Clinical features and independent predictors of pulmonary arterial hypertension in systemic lupus erythematosus

Abstract

Pulmonary arterial hypertension (PAH) is a devastating complication of systemic lupus erythematosus (SLE). We aim to estimate the putative predictors contributing to early identification of PAH, thus improve appropriate medical intervention and a better prognosis. A retrospective case-control study was conducted. Forty-one SLE patients with PAH and 106 SLE patients without PAH were enrolled. Demographic variables, clinical features, and laboratory data were compared between the two groups. Univariate and multivariate logistic regression models were used to examine the predictors contributing to PAH in SLE. Serositis, Raynaud's phenomenon, high disease activity, anticardiolipin antibodies, and anti-U1RNP were significantly associated with SLE-PAH. Univariate and multivariate analysis showed that Raynaud's phenomenon, anticardiolipin antibodies, and anti-U1RNP were independent predictors of PAH in SLE. This study highlighted the clinical pattern of SLE-PAH patients, and underlined the leading predictors of PAH development among patients with SLE. Routine echocardiography is recommended in SLE patients with the independent predictors mentioned above.

Clinical features and outcome of acute exacerbation of interstitial pneumonia associated with connective tissue disease.

“…Parambil et al (23) reported that three patients developed AE to die, among 18 patients with SS-IP (16.6%). And Lian et al (24) reviewed 4038 SLE patients and described that 9.4% of SLE patients associated IP and 1.1% of SLE-IP developed AE. This shows that AE may develop in also SS-IP or SLE-IP.…”

Pulmonary hypertension associated with antiphospholipid antibody: Call for a screening tool?

“…Presence of aPL antibodies was noted in all patients with SLE and PAH (15/15) as compared to only 5/15 in patients with SLE without PAH. Mutiple studies have noted the presence of positive anticardiolipin antibodies (aCL) has a significant association with PAH and SLE patients (18)(19)(20)(21). Similarly Houman et al found out that the frequency of PAH in SLE was higher in patients with antibodies against B2Glycoprotein I (B2GPI) than those without these antibodies (22).…”

Systemic Lupus Erythematosus; Pulmonary Manifestations, a Clinical Study at a University Hospital, Saudi Arabia With Special Reference to High Resolution Computed Tomography (Hrct) Findings

“…(Table-I Anti-Phospholipid Syndrome (APS) is a hype coagulable state, correlation between pulmonary embolism were significantly high in SLE patients who were anti-Cardiolipin antibodies, lupus anticoagulant (LAC) and Beta2 glycoprotein 1 (B2GP1) anti -bodies positive (Table-III), with significant odds ratio (OR), 95% confidence interval (CI), and p-value <0.0001. 4 and others were included. Lung involvement had been investigated in SLE patients previously using various techniques.…”

“…With HRCT, delineation of the lung parenchyma down to the secondary lobule level is possible. 4 The purpose of this study was to evaluate HRCT chest, individual and combination of various patterns of findings in SLE patients.…”