Clinical Evidence of Sustained Chronic Inflammatory Reaction in Retinitis Pigmentosa

Yoshida, Noriko; Ikeda, Yasuhiro; Notomi, Shoji; Ishikawa, Keijiro; Murakami, Yusuke; Hisatomi, Toshio; Enaida, Hiroshi; Ishibashi, Tatsuro

doi:10.1016/j.ophtha.2012.07.006

Cited by 214 publications

(224 citation statements)

References 25 publications

Supporting

Mentioning

202

Contrasting

Unclassified

Order By: Relevance

“…[8][9][10][11][12] We recently demonstrated that (1) aqueous flare values are increased in patients with RP, and (2) increased aqueous flare is correlated with worse central visual function. 13 Together with our previous findings that inflammatory cells and proinflammatory cytokines are substantially increased in the vitreous of RP patients, 14 these findings suggest that chronic inflammation may play a role in the pathology of RP.…”

supporting

confidence: 73%

Association Between Aqueous Flare and Epiretinal Membrane in Retinitis Pigmentosa

Fujiwara

Ikeda

Murakami

et al. 2016

Invest. Ophthalmol. Vis. Sci.

Self Cite

View full text Add to dashboard Cite

PURPOSE. Epiretinal membrane (ERM) is a frequent macular complication in patients with retinitis pigmentosa (RP). The etiology of ERM formation in RP is largely unknown. The purpose of this study was to investigate the association between aqueous flare, a surrogate index of intraocular inflammation, and ERM secondary to RP. METHODS.We retrospectively studied a total of 206 eyes of 117 patients who were diagnosed with typical RP. Aqueous flare values were measured consecutively in 2012 and 2013 using a laser flare cell meter. Spectral-domain optical coherence tomography images and fundus photographs taken on the same day of the aqueous flare measurements were analyzed for ERM detection. RESULTS.The mean values of aqueous flare, age, and frequency of male sex were significantly higher in the RP patients with ERM compared with the RP patients without ERM (P < 0.0001, P ¼ 0.007, and P ¼ 0.004, respectively). After adjustment for age and sex, the eyes in the highest quartile of aqueous flare had significantly higher odds of having ERM than those in the lowest quartile (odds ratio [OR], 2.68; 95% confidence interval [CI], 1.04-6.93), and the linear trend across flare levels was significant (P ¼ 0.005). In addition, each 1-log-transformed increase in flare values was associated with an elevation of the likelihood of having ERM (OR, 2.59; 95% CI, 1.33-5.06).CONCLUSIONS. Our analysis demonstrated that elevated aqueous flare is associated with ERM secondary to RP, suggesting that inflammation may be implicated in the pathogenesis of ERM formation in RP.

show abstract

supporting

confidence: 73%

Association Between Aqueous Flare and Epiretinal Membrane in Retinitis Pigmentosa

Fujiwara

Ikeda

Murakami

et al. 2016

Invest. Ophthalmol. Vis. Sci.

Self Cite

View full text Add to dashboard Cite

show abstract

“…In the eyes of human RP patients, microglial cell infiltration was observed in the transition zone between relatively healthy and degenerated retina, an active region of vision loss (35). We recently reported that the ocular inflammatory levels of RP patients are negatively correlated with visual function (36,37). In animal models of RP, it was shown that microglia migrate into the ONL at the onset of or before photoreceptor cell death (10,38), and the suppression of microglial activation ameliorates photoreceptor cell loss (32).…”

Section: Discussionmentioning

confidence: 99%

“…It also induces cell death through the direct activation of caspases/receptor-interacting protein kinases or indirectly via the activation of inflammatory cells. TNF-α expression is increased in the retinas of animal models of RP, as well as the vitreous of RP patients (10,36). In addition, TNF-α blockade by infliximab suppressed photoreceptor cell death in an in vitro model of RP, indicating the detrimental role of TNF-α in retinal degeneration (48).…”

Section: Discussionmentioning

confidence: 99%

MUTYH promotes oxidative microglial activation and inherited retinal degeneration

et al. 2016

Self Cite

View full text Add to dashboard Cite

“…Biopathologically, low visual acuity is highly correlated with adverse retina health condition [19], which may be affected by shift-works [7,8]. Since chronic circadian rhythm disruption may induce inflammatory reactions, a probable biological explanation for the reduced visual acuity of nighttime workers might be the inflammatory lesions on retina [20,21]. Melatonin, a circadian rhythm hormone, was shown to improve visual function via anti-inflammatory effects [22].…”

Section: Discussionmentioning

confidence: 99%

Night-shift work and risk of compromised visual acuity among the workers in an electronics manufacturing company

Lin

2017

Int J Occup Med Environ Health

View full text Add to dashboard Cite

Objectives: To evaluate the association between night-shift work exposure and visual health, this cross-sectional study utilized visual acuity, a surrogate measure for visual function, as a parameter, and performed an analysis comparing visual acuity between daytime and nighttime employees in an electronics manufacturing company. Material and Methods: Data of personal histories, occupational records, physical examinations and blood tests was obtained from the electronic health records of workers. The total of 8280 workers including 3098 women and 5182 men, wearing their own daily used eyeglasses, were included in the final analysis. The mean age of the sample population was 34.7 years old (standard deviation = 5.4 years). All workers were divided into 3 work categories -consistent daytime worker (CDW), day-shift worker (DSW) and night-shift worker (NSW). The check-up results of glasses-corrected visual acuity (c-VA) were utilized to classify individuals as good (≥ 1.2, both eyes) and inadequate (< 0.8, the better eye) c-VA. Results: Consistent daytime workers had the highest rate of good c-VA (42.5% vs. 25.1% DSW and 21.1% NSW, p = 0.047). Night-shift workers had the highest rate of inadequate c-VA (CDW, DSW and NSW: 2.6%, 6.2%, and 7.6%, p = 0.03) among all employees. After controlling for covariates, NSW were found at an increased risk for inadequate c-VA (adjusted odds ratio (OR a ) = 2.7, 95% confidence interval (CI): 2.0-3.6, vs. CDW), and less likely to have good c-VA (OR a = 0.4, 95% CI: 0.4-0.5, vs. CDW). Conclusions: Night-shift work is moderately associated with compromised visual acuity of employees in this electronics manufacturing company. Int J Occup Med Environ Health 2018;31(1):71 -79

show abstract

Clinical Evidence of Sustained Chronic Inflammatory Reaction in Retinitis Pigmentosa

Cited by 214 publications

References 25 publications

Association Between Aqueous Flare and Epiretinal Membrane in Retinitis Pigmentosa

Association Between Aqueous Flare and Epiretinal Membrane in Retinitis Pigmentosa

MUTYH promotes oxidative microglial activation and inherited retinal degeneration

Night-shift work and risk of compromised visual acuity among the workers in an electronics manufacturing company

Contact Info

Product

Resources

About