Clinical impact of controlling nutritional status score on the prognosis of patients with diffuse large B‐cell lymphoma

Nagata, Akihito; Kanemasa, Yusuke; Sasaki, Yuki; Nakamura, Shohei; Okuya, Toshihiro; Funasaka, Chikako; Kageyama, Akihiko; Shimoyama, Tatsu; Omuro, Yasushi

doi:10.1002/hon.2732

Cited by 28 publications

(50 citation statements)

References 76 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Poor nutritional status is correlated with the toxicity of chemotherapy, resulting in treatment reduction or interruption 17 . The present ndings were consistent with previous reports in other hematological malignancies, which showed the signi cant prognostic utility of the CONUT score in adult T-cell leukemia/lymphoma (ATLL) 11 , DLBCL 12,13 , multiple myeloma 14,15 , myelodysplastic syndrome (MDS), and acute myeloid leukemia (AML) 16 . This study is the rst to con rm the prognostic impact of the CONUT score in patients with PTCL.…”

Section: Discussionsupporting

confidence: 93%

“…Similarly, the optimal cut-off value of the CONUT score using the ROC curve for predicting the OS of PTCL was 5, the AUC was 0.629 (95% CI 0.519-0.740), sensitivity was 50.9%, and speci city was 77.3%. Nagata et al reported the usefulness of the CONUT score in DLBCL; using an ROC curve with a cut-off value of 4, the AUC was 0.71 (95% CI 0.59-0.78), sensitivity was 59.3%, and speci city was 77.8% 12 . Sakurai et al also reported the utility of the CONUT score in MDS and AML; using an ROC curve with a cut-off value of 5, the AUC was 0.71 (95% CI 0.59-0.83), sensitivity was 84.4%, and speci city was 60.9%.…”

Section: Discussionmentioning

confidence: 99%

“…The median age at diagnosis was 67 (range 16-87) years, and the most common pathological diagnosis was PTCL not otherwise speci ed (PTCL-NOS) (n = 65), followed by angioimmunoblastic T-cell lymphoma (AITL) (n = 13) and anaplastic large cell lymphoma kinase (ALK)-positive anaplastic large cell lymphoma (ALCL) (n = 10). The median CONUT score was 3 (0-12), and nutritional status was normal (0-1), mild (2-4), moderate (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18), and severe (9-12) in 16 (16.2%), 45 (45.5%), 23 (23.3%), and 15 (15.2%) patients, respectively. Forty-four patients (44.4%) received CHOP, 43 patients (43.4%) received THP-COP (CPA, tetrahydropyranyl adriamycin, VCR, OSL), and 10 patients (10.1%) received best supportive care (BSC).…”

Section: Patients' Characteristicsmentioning

confidence: 99%

“…Several cohort studies have reported that the CONUT score is an independent prognostic factor in solid cancer patients 10 . In several haematological malignancies, including B-cell lymphoma, leukemia, and myeloma [11][12][13][14][15][16] , the CONUT score provided useful prognostic information. However, it remains unclear whether nutritional status has a clinical impact in patients with PTCL.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Prognostic Impact of the Controlling Nutrition Status Score in Patients With Peripheral T-cell Lymphoma

Nakamura

Kanemura

Lee

et al. 2021

Preprint

View full text Add to dashboard Cite

The controlling nutritional status (CONUT) is a simplified nutritional index calculated from serum albumin, total cholesterol, and the total lymphocyte count. Although the CONUT score is an independent prognostic factor in several hematological malignancies, the prognostic impact of the CONUT score in peripheral T-cell lymphoma (PTCL) is unclear. This study evaluated the prognostic impact of the CONUT score on overall survival (OS) in patients with PTCL. A multicentre, retrospective, cohort study including 99 patients with PTCL was conducted. The CONUT score was significantly higher in the non-survivor group (median 5, range 0-12) than in the survivor group (median 3, range 0-11) (P = 0.026). The CONUT score was an independent prognostic factor in a multivariable Cox proportional hazards model (hazard ratio 1.118, 95% confidence interval 1.020-1.225, P = 0.017). The Cox proportional hazards model with restricted cubic spline showed an S-shaped relationship between the CONUT score and OS. No significant effect-modification by the International Prognostic Index (IPI) was observed, and the CONUT score affected the prognosis of PTCL regardless of the IPI (P for interaction = 0.208). In conclusion, the CONUT score is an independent prognostic factor in patients with PTCL irrespective of IPI categories.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Patients' Characteristicsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prognostic Impact of the Controlling Nutrition Status Score in Patients With Peripheral T-cell Lymphoma

Nakamura

Kanemura

Lee

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…The nutritional status assessments using GNRI; BMI and serum level of Alb, PNI; serum level of Alb and TLC, and CONUT score; serum level of Alb, TLC and T-chol, are developed to predict tolerability to cancer treatment in the elderly patients with solid tumors 3,4,[15][16][17] . Recently, the CONUT score has been shown to predict prognosis in patients with some hematological malignancies [5][6][7][8] . However, the prognostic value in AML remained to be determined.…”

Section: Discussionmentioning

confidence: 99%

A novel nutritional index “simplified CONUT” and the disease risk index independently stratify prognosis of elderly patients with acute myeloid leukemia

Senjo

Onozawa

Hidaka

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Elderly patients aged 65 or older with acute myeloid leukemia (AML) have poor prognosis. The risk stratification based on genetic alteration has been proposed in national comprehensive cancer network (NCCN) guideline but its efficacy was not well verified especially in real world elderly patients. The nutritional status assessment using controlling nutritional status (CONUT) score is a prognostic biomarker in elderly patients with solid tumors but was not examined in elderly AML patients. We performed prospective analysis of genetic alterations of 174 patients aged 65 or older with newly diagnosed AML treated without hematopoietic stem cell transplantation (HSCT) and developed simplified CONUT (sCONUT) score by eliminating total lymphocyte count from the items to adapt AML patients. In this cohort, both the NCCN 2017 risk group and sCONUT score successfully stratified the overall survival (OS) of the elderly patients. A multivariable analysis demonstrated that adverse group in NCCN 2017 and high sCONUT score were independently associated with poor 2-year OS. Both risk stratification based on NCCN 2017 and sCONUT score predict prognosis in the elderly patients with newly diagnosed AML.

show abstract

A controlling nutritional status score is an independent predictor for patients with newly diagnosed nasal‐type extranodal NK/T‐cell lymphoma based on asparaginase‐containing regimens

Ren

Chen

et al. 2023

Cancer Medicine

View full text Add to dashboard Cite

Background The controlling nutritional status (CONUT) score is a nutritional index that combines serum albumin, total cholesterol, and lymphocyte counts. The potential value of CONUT score for predicting clinical outcomes in patients with nasal‐type extranodal NK/T‐cell lymphoma (ENKTL) has not been explored. Methods This study included 374 ENKTL patients treated with asparaginase‐containing regimens from September 2012 to September 2017. Clinical characteristics, treatment efficacy, prognostic factors, and the predictive value of CONUT score were analyzed. Results The complete response (CR) and overall response rate (ORR) were 54.8% and 74.6%, respectively. Patients with CONUT scores <2 had higher CR and ORR compared to patients with scores ≥2 (69.1% vs. 48.9% for CR, p = 0.001; 90.0% vs. 74.6% for ORR, p < 0.001). The 5‐year overall survival (OS) and progression‐free survival (PFS) rates were 61.9% and 57.3%, respectively. Patients with CONUT scores <2 had better survival outcomes than those with scores ≥2 (5‐year OS, 76.1% vs. 56.0%, p < 0.001; 5‐year PFS, 74.4% vs. 50.1%, p < 0.001). CONUT score ≥2 was identified as an independent poor prognostic factor for both OS and PFS. A CONUT score ≥2 was also associated with poorer survival outcomes in low‐risk ENKTL patients. Conclusion A CONUT score ≥2 is a prognostic marker for poor survival in patients with ENKTL and could be used to stratify risk in low‐risk patients.

show abstract

Clinical impact of controlling nutritional status score on the prognosis of patients with diffuse large B‐cell lymphoma

Cited by 28 publications

References 76 publications

Prognostic Impact of the Controlling Nutrition Status Score in Patients With Peripheral T-cell Lymphoma

Prognostic Impact of the Controlling Nutrition Status Score in Patients With Peripheral T-cell Lymphoma

A novel nutritional index “simplified CONUT” and the disease risk index independently stratify prognosis of elderly patients with acute myeloid leukemia

A controlling nutritional status score is an independent predictor for patients with newly diagnosed nasal‐type extranodal NK/T‐cell lymphoma based on asparaginase‐containing regimens

Contact Info

Product

Resources

About