterization of Carbapenem-Resistant Klebsiella pneumoniae Species Isolated From a Tertiary Hospital, Ankara, Turkey

Çelikbilek¹,

Ünaldı²,

Kırca³

et al. 2017

Jundishapur J Microbiol

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Background: Carbapenem-resistant Klebsiella pneumoniae isolates can spread among the hospitalized patients and result in serious infections and increase mortality. Molecular studies provide useful information about resistance mechanisms and crosstransmission among the resistant isolates. Objectives: The current study aimed at investigating phenotypic and molecular characteristics of the carbapenem resistance and clonal relationship among the K. pneumoniae isolates recovered from infection sites and rectal swabs of the patients hospitalized in a tertiary hospital. Methods: Resistance to carbapenems was investigated by disc-diffusion and E-test methods. Modified Hodge test (MHT) and ethylenediaminetetraacetic acid (EDTA)-combine disc (ECD) methods were performed to determine carbapenemases. Carbapenemase-encoding genes including blaOXA-48, blaNDM-1, blaKPC, blaIMP, and blaVIM were investigated by multiplex polymerase chain reaction (PCR). Clonal relationship among the isolates was determined by the pulsed-field gel electrophoresis (PFGE). Results: Carbapenem resistance was observed in 93 (5.8%) of the 1605 K. pneumoniae isolates. Majority (n = 66, 71%) of the resistant isolates were recovered from the patients in intensive care units (ICUs). Almost all carbapenem-resistant K. pneumoniae isolates (n = 91, 97.8%) were positive with MHT. Only 6 (6.5%) of the resistant isolates were positive with ECD method. The blaOXA-48 and blaNDM-1 were found in 90.3% (n = 84) and 6.5% (n = 6) of the resistant isolates, respectively. The pulsed-field gel electrophoresis yielded

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“…PFGE, randomly amplified polymorphic DNA analysis, and ribotyping have been used to evaluate circulation of P. aeruginosa in clinical areas [22,23]. The first two are better able to discriminate genotypic heterogeneity.…”

Section: Discussionmentioning

confidence: 99%

Identifying and controlling a multiresistant pseudomonas aeruginosa outbreak in a latin-american cancer centre and its associated risk factors

Cortés¹,

Cuervo²,

Urdaneta³

et al. 2009

Braz J Infect Dis

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Pseudomonas aeruginosa is an important and frightening microorganism for patients suffering from cancer. Multiresistant P. aeruginosa (MRPA) may appear as a consequence of exposure to multiple antibiotics or from a breakdown in infection control practices. This article reports an MRPA outbreak in a cancer treatment centre and the consequent case control study. Mechanical ventilation was identified as being the main risk factor for developing MRPA colonisation or infection; molecular analysis confirmed the outbreak. A multifaceted strategy was adopted, involving reinforcing hand-washing practices, contact isolation, antibiotic restriction and suction devices for mechanically-ventilated patients. MRPA was controlled and the outbreak ended. Such strategy may be effective in controlling MRPS in low-resource environments amongst high risk cancer patients.

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Clinical, microbiologic, and epidemiologic characteristics of Pseudomonas aeruginosa infections in a University Hospital, Malatya, Turkey

Cited by 69 publications

References 22 publications

QacE and QacE?1 Genes and Their Correlation to Antibiotics and Biocides Resistance Pseudomonas aeruginosa

QacE and QacE?1 Genes and Their Correlation to Antibiotics and Biocides Resistance Pseudomonas aeruginosa

Molecular Characterization of Carbapenem-Resistant Klebsiella pneumoniae Species Isolated From a Tertiary Hospital, Ankara, Turkey

Identifying and controlling a multiresistant pseudomonas aeruginosa outbreak in a latin-american cancer centre and its associated risk factors

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