Clinical Immunology, Allergy and Photoimmunology

Spickett, GP; Schwarz, Thomas

doi:10.1002/9780470750520.ch10

Cited by 2 publications

(21 citation statements)

References 93 publications

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“…30,31 The immunosuppressive effects of UVR are mostly due to the medium wavelengths (UVB), but the long wavelengths (UVA) also influence immune reactions. 32,33 UVB mainly affects epidermal keratinocytes and Langerhans cells (LCs), but the ability of UVA to penetrate deeper into the dermis allows it to also impact dermal fibroblasts, dermal dendritic cells, endothelial cells, and skin-infiltrating inflammatory cells such as T lymphocytes, mast cells, and granulocytes. 34 UVR induces antigen-specific, long-term immunosuppression.…”

Section: Beyond Dna Mutagenesis: Damage Of Other Molecular Targetsmentioning

confidence: 99%

“…34 UVR induces antigen-specific, long-term immunosuppression. 32,33 It alters local immune responses but also causes systemic immunosuppression via the release of circulating mediators by the UV-stimulated keratinocytes. 32,33 Additionally, despite its known effects being mostly on the acquired immune system, UVR also seems to influence innate immunity.…”

Section: Beyond Dna Mutagenesis: Damage Of Other Molecular Targetsmentioning

confidence: 99%

“…32,33 It alters local immune responses but also causes systemic immunosuppression via the release of circulating mediators by the UV-stimulated keratinocytes. 32,33 Additionally, despite its known effects being mostly on the acquired immune system, UVR also seems to influence innate immunity. 32 UVR-induced immunosuppression is largely responsible for the therapeutic effects of phototherapy in many inflammatory dermatoses and lymphoproliferative skin diseases.…”

Section: Beyond Dna Mutagenesis: Damage Of Other Molecular Targetsmentioning

confidence: 99%

“…32,33 Additionally, despite its known effects being mostly on the acquired immune system, UVR also seems to influence innate immunity. 32 UVR-induced immunosuppression is largely responsible for the therapeutic effects of phototherapy in many inflammatory dermatoses and lymphoproliferative skin diseases. 34 However, By disturbing the mechanisms of tumor immunosurveillance, it is also involved in photocarcinogenesis.…”

Section: Beyond Dna Mutagenesis: Damage Of Other Molecular Targetsmentioning

confidence: 99%

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The dark side of the light: mechanisms of photocarcinogenesis

Coelho

Matos

Apetato

2016

Clinics in Dermatology

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Ultraviolet radiation (UVR) can have a beneficial biologic impact on skin, but it is also the most significant environmental risk factor for skin cancer development. Photocarcinogenesis comprises a complex interplay between the carcinogenic UVR, skin, and the immune system. UVB is absorbed by the superficial skin layers and is mainly responsible for direct DNA damage, which, if unrepaired, can lead to mutations in key cancer genes. UVA is less carcinogenic, penetrates deeper in the dermis, and mainly causes indirect oxidative damage to cellular DNA, proteins, and lipids, via photosensitized reactions. UVR not only induces mutagenesis, altering proliferation and differentiation of skin cells, but also has several immunosuppressive effects that compromise tumor immunosurveillance by impairing antigen presentation, inducing suppressive cells, and modulating the cytokine environment. This review focuses upon molecular and cellular effects of UVR, regarding its role in skin cancer development.

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Section: Beyond Dna Mutagenesis: Damage Of Other Molecular Targetsmentioning

confidence: 99%

Section: Beyond Dna Mutagenesis: Damage Of Other Molecular Targetsmentioning

confidence: 99%

Section: Beyond Dna Mutagenesis: Damage Of Other Molecular Targetsmentioning

confidence: 99%

Section: Beyond Dna Mutagenesis: Damage Of Other Molecular Targetsmentioning

confidence: 99%

See 2 more Smart Citations

The dark side of the light: mechanisms of photocarcinogenesis

Coelho

Matos

Apetato

2016

Clinics in Dermatology

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“…In fact, because UVR suppresses the immune system in a more specific fashion, phototherapy can have fewer side effects than conventional, broader immunosuppressive drugs. 3 The dark side of the light: adverse effects of phototherapy…”

Section: The Bright Side Of the Light: Uvr As Treatmentmentioning

confidence: 99%

The dark side of the light: Phototherapy adverse effects

Coelho

Apetato

2016

Clinics in Dermatology

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Phototherapy is a valuable therapeutic tool in Dermatology, but there may be drawbacks. Acute and long-term adverse effects, of variable severity, include skin erythema, xerosis, pruritus, blistering, altered pigmentation, photoaging, and photocarcinogenesis. Despite concerns over the carcinogenic potential of ultraviolet radiation, most studies have not found an increased risk of non-melanoma or melanoma skin cancer in patients treated with ultraviolet B (broadband and narrowband) and ultraviolet A1 phototherapy. These are therefore considered reasonably safe treatment modalities concerning the development of skin neoplasms, although caution and further investigation are warranted. Photoprotective measures, such as avoidance of concurrent sunlight exposure and covering skin areas not afflicted with disease, or more modern strategies, including phytochemical antioxidants and exogenous DNA repair enzymes, can minimize the hazards of phototherapy. Patients submitted to phototherapeutic regimens should undergo complete, careful dermatologic examination regularly and lifelong.

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Clinical Immunology, Allergy and Photoimmunology

Cited by 2 publications

References 93 publications

The dark side of the light: mechanisms of photocarcinogenesis

The dark side of the light: mechanisms of photocarcinogenesis

The dark side of the light: Phototherapy adverse effects

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