Clinical/Metabolic Correlations in Multiple System Atrophy

Status and trends in the development of clinical diagnostic agents

“…18 F‐FDG has been also approved for myocardial perfusion imaging, as listed on the label (Label Reference ID: 3073389). It is also able to cross the blood–brain barrier (BBB) and allows the visualization of brain metabolism, e.g., associated with abnormal activity patterns found in patients with obsessive‐compulsive disorder, epilepsy, or multiple system atrophy . In addition to 18 F‐FDG, there are other tracers based on 18 F as well.…”

“…It is also able to cross the blood-brain barrier (BBB) and allows the visualization of brain metabolism, e.g., associated with abnormal activity patterns found in patients with obsessive-compulsive disorder, epilepsy, or multiple system atrophy. [38][39][40] In addition to 18 F-FDG, there are other tracers based on 18 F as well. In this context, tracers specifically detecting β-amyloid plaques were developed and approved for the diagnosis of Alzheimer's disease (see Table 4), and the tracer 18 F-fluciclovine has been approved for the detection of primary prostate cancer (EMA application was filed in 2016 46 ).…”

Status and trends in the development of clinical diagnostic agents

“…18 F‐FDG has been also approved for myocardial perfusion imaging, as listed on the label (Label Reference ID: 3073389). It is also able to cross the blood–brain barrier (BBB) and allows the visualization of brain metabolism, e.g., associated with abnormal activity patterns found in patients with obsessive‐compulsive disorder, epilepsy, or multiple system atrophy . In addition to 18 F‐FDG, there are other tracers based on 18 F as well.…”

“…It is also able to cross the blood-brain barrier (BBB) and allows the visualization of brain metabolism, e.g., associated with abnormal activity patterns found in patients with obsessive-compulsive disorder, epilepsy, or multiple system atrophy. [38][39][40] In addition to 18 F-FDG, there are other tracers based on 18 F as well. In this context, tracers specifically detecting β-amyloid plaques were developed and approved for the diagnosis of Alzheimer's disease (see Table 4), and the tracer 18 F-fluciclovine has been approved for the detection of primary prostate cancer (EMA application was filed in 2016 46 ).…”

The mechanism of impaired delayed recall verbal memory function in Parkinson's disease with orthostatic hypotension: a multiple imaging study

“…Meanwhile, there are some studies which indicated that PD patients with OH had a more severe impairment on tests of verbal immediate and delayed memory, and there were higher white matter lesion scores recorded by brain magnetic resonance imaging (MRI) in the OH group, which supported the vascular hypothesis ( 14 , 18 ). Compared with dCA and MRI, 18fluorine-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) provides more information on the underlying pathophysiology by highlighting the metabolic dysfunction of specific anatomical structures which can then be correlated with cognitive impairment ( 19 ). However, there are limited studies on the relationship between the cognitive impairment and PD with or without OH patients as shown by brain 18F-FDG PET patterns.…”

Preclinical Impairment of the Striatal Dopamine Transporter System in Sporadic Olivopontocerebellar Atrophy: Studied with [¹²³I]β-CIT and SPECT

“…A positron emission tomographic (PET) study with [ 18 F]fluorodeoxyglucose showed decreased metabolism in the putamen, caudate nuclei and thalamus as well as the cerebellum in patients with sOPCA and MSA [13]. Antonini et al [14]reported that PET with the tracers [ 18 F]fluorodeoxyglucose and [ 11 C]raclopride were sensitive and effective measures of striatal function and may help to characterize patients with MSA.…”

Status and trends in the development of clinical diagnostic agents

“…18 F‐FDG has been also approved for myocardial perfusion imaging, as listed on the label (Label Reference ID: 3073389). It is also able to cross the blood–brain barrier (BBB) and allows the visualization of brain metabolism, e.g., associated with abnormal activity patterns found in patients with obsessive‐compulsive disorder, epilepsy, or multiple system atrophy . In addition to 18 F‐FDG, there are other tracers based on 18 F as well.…”

“…It is also able to cross the blood-brain barrier (BBB) and allows the visualization of brain metabolism, e.g., associated with abnormal activity patterns found in patients with obsessive-compulsive disorder, epilepsy, or multiple system atrophy. [38][39][40] In addition to 18 F-FDG, there are other tracers based on 18 F as well. In this context, tracers specifically detecting β-amyloid plaques were developed and approved for the diagnosis of Alzheimer's disease (see Table 4), and the tracer 18 F-fluciclovine has been approved for the detection of primary prostate cancer (EMA application was filed in 2016 46 ).…”

The mechanism of impaired delayed recall verbal memory function in Parkinson's disease with orthostatic hypotension: a multiple imaging study

“…Meanwhile, there are some studies which indicated that PD patients with OH had a more severe impairment on tests of verbal immediate and delayed memory, and there were higher white matter lesion scores recorded by brain magnetic resonance imaging (MRI) in the OH group, which supported the vascular hypothesis ( 14 , 18 ). Compared with dCA and MRI, 18fluorine-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) provides more information on the underlying pathophysiology by highlighting the metabolic dysfunction of specific anatomical structures which can then be correlated with cognitive impairment ( 19 ). However, there are limited studies on the relationship between the cognitive impairment and PD with or without OH patients as shown by brain 18F-FDG PET patterns.…”

Preclinical Impairment of the Striatal Dopamine Transporter System in Sporadic Olivopontocerebellar Atrophy: Studied with [¹²³I]β-CIT and SPECT

“…A positron emission tomographic (PET) study with [ 18 F]fluorodeoxyglucose showed decreased metabolism in the putamen, caudate nuclei and thalamus as well as the cerebellum in patients with sOPCA and MSA [13]. Antonini et al [14]reported that PET with the tracers [ 18 F]fluorodeoxyglucose and [ 11 C]raclopride were sensitive and effective measures of striatal function and may help to characterize patients with MSA.…”

Status and trends in the development of clinical diagnostic agents

“…18 F‐FDG has been also approved for myocardial perfusion imaging, as listed on the label (Label Reference ID: 3073389). It is also able to cross the blood–brain barrier (BBB) and allows the visualization of brain metabolism, e.g., associated with abnormal activity patterns found in patients with obsessive‐compulsive disorder, epilepsy, or multiple system atrophy . In addition to 18 F‐FDG, there are other tracers based on 18 F as well.…”

“…It is also able to cross the blood-brain barrier (BBB) and allows the visualization of brain metabolism, e.g., associated with abnormal activity patterns found in patients with obsessive-compulsive disorder, epilepsy, or multiple system atrophy. [38][39][40] In addition to 18 F-FDG, there are other tracers based on 18 F as well. In this context, tracers specifically detecting β-amyloid plaques were developed and approved for the diagnosis of Alzheimer's disease (see Table 4), and the tracer 18 F-fluciclovine has been approved for the detection of primary prostate cancer (EMA application was filed in 2016 46 ).…”

The mechanism of impaired delayed recall verbal memory function in Parkinson's disease with orthostatic hypotension: a multiple imaging study

“…Meanwhile, there are some studies which indicated that PD patients with OH had a more severe impairment on tests of verbal immediate and delayed memory, and there were higher white matter lesion scores recorded by brain magnetic resonance imaging (MRI) in the OH group, which supported the vascular hypothesis ( 14 , 18 ). Compared with dCA and MRI, 18fluorine-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) provides more information on the underlying pathophysiology by highlighting the metabolic dysfunction of specific anatomical structures which can then be correlated with cognitive impairment ( 19 ). However, there are limited studies on the relationship between the cognitive impairment and PD with or without OH patients as shown by brain 18F-FDG PET patterns.…”

Preclinical Impairment of the Striatal Dopamine Transporter System in Sporadic Olivopontocerebellar Atrophy: Studied with [¹²³I]β-CIT and SPECT

“…A positron emission tomographic (PET) study with [ 18 F]fluorodeoxyglucose showed decreased metabolism in the putamen, caudate nuclei and thalamus as well as the cerebellum in patients with sOPCA and MSA [13]. Antonini et al [14]reported that PET with the tracers [ 18 F]fluorodeoxyglucose and [ 11 C]raclopride were sensitive and effective measures of striatal function and may help to characterize patients with MSA.…”