Clinical Features and Independent Prognostic Factors for Acute Bacterial Meningitis in Adults

Vibha, Deepti; Bhatia, Rohit; Prasad, Kameshwar; Srivastava, M. V. Padma; Tripathi, Manjari; Singh, Mamta Bhushan

doi:10.1007/s12028-010-9396-4

Cited by 10 publications

(6 citation statements)

References 23 publications

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“…In the present study, older age was also considered as a factor of a negative prognosis, confirming the results of previous studies. Nevertheless, the age of participants considered in previous studies was higher than in our study 29,30 .…”

Section: Discussioncontrasting

confidence: 70%

“…In this study, multibacterial meningitis was not related to an increased rate of mortality, although the number of participants was small. Multibacterial infection is reported as a negative prognostic factor by some authors 6,29,30 . In the present study, the dynamics of the CSF lactate concentration in patients with multibacterial meningitis showed a peak of CSF lactate in those samples with positive bacterial cultures.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of cerebrospinal fluid lactate with physical, cytological, and other biochemical characteristics as prognostic factors in acute bacterial meningitis

Almeida

Barros

Petterle

et al. 2019

Arq. Neuro-Psiquiatr.

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Bacterial meningitis (BM) is associated with a high morbidity and mortality. Cerebrospinal fluid (CSF) lactate may be used as a prognostic marker of this condition. We hypothesized that CSF lactate levels would remain elevated in participants who died of acute BM compared with those who recovered from this disease. Objective: To evaluate the potential use of lactate and other CSF biomarkers as prognostic markers of acute BM outcome. Methods: This retrospective, longitudinal study evaluated dynamic CSF biomarkers in 223 CSF samples from 49 patients who fulfilled the inclusion criteria of acute BM, with bacteria identified by CSF culturing. The participants were grouped according to outcome: death (n = 9; 18.37%) and survival (n = 40; 81.63%). All participants received appropriate antibiotic treatment. Results: In the logistic regression model, lactate concentration in the final CSF sample, xanthochromia, and CSF glucose variation between the first and last CSF samples were predictors of a poor outcome (death). In contrast, decrease in CSF white blood cell count and CSF percentage of neutrophils, increase in the percentage of lymphocytes, and normalization of the CSF lactate concentration in the last CSF sample were predictors of a good prognosis. Conclusion: The study confirmed the initial hypothesis. The longitudinal analysis of CSF lactate is an important predictor of prognosis in acute BM.

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Section: Discussioncontrasting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Comparison of cerebrospinal fluid lactate with physical, cytological, and other biochemical characteristics as prognostic factors in acute bacterial meningitis

Almeida

Barros

Petterle

et al. 2019

Arq. Neuro-Psiquiatr.

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“…Early symptomatic seizures indicate more severe disease, and recurrent seizures are associated with the development of neurological complications , adverse outcome and increased mortality . Individuals with contracted bacterial meningitis have a 5.4‐fold risk of developing seizures after hospital discharge .…”

Section: Acute Symptomatic Seizures During Cns Infections and Risk For Later Unprovoked Seizuresmentioning

confidence: 99%

Clinical characteristics, risk factors and pre‐surgical evaluation of post‐infectious epilepsy

Sellner

Trinka

2012

Euro J of Neurology

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“…There are many bacterial pathogens that are associated with CNS invasion. Rapid detection of a bacterial agent in such presentations and the initiation of appropriate antibiotic therapy influence morbidity and mortality (8)(9)(10). The clinical presentations of bacterial CNS infection range from meningitis and meningoencephalitis to focal CNS syndromes.…”

mentioning

confidence: 99%

Pathogens Penetrating the Central Nervous System: Infection Pathways and the Cellular and Molecular Mechanisms of Invasion

et al. 2014

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SUMMARY The brain is well protected against microbial invasion by cellular barriers, such as the blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB). In addition, cells within the central nervous system (CNS) are capable of producing an immune response against invading pathogens. Nonetheless, a range of pathogenic microbes make their way to the CNS, and the resulting infections can cause significant morbidity and mortality. Bacteria, amoebae, fungi, and viruses are capable of CNS invasion, with the latter using axonal transport as a common route of infection. In this review, we compare the mechanisms by which bacterial pathogens reach the CNS and infect the brain. In particular, we focus on recent data regarding mechanisms of bacterial translocation from the nasal mucosa to the brain, which represents a little explored pathway of bacterial invasion but has been proposed as being particularly important in explaining how infection with Burkholderia pseudomallei can result in melioidosis encephalomyelitis.

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Clinical Features and Independent Prognostic Factors for Acute Bacterial Meningitis in Adults

Abstract: In the present study, most of the factors predicting death were identified at the time of admission. Identification of these factors could help prioritizing patients needing intensive care facilities, especially in resource poor setting.

Cited by 10 publications

References 23 publications

Comparison of cerebrospinal fluid lactate with physical, cytological, and other biochemical characteristics as prognostic factors in acute bacterial meningitis

Comparison of cerebrospinal fluid lactate with physical, cytological, and other biochemical characteristics as prognostic factors in acute bacterial meningitis

Clinical characteristics, risk factors and pre‐surgical evaluation of post‐infectious epilepsy

Pathogens Penetrating the Central Nervous System: Infection Pathways and the Cellular and Molecular Mechanisms of Invasion

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