Clinical Evaluation of Radiation Therapy in Psoriasis

Harber, Leonard C.

doi:10.1001/archderm.1958.01560050062011

Cited by 19 publications

(9 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies [1,3] as well as the present study have shown a significant effect of grenz ray treatment. (2) It has been questioned whether the use of grenz rays may induce neoplastic skin diseases [2,4].…”

Section: Commentsupporting

confidence: 78%

Effect of Grenz Rays on Psoriasis Treated with Local Corticosteroids

Brodersen¹,

Reymann²

1981

Dermatology

View full text Add to dashboard Cite

show abstract

Section: Commentsupporting

confidence: 78%

Effect of Grenz Rays on Psoriasis Treated with Local Corticosteroids

Brodersen¹,

Reymann²

1981

Dermatology

View full text Add to dashboard Cite

show abstract

“…In many instances grenz rays may be used effectively; infiltrated lesions respond better to soft X rays. Grenz rays are given in three to four separate doses of 200 to 300 R; soft X rays (D1/2 3 to 4 mm, HVL 0.2 to 0.3 mm A1), in three to four fractions of 75 to 150 R at weekly intervals ,,,. In eczematous conditions and in psoriasis the number of courses should not exceed two to three with intervals of at least three months between them.…”

Section: Psoriasismentioning

confidence: 99%

Radiotherapy of Benign Dermatoses: Indications, Practice, and Results

Lukacs¹,

Braun‐Falco²,

Goldschmidt³

1978

The Journal of Dermatologic Surgery and Oncology

View full text Add to dashboard Cite

Limited indications for radiation treatment of benign dermatoses are presented in order to emphasize modern restrictions and techniques in the use of dermatologic radiation therapy and to promote measures of protection against stray radiation. The use of softer, less penetrating X rays, least effective doses and meticulous shielding are recommended. So done, radiation therapy offers an effective therapeutic alternative for conditions that do not respond to other forms of treatment.

show abstract

“…It was noticed that the patients could experience psoriasis exacerbation after hormonal therapy followed by curative radiation therapy of the prostate [7]. It was reported in [8,9,10,11,12,13] that the UV radiation, Grenz rays, and 50 kVp sources were utilized in treatments of psoriasis. In addition, the therapeutic regimen consisted of 6 to 8 treatments of radiographic therapy with a total dose ranging from 4 to 6 Gy for treatment of psoriasis was reported in [14].…”

Section: Purposementioning

confidence: 99%

Custom-made micro applicators for high-dose-rate brachytherapy treatment of chronic psoriasis

Buzurović

O’Farrell

Bhagwat

et al. 2017

jcb

View full text Add to dashboard Cite

PurposeIn this study, we present the treatment of the psoriatic nail beds of patients refractory to standard therapies using high-dose-rate (HDR) brachytherapy. The custom-made micro applicators (CMMA) were designed and constructed for radiation dose delivery to small curvy targets with complicated topology. The role of the HDR brachytherapy treatment was to stimulate the T cells for an increased immune response.Material and methodsThe patient diagnosed with psoriatic nail beds refractory to standard therapies received monthly subunguinal injections that caused significant pain and discomfort in both hands. The clinical target was defined as the length from the fingertip to the distal interphalangeal joint. For the accurate and reproducible setup in the multi-fractional treatment delivery, the CMMAs were designed. Five needles were embedded into the dense plastic mesh and covered with 5 mm bolus material for each micro applicator. Five CMMAs were designed, resulting in the usage of 25 catheters in total.ResultsThe prescription dose was planned to the depth of the anterior surface of the distal phalanx, allowing for the sparing of the surrounding tissue. The total number of the active dwell positions was 145 with step size of 5 mm. The total treatment time was 115 seconds with a 7.36 Ci activity of the 192Ir source. The treatment resulted in good pain control. The patient did not require further injections to the nail bed. After this initial treatment, additional two patients with similar symptoms received HDR brachytherapy. The treatment outcome was favorable in all cases.ConclusionsThe first HDR brachytherapy treatment of psoriasis of the nail bed is presented. The initial experience revealed that brachytherapy treatment was well-tolerated and resulted in adequate control of the disease. A larger cohort of patients will be required for additional conclusions related to the long-term clinical benefits.

show abstract

Clinical Evaluation of Radiation Therapy in Psoriasis

Cited by 19 publications

References 3 publications

Effect of Grenz Rays on Psoriasis Treated with Local Corticosteroids

Effect of Grenz Rays on Psoriasis Treated with Local Corticosteroids

Radiotherapy of Benign Dermatoses: Indications, Practice, and Results

Custom-made micro applicators for high-dose-rate brachytherapy treatment of chronic psoriasis

Contact Info

Product

Resources

About