Clinical features of schizophrenia associated with idiopathic unconjugated hyperbilirubinemia (Gilbert's Syndrome)

Miyaoka, Tsuyoshi; Yasukawa, Rei; Mizuno, Sohichi; Sukegawa, Tsuruhei; Inagaki, Takuji; Horiguchi, Jun

doi:10.1080/13651500310001455

Cited by 14 publications

(11 citation statements)

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“…Again there was a statistically significant decline in the total bilirubin with treatment but it is not documented which patients experienced an improvement in their mental state. This was confirmed in a later comparative study by Miyaoka et al [8] that showed significantly higher positive PANSS scores during acute psychosis in patients with Gilbert's syndrome. There was no difference on the negative subscale.…”

Section: Introductionsupporting

confidence: 60%

Gilbert's syndrome in a patient with predominantly negative symptoms of schizophrenia

Powell

Hansen

2007

International Journal of Psychiatry in Clinical Practice

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Idiopathic unconjugated hyperbilirubinemia (Gilbert's syndrome) is a common genetic enzyme deficiency found in 3-10% of the general population. It occurs with greater frequency in patients with schizophrenia. We report the case of a young man with mainly negative symptoms of schizophrenia in whom there has been little improvement in mental state with prolonged treatment despite an improvement in total bilirubin, contrary to other published cases. We examine the literature related to Gilbert's syndrome and symptom severity and we discuss the research into the pathophysiology of schizophrenia in Gilbert's syndrome and negative symptom schizophrenia.

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Section: Introductionsupporting

confidence: 60%

Gilbert's syndrome in a patient with predominantly negative symptoms of schizophrenia

Powell

Hansen

2007

International Journal of Psychiatry in Clinical Practice

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“…On the other hand, at stable state, both positive and negative symptoms have been shown to covary with elevated bilirubin [12] , a fi nding that might be confi ned to schizophrenia rather than ATPD patients who are supposed to fully recover after acute psychosis (although note that full recovery is diffi cult to operationalise, [7] ). More importantly, diff erent aetiology of acute psychoses and schizophrenia has been proposed and might account for diff ering bilirubin levels.…”

Section: Diagnosismentioning

confidence: 98%

Elevated Bilirubin in Acute and Transient Psychotic Disorder

2009

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“…significant characteristic clinical differences between schizophrenic patients with GS and without GS [10,11]. Dalman and Cullberg reported that neonatal hyperbilirubilirubinemia might be a vulnerability factor for mental disorder [12].…”

Section: Introductionmentioning

confidence: 99%

“…Dalman and Cullberg reported that neonatal hyperbilirubilirubinemia might be a vulnerability factor for mental disorder [12]. Further from the viewpoint of the heterogeneity of schizophrenia, there may be a poorer prognosis for the subtype of schizophrenia with GS [10].…”

Section: Introductionmentioning

confidence: 99%

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Schizophrenia and Idiopathic Unconjugated Hyperbilirubinemia (Gilberts Syndrome)

Miyaoka¹,

Horiguchi

2005

CPSR

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Idiopathic unconjugated hyperbilirubinemia (Gilbert's syndrome, GS) is a relatively common congenital hyperbilirubinemia occurring in 3-7% of the world population. It has been recognized as a benign familial condition in which hyperbilirubinemia occurs in the absence of structural liver disease or hemolysis, and the plasma concentration of conjugated bilirubin is normal. Recently, it was reported that unconjugated bilirubin had neurotoxicity in the developing nervous system. The 'neurodevelopmental hypothesis' of schizophrenia was proposes that a yet-unidentified event occurring in utero or early postnatal life. We have observed that patients suffering from schizophrenia frequently present an increased bilirubin plasma concentration when admitted to the hospital. Therefore, we had notice the relation between unconjugated bilirubin and the etiology and vulnerability of schizophrenia.

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Clinical features of schizophrenia associated with idiopathic unconjugated hyperbilirubinemia (Gilbert's Syndrome)

Cited by 14 publications

References 0 publications

Gilbert's syndrome in a patient with predominantly negative symptoms of schizophrenia

Gilbert's syndrome in a patient with predominantly negative symptoms of schizophrenia

Elevated Bilirubin in Acute and Transient Psychotic Disorder

Schizophrenia and Idiopathic Unconjugated Hyperbilirubinemia (Gilberts Syndrome)

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