Clinical Features of Patients With Kawasaki Disease Whose Parents Had the Same Disease

Abstract

Some cases of Kawasaki disease show familial susceptibility to the disorder. Family history, especially parental history of Kawasaki disease, may be an indicator of disease severity.

Poor response to intravenous immunoglobulin in patients with a parental history of Kawasaki disease

“…Despite the higher CRP levels in the PHK group, the incidence of CAA was not different between the PHK and NPHK groups. The reason for the difference in the incidence of CAA of this study from previous report 3 might be due to the effects of PE therapy.…”

“…A previous report showed a high incidence of CAA 1 month after the onset of disease in patients whose parents had a history of KD: 12% in patients whose parents had KD and 5.3% in patients with no parental history. 3 In the current study, the incidence of CAA was not different between the PHK and NPHK groups. Another report showed the outcomes of PE therapy for KD refractory to IVIG were favorable and the outcomes of PE therapy tended to be better when PE therapy was begun in the early stage.…”

“…This study was not able to show any clinical significance regarding the sex of parents and children within the PHK group. The male–female ratio of patients whose parent had a history of KD was 4.3 in this study and 1.4 in the nationwide survey data from 1999–2016 1,3,8–15 . The reason for this difference is not known.…”

“…A previous report showed a high incidence of IVIG retreatment in patients whose parents had a history of KD: 29% in patients whose parents had KD and 12% in patients with no parental history. 3 In this study, the incidence of patients with refractory IVIG differed between the PHK and NPHK groups.…”

Clinical Characteristics of Patients With Kawasaki Disease Whose Siblings Had the Same Disease

“…The familial agglomeration of KD may suggest the involvement of genetic backgrounds. 7,20,21 However, our results showed that among patients with a sibling history, no independent factors were associated with parental history of KD (Table 3). The potential genetic factors may be separately associated with high susceptibility to KD onset and disease severity.…”