Clinical Experience With Timolol in Childhood Glaucoma

Pediatric glaucoma: current perspectives

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Pediatric glaucoma: current perspectives

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Pharmacological and clinical aspects of glaucoma therapy

“…Topical betablockers and the calcium antagonist verapamil may interact and cause severe bradycardia (Pringle 1987). One must be careful in treating children with topical beta-blockers; attacks of asthma and even apne have been reported (Olsson et al 1979; Williams & Ginther 1982;Hoskins et al 1985). A prodrug of timolol has recently been developed (Chang et al 1988).…”

Betaxolol hydrochloride ophthalmic suspension 0.25% and timolol gel-forming solution 0.25% and 0.5% in pediatric glaucoma: A randomized clinical trial

“…In these, timolol was added as an adjunct to other pressure-reducing medications the children were already taking for their glaucoma. 7,8,13,14 Boger and Walton 13 demonstrated improvement in approximately 26.5% of the subjects and no clear benefit in 38% of the subjects when timolol was added to maximal medical therapy (which consisted of carbonic anhydrase inhibitors, cholinesterase inhibitors, epinephrine, and pilocarpine). Hoskins and colleagues 7 retrospectively evaluated 67 subjects including subjects up to 18 years of age.…”

Pediatric glaucoma: current perspectives

“……”

Pharmacological and clinical aspects of glaucoma therapy

“…Topical betablockers and the calcium antagonist verapamil may interact and cause severe bradycardia (Pringle 1987). One must be careful in treating children with topical beta-blockers; attacks of asthma and even apne have been reported (Olsson et al 1979; Williams & Ginther 1982;Hoskins et al 1985). A prodrug of timolol has recently been developed (Chang et al 1988).…”

Betaxolol hydrochloride ophthalmic suspension 0.25% and timolol gel-forming solution 0.25% and 0.5% in pediatric glaucoma: A randomized clinical trial

“…In these, timolol was added as an adjunct to other pressure-reducing medications the children were already taking for their glaucoma. 7,8,13,14 Boger and Walton 13 demonstrated improvement in approximately 26.5% of the subjects and no clear benefit in 38% of the subjects when timolol was added to maximal medical therapy (which consisted of carbonic anhydrase inhibitors, cholinesterase inhibitors, epinephrine, and pilocarpine). Hoskins and colleagues 7 retrospectively evaluated 67 subjects including subjects up to 18 years of age.…”

Pediatric glaucoma: current perspectives

“……”

Pharmacological and clinical aspects of glaucoma therapy

“…Topical betablockers and the calcium antagonist verapamil may interact and cause severe bradycardia (Pringle 1987). One must be careful in treating children with topical beta-blockers; attacks of asthma and even apne have been reported (Olsson et al 1979; Williams & Ginther 1982;Hoskins et al 1985). A prodrug of timolol has recently been developed (Chang et al 1988).…”

Betaxolol hydrochloride ophthalmic suspension 0.25% and timolol gel-forming solution 0.25% and 0.5% in pediatric glaucoma: A randomized clinical trial

“…In these, timolol was added as an adjunct to other pressure-reducing medications the children were already taking for their glaucoma. 7,8,13,14 Boger and Walton 13 demonstrated improvement in approximately 26.5% of the subjects and no clear benefit in 38% of the subjects when timolol was added to maximal medical therapy (which consisted of carbonic anhydrase inhibitors, cholinesterase inhibitors, epinephrine, and pilocarpine). Hoskins and colleagues 7 retrospectively evaluated 67 subjects including subjects up to 18 years of age.…”