2016
DOI: 10.1136/bmj.i1901
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Abstract: Objective To report radiological findings observed in computed tomography (CT) and magnetic resonance imaging (MRI) scans of the first cases of congenital infection and microcephaly presumably associated with the Zika virus in the current Brazilian epidemic.Design Retrospective study with a case series.Setting Association for Assistance of Disabled Children (AACD), Pernambuco state, Brazil.Participants 23 children with a diagnosis of congenital infection presumably associated with the Zika virus during the Bra… Show more

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Cited by 310 publications
(274 citation statements)
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“…Craniofacial disproportion and microcephaly (HC < 32 cm) are seen in almost all brain MRI studies [25][26][27].…”
Section: Neonatal Brain Mrimentioning
confidence: 99%
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“…Craniofacial disproportion and microcephaly (HC < 32 cm) are seen in almost all brain MRI studies [25][26][27].…”
Section: Neonatal Brain Mrimentioning
confidence: 99%
“…It is severe (i.e., agyria) in about 80 % of cases. Other malformations described in the literature include polymicrogyria, heterotopia, and schizencephaly; (4) cerebellar and brainstem hypoplasia may also be noted in approximately 75 % and 10 % of cases, respectively; (5) white-matter hypodensity is seen in almost all neonates and is diffuse in near 90 % of them; no further characterization of white matter changes is possible on CT, but MRI studies suggest that white matter changes seen on CT are due to dysmyelination or delayed myelination; (6) chronic encephalomalacia is reported in one case in the territory of the middle cerebral artery (MCA) which is most likely caused by sequelae of prenatal ischemic stroke in early intrauterine life; (7) skull molding with a pointed occiput and overriding of bones mainly in the frontal and occipital regions is another described feature in head CT scans of affected neonates [24][25][26][27].…”
Section: Neonatal Brain Ct Scan (Fig 1)mentioning
confidence: 99%
“…Congenital cytomegalovirus can produce a similar phenotype, although the location of the intracranial calcifications may differ 3, 4. The symptoms of the distinctive phenotype of congenital Zika syndrome are severe microcephaly with a collapsed skull and prominent scalp rugae, profound craniofacial disproportion, exuberant external occipital protuberance, brain calcifications in the junction between cortical and subcortical white matter, and malformations of cortical development, often with a simplified gyral pattern and predominance of pachygyria or polymicrogyria in the frontal lobes.…”
Section: Discussionmentioning
confidence: 99%
“…The symptoms of the distinctive phenotype of congenital Zika syndrome are severe microcephaly with a collapsed skull and prominent scalp rugae, profound craniofacial disproportion, exuberant external occipital protuberance, brain calcifications in the junction between cortical and subcortical white matter, and malformations of cortical development, often with a simplified gyral pattern and predominance of pachygyria or polymicrogyria in the frontal lobes. Additional findings are enlarged cisterna magna, abnormalities of corpus callosum (hypoplasia or hypogenesis), ventriculomegaly, delayed myelination, and hypoplasia of the cerebellum and the brainstem 3, 4…”
Section: Discussionmentioning
confidence: 99%
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