Clinical improvement following dermabrasion of photoaged skin correlates with synthesis of collagen I

Nelson, B. R.

doi:10.1001/archderm.130.9.1136

Cited by 22 publications

(11 citation statements)

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“…Wrinkle improvement in patients who have undergone resurfacing appears to increase between months 1 and 6, suggesting that fibroblast activity and collagen remodeling occur during this period to form a sustained band of fibrosis. Documenting increased collagen formation in resurfaced skin by in situ hybridization and Western blot analysis, similar to 12 weeks postdermabrasion results in which Nelson et al 18 showed a 3-fold increase in type I procollagen, would provide more evidence to support this proposed mechanism.…”

Section: Discussionsupporting

confidence: 58%

Comparative Clinical Trial of 2 Carbon Dioxide Resurfacing Lasers With Varying Pulse Durations

Duke¹,

Khatri²,

Grevelink³

et al. 1998

Arch Dermatol

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Section: Discussionsupporting

confidence: 58%

Comparative Clinical Trial of 2 Carbon Dioxide Resurfacing Lasers With Varying Pulse Durations

Duke¹,

Khatri²,

Grevelink³

et al. 1998

Arch Dermatol

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“…Several anti-oxidants are incorporated into topical skin care products, including vitamins C and E, co-enzyme Q10, ferulic acid, green tea, idebenone, pycnogenol and silymarin. Resurfacing procedures have been shown to sometimes spur the formation of new collagen with a normal staining pattern, as opposed to the basophilic elastotic masses of collagen characteristic of photo-aged skin [81]. It is possible that the potential of growth factors, cytokines and telomerase will eventually be harnessed via technological advancement and innovation in the burgeoning fields of tissue engineering and gene therapy [82].…”

Section: Treatmentmentioning

confidence: 99%

Skin ageing and its treatment

Baumann¹

2007

The Journal of Pathology

532

477

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The effects of chronic sun exposure on skin are readily apparent when skin not typically exposed to the sun and skin regularly exposed to the sun are compared. While the sun is not the only aetiological factor in the dynamic process of skin ageing, it is the primary exogenous cause among several internal and environmental elements. Thus, photo-ageing, the main focus of this article, is a subset of extrinsic skin ageing. The influence of the sun in extrinsic skin ageing, as well as its role in potentially altering the normal course of intrinsic (also known as natural or cellular) ageing, is discussed. Telomeres, the specialized structures found at the ends of chromosomes, are believed to be integral to cellular ageing as well as in the development of cancer. The ageing process, both intrinsic and extrinsic, is also believed to be influenced by the formation of free radicals, also known as reactive oxygen species. The loss of collagen is considered the characteristic histological finding in aged skin. Wrinkling and pigmentary changes are directly associated with photo-ageing and are considered its most salient cutaneous manifestations. Such photodamage represents the cutaneous signs of premature ageing. In addition, deleterious consequences of chronic sun exposure, specifically various forms of photo-induced skin cancer, are also linked to acute and chronic sun exposure. The only known strategies aimed at preventing photo-ageing include sun avoidance, using sunscreens to block or reduce skin exposure to UV radiation, using retinoids to inhibit collagenase synthesis and to promote collagen production, and using anti-oxidants, particularly in combination, to reduce and neutralize free radicals.

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“…Similarly, Benedetto et al 15 demonstrated persistence of this distinct zone of horizontally arranged new collagen up to 8 years after dermabrasion. In another study, 19 a 270% increase in dermal procollagen was demonstrated 12 weeks after dermabrasion.…”

Section: Commentmentioning

confidence: 83%