Clinical impact of positive Propionibacterium acnes cultures in orthopedic surgery

Lavergne, Valéry; Malo, Michel; Gaudelli, C.; LaPrade, Matthew D.; Leduc, Sylvain; Laflamme, Pierre; Rouleau, Danielle

doi:10.1016/j.otsr.2016.12.005

Cited by 29 publications

(24 citation statements)

References 32 publications

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“…After spinal surgery the FDG-uptake typically normalizes in 4 months [3]. The high FDG uptake in infection primarily depends on the high metabolism of accumulated, activated inflammatory cells and the increased vascular permeability at the site of bacterial infection [3][4][5].…”

Section: Discussionmentioning

confidence: 99%

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FDG-PET/CT Limitations in the Diagnosis of Spinal Implant Infection

Bolander¹,

Åkerlund²,

Axelsson³

2019

J Med Imaging Case Rep

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Section: Discussionmentioning

confidence: 99%

“…C. acnes is slow growing in vitro and has an expected low virulence which make these infections difficult to diagnose. It also has a high risk of reoccurrence [1,5]. We consider all these factors to contribute to the case relevancy.…”

Section: Medical Imaging and Case Reportsmentioning

confidence: 99%

FDG-PET/CT Limitations in the Diagnosis of Spinal Implant Infection

Bolander¹,

Åkerlund²,

Axelsson³

2019

J Med Imaging Case Rep

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“…P . acnes is a common human skin-associated organism and had been previously shown as the cause of orthopedic infections 14, 15 . It will be highly important to limit the impact of such contaminations as P .…”

Section: Discussionmentioning

confidence: 99%

Targeted next-generation sequencing of the 16S-23S rRNA region for culture-independent bacterial identification - increased discrimination of closely related species

Sabat

Zanten

Akkerboom

et al. 2017

Sci Rep

120

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The aim of this study was to develop an easy-to-use culture-free diagnostic method based on next generation sequencing (NGS) of PCR amplification products encompassing whole 16S-23S rRNA region to improve the resolution of bacterial species identification. To determine the resolution of the new method 67 isolates were subjected to four identification methods: Sanger sequencing of the 16S rRNA gene; NGS of the 16S-23S rRNA region using MiSeq (Illumina) sequencer; Microflex MS (Bruker) and VITEK MS (bioMérieux). To evaluate the performance of this new method when applied directly on clinical samples, we conducted a proof of principle study with 60 urine samples from patients suspected of urinary tract infections (UTIs), 23 BacT/ALERT (bioMérieux) positive blood culture bottles and 21 clinical orthopedic samples. The resolution power of NGS of the 16S-23S rRNA region was superior to other tested identification methods. Furthermore, the new method correctly identified pathogens established as the cause of UTIs and blood stream infections with conventional culture. NGS of the 16S-23S rRNA region also showed increased detection of bacterial microorganisms in clinical samples from orthopedic patients. Therefore, we conclude that our method has the potential to increase diagnostic yield for detection of bacterial pathogenic species compared to current methods.

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“…P. acnes infections have been reported in the orthopedic literature, particularly after shoulder surgery, although there is some controversy over whether this phenomenon is only associated with surgical implants . The virulence of this commensal bacterium is thought to be due to its ability to form biofilms and its production of a number of enzymes that can destroy host tissue .…”

Section: Discussionmentioning

confidence: 99%

“…6 P. acnes infections have been reported in the orthopedic literature, particularly after shoulder surgery, although there is some controversy over whether this phenomenon is only associated with surgical implants. [7][8][9] The virulence of this commensal bacterium is thought to be due to its ability to form biofilms and its production of a number of enzymes that can destroy host tissue. 10 A case series of P. acnes infections in patients with temporomandibular joint prostheses has also been reported within the field of otolaryngology, although the patients in that study presented with mild symptoms of infection rather than significant osteomyelitis.…”

Section: Discussionmentioning

confidence: 99%

Propionibacterium acnes as an emerging pathogen in skull base osteomyelitis: A case series

2017

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Skull base osteomyelitis (SBO) is recognized as a potentially life-threatening infection that has been classically attributed to Pseudomonas aeruginosa. However, growing data shows that the bacteriology of SBO is changing. Traditionally thought of as commensal bacterium, P. acnes has been implicated as a serious pathogen in other specialties. Building on a previous case report from our institution, we have identified three patients with SBO who are culture-positive for Propionibacterium acnes as a single isolate. Herein, we describe the clinical history of the three patients, along with treatment, present outcome, and review of the literature. Laryngoscope, 128:332-335, 2018.

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Clinical impact of positive Propionibacterium acnes cultures in orthopedic surgery

Abstract: Level IV retrospective case series.

Cited by 29 publications

References 32 publications

FDG-PET/CT Limitations in the Diagnosis of Spinal Implant Infection

FDG-PET/CT Limitations in the Diagnosis of Spinal Implant Infection

Targeted next-generation sequencing of the 16S-23S rRNA region for culture-independent bacterial identification - increased discrimination of closely related species

Propionibacterium acnes as an emerging pathogen in skull base osteomyelitis: A case series

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