Clinical evaluation of the topical use of propolis in recurrent minor aphthous ulceration

Lotufo, Mônica Andrade; Júnior, Celso Augusto Lemos; Shimizu, M. T.; Cabral, Renata; Birman, Esther Goldenberg

doi:10.14295/bds.2005.v8i3.327

Cited by 9 publications

(15 citation statements)

References 9 publications

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“…Bowel disorders, either due to nutritional deficits or gastrointestinal pathology, have also been referred to as triggering causes in different works. 1,25,28,44 Hormonal changes were the least common predisposing factor (7 %), which is consistent with reports by Axéll et al 40 (8 %) and Lotufo et al 41 (2.5 %). In a systematic review carried out by McCartan and Sullivan 45 , no relationship was found between RAS onset and menstrual cycle, pregnancy, menopause or hormone replacement therapy; conversely, some authors 3,7,27,39 have given much higher relevance to this factor.…”

Section: In China Orsupporting

confidence: 89%

“…Stress as a relevant predisposing factor for RAS has been widely suggested in investigations that consider oral mucosa as a target organ in certain emotional disorders. 2,3,19,25,30,32,38,41 The disparity of results around this factor probably lies in the studied sample sizes, type of population and in differences in the investigations' methodological design.…”

Section: In China Ormentioning

confidence: 99%

“…25,42,43 There are analyses where it even is the most important predisposing factor: 50 or 75 % of cases. 41,43 Given the small sample size of those investigations, the results should be regarded as being poorly representative. Furthermore, other particular factors that act with unknown mechanisms should be considered in each patient.…”

Section: In China Ormentioning

confidence: 99%

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Clinical study of 200 patients with recurrent aphthous stomatitis

Rodríguez-Archilla¹,

Raissouni²

2023

GMM

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Introduction: Recurrent aphthous stomatitis (RAS) affects approximately 20% of the general population. Its etiology is still unknown. Objective: To analyze this entity's clinical features. Method: Data such as age, gender, family history of RAS, age at first episode onset, prodromal symptoms, number, size, morphology and localization of lesions, RAS clinical form, annual rate of recurrence, predisposing factors, symptoms and time for symptoms and lesions disappearance were assessed in 200 patients with RAS. Results: Patients had RAS minor forms. Main clinical characteristics were family history of RAS ( 89%), first episode at ≥ 10 years of age (69%), prodromal symptoms (66%), one lesion per episode (63%), < 0.5 cm lesions (64%), rounded morphology (55%), localization at the tongue (27%), 3 recurrent episodes per year (36%), stress as predisposing factor (34%), symptom disappearance in 2 days (54%) and healing of lesions in 8 days (40%). Conclusion: Even when RAS is a common disorder of the oral mucosa, there is no curative treatment available. Therapeutic measures seek to reduce the pain and size of lesions, accelerate the time of recovery and decrease the rate of relapses.

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Section: In China Orsupporting

confidence: 89%

Section: In China Ormentioning

confidence: 99%

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Clinical study of 200 patients with recurrent aphthous stomatitis

Rodríguez-Archilla¹,

Raissouni²

2023

GMM

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“…duração e frequência de recidivas. Concluiu-se que a própolis é bastante eficaz no tratamento desta alteração (Lotufo et al, 2005).…”

Section: Efeito Da Própolis Sobre Ulcerações Aftosas Recorrentesunclassified

Própolis Na Odontologia: Uma Abordagem De Suas Diversas Aplicabilidades Clínicas

Almeida¹

2017

ijosd

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“…It has a bactericide, antimicrobial [5], antioxidant [6], antifungal [7], healing, anti-inflammatory [8], anti-cancerous, anti-HIV [9] and anti-carious biological function [10].…”

Section: Introductionmentioning

confidence: 99%

Biocompatibility of propolis in subcutaneous tissue of rats: a possible biomaterial for cavity cleansing

Almeida

Ferreira

Venâncio

et al. 2017

Rev. Odonto Ciênc. (Online)

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OBJECTIVE: The aim of this study was to histopathologically analyze, in subcutaneous connective tissue in rats, a propolis solution for cavity cleansing and its toxicity through hemolytic and Artemia franciscana tests. METHODS: Fifteen male rats were selected and randomly distributed in three experimental periods (07, 30 and 45 days), in which each animal received the four treatment groups in rounds: Group IPropolis I; Group II -Propolis II; Group III -Calcium Hydroxide Water and Group IV -2% Chlorexidine; the sides of the tube were the control group. The data were analyzed using descriptive statistics. The results showed, in terms of biocompatibility, that all materials presented a significant reduction of the inflammatory infiltrate and an increase of the thickness in the collagen fibers. It may be suggested, in decreasing order of biocompatibility, the use of following materials: calcium hydroxide-water, 2% chlorexidine, propolis I and propolis II. RESULTS: In the cytotoxicity test using A. franciscana, the propolis extract showed high toxicity when tested at concentrations and in the hemolytic activity test the propolis I extract showed greater activity than propolis II. CONCLUSION: The present study suggests the use of propolis as a cavity cleansing solution for shallow and medium cavities similar to 2% chlorexidine.Key words: Materials testing; Propolis; Dental cavity lining; Detergents Biocompatibilidade da própolis no tecido subcutâneo de ratos: um possível biomaterial de limpeza de cavidade RESUMO OBJETIVO: O objetivo deste estudo foi analisar histopatologicamente, em tecido conjuntivo subcutâneo de ratos, uma solução de própolis para a limpeza de cavidades e sua toxicidade através dos testes de hemólise e Artemia franciscana. METODOLOGIA: Foram utilizados 15 ratos machos, selecionados e distribuídos aleatoriamente em três grupos (n=5) em períodos experimentais (7, 30 e 45 dias), em que cada animal recebeu os quatro grupos de tratamento em forma de rodízio: Grupo I -Própolis I; Grupo II -Própolis II; Grupo III -Água de Hidróxido de Cálcio e Grupo IV -Clorexidina a 2%; as laterais do tubo foram o grupo controle. Os dados foram analisados pela estatística descritiva. RESULTADOS: Todos os materiais apresentaram uma redução significativa do infiltrado inflamatório e aumento da espessura das fibras colágenas. No teste de citotoxicidade de Artemia franciscana, o extrato de própolis apresentou alta toxicidade e no teste de atividade hemolítica o extrato de Própolis I mostrou-se mais ativo que o da Própolis II. CONCLUSÃO: O presente estudo mostrou a biocompatibilidade da própolis, sugerindo seu uso como solução de limpeza em cavidade cavidades rasas e médias semelhante à clorexidina a 2%.

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Clinical evaluation of the topical use of propolis in recurrent minor aphthous ulceration

Cited by 9 publications

References 9 publications

Clinical study of 200 patients with recurrent aphthous stomatitis

Clinical study of 200 patients with recurrent aphthous stomatitis

Própolis Na Odontologia: Uma Abordagem De Suas Diversas Aplicabilidades Clínicas

Biocompatibility of propolis in subcutaneous tissue of rats: a possible biomaterial for cavity cleansing

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