Clinical Investigation of Off-Flap Epi-LASIK for Moderate to High Myopia

Wang, Qinmei; Fu, Aicun; Yu, Yang; Xu, Chenchen; Xiao-xing, Wang; Chen, Shihao; Yu, A-Yong

doi:10.1167/iovs.07-0827

Cited by 25 publications

(47 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The authors did not find any significant difference in postoperative pain intensity between the two groups. The study by Wang et al 13 and our study both indicate the lack of any significant benefit of retaining the epithelial flap after Epi-LASIK.…”

Section: Discussioncontrasting

confidence: 49%

Comparative evaluation of ‘flap on’ and ‘flap off’ techniques of Epi-LASIK in low-to-moderate myopia

Sharma

Kaushal

Jhanji

et al. 2008

Eye

View full text Add to dashboard Cite

Section: Discussioncontrasting

confidence: 49%

Comparative evaluation of ‘flap on’ and ‘flap off’ techniques of Epi-LASIK in low-to-moderate myopia

Sharma

Kaushal

Jhanji

et al. 2008

Eye

View full text Add to dashboard Cite

“…The most important initial event after surface ablation is re-epithelialization because the outcome of surface ablation is closely related to epithelial wound healing response [3,19]. Katsanevaki et al [21] and Dai et al [22] reported mean times to epithelial healing after epi-LASIK surgery of 4.7 ± 0.87 and 3.80 ± 0.59 days, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…Wang et al [19] reported that off-flap epi-LASIK offers comparable postoperative pain, a lower level of corneal haze, faster visual recovery, and better visual quality in comparison with on-flap epi-LASIK. Kalyvianaki et al [20] reported that epi-LASIK and off-flap epi-LASIK had equal visual and refractive results for the treatment of low and moderate myopia.…”

Section: Introductionmentioning

confidence: 99%

Effect of Flap Removal in Myopic Epi-LASIK Surgery on Visual Rehabilitation and Postoperative Pain: A Prospective Intraindividual Study

Lee

Park

et al. 2010

Ophthalmologica

View full text Add to dashboard Cite

Purpose: A prospective intraindividual study to evaluate the effect of flap removal in myopic epi-LASIK surgery on visual rehabilitation and postoperative pain. Methods: Ninety eyes of 45 patients were treated for myopia with epi-LASIK. In each patient, the epithelial flap was repositioned in one eye after epi-LASIK (group 1) while the flap was removed in the other (group 2). Uncorrected visual acuity (UCVA), best corrected visual acuity (BCVA), spherical equivalent (SE) refraction, postoperative pain and corneal haze were examined for 6 months after surgery in both groups. Results: Group 2 had a better UCVA at 4 days and BCVA at 1 week after surgery (p = 0.001, p = 0.043) than group 1. No significant differences were observed between the two groups in terms of UCVA, BCVA, or SE refraction at 1 week and 1, 2 and 6 months. Postoperative pain scores were similar for both groups. In group 2, severe pain (pain level ≧6) was relatively less than in group 1 at 2 h and 12 h after surgery. Corneal haze levels in both groups were not different. Conclusions: Epi-LASIK surgery with flap removal was found to significantly promote re-epithelialization and visual recovery during the early postoperative period. It was also found to be more predictable and less painful than epi-LASIK surgery.

show abstract

“…Six RCTs and 3 comparative studies published between 2008 and 2011 met the inclusion criteria [7,8,9,13,14,15,16,17,18]. A total of 489 patients (958 eyes) underwent off-flap epi-LASIK and on-flap epi-LASIK.…”

Section: Resultsmentioning

confidence: 99%

“…Recently, some prospective randomized controlled trials (RCTs) have shown that epi-LASIK without retained epithelial flaps (off-flap) had comparable or even better results in regard to postoperative pain, epithelial healing, or vision recovery [7,8,9]. However, the conclusion of a single RCT is limited by the small size, different population, follow-up period, and surgery technique.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Clinical Outcomes between ‘On-Flap’ and ‘Off-Flap’ Epi-LASIK for Myopia: A Meta-Analysis

Feng

Chen²,

Stojanović³

et al. 2011

Ophthalmologica

Self Cite

View full text Add to dashboard Cite

Objective: To examine possible differences in clinical outcomes between off-flap and on-flap epipolis laser in situ keratomileusis (epi-LASIK) for myopia. Methods: Pertinent studies were selected by extensive searches. A total of 9 studies reporting on a total of 958 eyes were included in the present meta-analysis. Statistical analysis was performed using RevMan 5.0 software. Results: There were no significant differences in the final refractive spherical equivalent (p = 0.38), manifest refractive spherical equivalent within ±0.50 D of the target (p = 0.76), final uncorrected visual acuity (p = 0.90), loss of ≧1 line of best spectacle-corrected visual acuity (p = 0.99), and corneal haze at 3 months postoperatively (p = 0.96) or more than 6 months (p = 0.64). More patients felt severe pain in the on-flap group than in the off-flap group, although this finding was not statistically significant (p = 0.05). However, off-flap epi-LASIK had a better mean uncorrected visual acuity at 3 days (p = 0.04) and 5 days (p = 0.01), and faster re-epithelialization (p < 0.00001) after surgery. Conclusions: According to the available data, off-flap and on-flap epi-LASIK had equal visual and refractive outcomes for the treatment of myopia. Off-flap epi-LASIK had more rapid re-epithelialization and visual recovery compared to on-flap epi-LASIK.

show abstract

Clinical Investigation of Off-Flap Epi-LASIK for Moderate to High Myopia

Abstract: In comparison with on-flap epi-LASIK, off-flap epi-LASIK offers comparable postoperative pain, a lower level of haze formation, a rapider visual recovery, and better visual quality. Further investigations of a larger number of subjects and longer follow-up periods are warranted.

Cited by 25 publications

References 18 publications

Comparative evaluation of ‘flap on’ and ‘flap off’ techniques of Epi-LASIK in low-to-moderate myopia

Comparative evaluation of ‘flap on’ and ‘flap off’ techniques of Epi-LASIK in low-to-moderate myopia

Effect of Flap Removal in Myopic Epi-LASIK Surgery on Visual Rehabilitation and Postoperative Pain: A Prospective Intraindividual Study

Comparison of Clinical Outcomes between ‘On-Flap’ and ‘Off-Flap’ Epi-LASIK for Myopia: A Meta-Analysis

Contact Info

Product

Resources

About