Clinical factors that influence response to treatment strategies in atrial fibrillation: The Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) Study

Curtis, A.B.; Bj, Gersh; Corley, Scott; Jp, DiMarco; Mj, Domanski; Geller, Nancy L.; Hl, Greene; Jc, Kellen; Mickel, Mary; Jd, Nelson; Rosenberg, Yves; Schron, Eleanor B.; Shemanski, Lynn; Al, Waldo; Dg, Wyse; Investigators, Affirm

doi:10.1016/j.ahj.2004.09.038

Cited by 55 publications

(4 citation statements)

References 26 publications

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“…The maintenance of sinus rhythm with AADs was not achieved in all rhythm control patients and not all rate control patients were in AF all the time. When these considerations were taken into account, several post hoc analyses of the AFFIRM data showed that patients who were maintained in sinus rhythm had a better survival rate than those who were in AF [17–19]. It is generally believed that rhythm control with AADs would be preferable for most AF patients if safer and more effective anti-AF drugs were available [2,6,20].…”

Section: Unmet Medical Need and Existing Treatmentmentioning

confidence: 99%

Atrial-selective sodium channel block for the treatment of atrial fibrillation

Burashnikov

Antzelevitch

2009

Expert Opinion on Emerging Drugs

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The pharmacological approach to therapy of atrial fibrillation (AF) is often associated with adverse effects resulting in the development of ventricular arrhythmias. As a consequence, much of the focus in recent years has been on development of atrial-selective agents. Atrial-selective sodium channel blockers have recently been shown to exist and be useful in the management of AF. This review summarizes the available data relative to current therapies, focusing on our understanding of the actions of atrial selective sodium channel blockers in suppressing and preventing the induction of AF and electrophysiological properties that confer atrial-selectivity to these antifibrillatory drugs.

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Section: Unmet Medical Need and Existing Treatmentmentioning

confidence: 99%

Atrial-selective sodium channel block for the treatment of atrial fibrillation

Burashnikov

Antzelevitch

2009

Expert Opinion on Emerging Drugs

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“…Factors that might explain the decreasing mortality trend in AF patients over time include the validation and implementation of different clinical risk scores for stroke prediction, [16] new information on rhythm- and rate-control treatment strategies and on the role of risk factors, [17] , [18] and the dissemination and application of international guidelines for anticoagulation therapy and/or the use of pharmacological or invasive treatment of AF. Adherence to clinical recommendations regarding anticoagulation therapy was described as less than adequate during the study period, but improvements over time are also reported as evidence of how the management of patients differed.…”

Section: Discussionmentioning

confidence: 99%

All-cause mortality trends in patients hospitalized for atrial fibrillation in Sweden: Role of age, stroke risk, and education

Sztaniszlav¹,

Magnuson²,

Bryngelsson³

et al. 2022

IJC Heart & Vasculature

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“… 104 A subsequent metanalysis of 10 studies comparing rhythm vs. rate control strategy in patients with AF aged < 65 years outlined a significant reduction of the composite all-cause-mortality, heart failure, bleeding and thromboembolic events endpoint in the group of patients assigned to rhythm control strategy. 105 …”

Section: Management Of Atrial Fibrillation Of > Durationmentioning

confidence: 99%

ANMCO-SIMEU consensus document: appropriate management of atrial fibrillation in the emergency department

Caldarola

Iaco

Pugliese

et al. 2023

European Heart Journal Supplements

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Atrial fibrillation (AF) accounts for 2% of the total presentations to the emergency department (ED) and represents the most frequent arrhythmic cause for hospitalization. It steadily increases the risk of thromboembolic events and is often associated with several comorbidities that negatively affect patient's quality of life and prognosis. AF has a considerable impact on healthcare resources, making the promotion of an adequate and coordinated management of this arrhythmia necessary in order to avoid clinical complications and to implement the adoption of appropriate technological and pharmacological treatment options. AF management varies across regions and hospitals and there is also heterogeneity in the use of anticoagulation and electric cardioversion, with limited use of direct oral anticoagulants. The ED represents the first access point for early management of patients with AF. The appropriate management of this arrhythmia in the acute setting has a great impact on improving patient's quality of life and outcomes as well as on rationalization of the financial resources related to the clinical course of AF. Therefore, physicians should provide a well-structured clinical and diagnostic pathway for patients with AF who are admitted to the ED. This should be based on a tight and propositional collaboration among several specialists, i.e. the ED physician, cardiologist, internal medicine physician, anesthesiologist. The aim of this ANMCO-SIMEU consensus document is to provide shared recommendations for promoting an integrated, accurate, and up-to-date management of patients with AF admitted to the ED or Cardiology Department, in order to make it homogeneous across the national territory.

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Clinical factors that influence response to treatment strategies in atrial fibrillation: The Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) Study

Cited by 55 publications

References 26 publications

Atrial-selective sodium channel block for the treatment of atrial fibrillation

Atrial-selective sodium channel block for the treatment of atrial fibrillation

All-cause mortality trends in patients hospitalized for atrial fibrillation in Sweden: Role of age, stroke risk, and education

ANMCO-SIMEU consensus document: appropriate management of atrial fibrillation in the emergency department

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