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Cited by 152 publications
(219 citation statements)
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“…The XR (gp91 phox [phagocyte oxidase]) form of CGD is clinically more severe than the AR p47 phox -deficient form (7,9,17). AR p22 phox and p67 phox deficiencies appear to be as severe as XR CGD (18,19). Patients are routinely placed on prophylactic antimicrobial therapy, and the only curative treatment widely available is allogeneic hematopoietic stem cell transplantation (HSCT) (20).…”
Section: Introductionmentioning
confidence: 99%
“…The XR (gp91 phox [phagocyte oxidase]) form of CGD is clinically more severe than the AR p47 phox -deficient form (7,9,17). AR p22 phox and p67 phox deficiencies appear to be as severe as XR CGD (18,19). Patients are routinely placed on prophylactic antimicrobial therapy, and the only curative treatment widely available is allogeneic hematopoietic stem cell transplantation (HSCT) (20).…”
Section: Introductionmentioning
confidence: 99%
“…Frequently, Staphylococcus aureus is the responsible organism and it can be detected with needle biopsy (1). Patients with residual NADPH oxidase activity in neutrophiles give clinical findings in later periods and less intense infections when compared with those who do not have activity (7). Our third case did not have any serious infection and he was presented with Staphylococcus aureus-induced liver abscess in the adolescence.…”
Section: Discussionmentioning
confidence: 62%
“…CGD patients are at an increased risk of colitis and discoid lupus, in addition to arthritis, although the latter is rarely reported (Winkelstein et al 2000;De Ravin et al 2008;van den Berg et al 2009). There are case reports as well as entries in large registries that have previously reported arthritis developing after the diagnosis of CGD (Lee and Yap 1994;De Ravin et al 2008;van den Berg et al 2009;Koker et al 2013;Magnani et al 2014). There are 7 patients reported with arthritis, and only 3 with systemic lupus erythematosus (SLE), found in various large registries of CGD patients.…”
Section: Discussionmentioning
confidence: 99%
“…Autoimmune manifestations reported in CGD include Lupus Syndromes (Discoid Lupus Erythematous and Systemic Lupus erythematous), idiopathic/ immune thrombocytopenia, myasthenia gravis, sarcoidosis, IgA nephropathy, steroid responsive pericardial effusion, anti-phospholipids syndrome and autoimmune hepatitis (Schmitt et al 1995;Macedo et al 1999;Winkelstein et al 2000;De Ravin et al 2006van den Berg 2009;Koker et al 2013). …”
Section: Introductionmentioning
confidence: 99%
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