Clinical evaluation of presepsin considering renal function

Miyoshi, Masashi; Inoue, Yusuke; Nishioka, Mai; Ikegame, Akishige; Nakao, Toshihiro; Nagai, Koujirou

doi:10.1101/604991

Cited by 8 publications

(7 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The optimal cutoff value of PSS for diagnosis of sepsis was higher in patients with AKI than in those without it (828 pg/mL vs 694 pg/mL; P < .001). [27] Miyoshi et al [28] reported that PSS levels in patients with chronic kidney disease were significantly higher than in healthy volunteers. In our study, PSS levels were elevated in accordance with AKI severity.…”

Section: Discussionmentioning

confidence: 99%

Plasma presepsin level predicts acute kidney injury in patients with sepsis in the emergency department

et al. 2022

View full text Add to dashboard Cite

Acute kidney injury (AKI) is a common complication in patients with sepsis. We evaluated the potential prognostic value of plasma presepsin to predict AKI in patients with sepsis in the emergency department. A total of 193 patients diagnosed with sepsis based on the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) were included in this observational study. AKI was defined according to the Kidney Disease Improving Global Outcomes clinical practice guideline. Plasma presepsin levels were measured on admission to the emergency department. We compared plasma presepsin levels between patients who did and those who did not develop AKI. AKI occurred in 100 (51.8%) patients. The median plasma presepsin level was significantly higher in patients with AKI than in those without AKI (1061 pg/mL vs 495 pg/mL, P <.001). Plasma presepsin levels were significantly increased in patients with AKI stage 3 compared with those with AKI stages 1 and 2 (P =.001). The area under the curve of presepsin for predicting AKI was 0.793 (95% confidence interval: 0.729–0.848). The optimal presepsin cutoff value for predicting AKI was >572 pg/mL, with a sensitivity of 77.0% and specificity of 81.7%. Plasma presepsin level is a valuable biomarker for the prediction of AKI in patients with sepsis in the emergency department.

show abstract

Section: Discussionmentioning

confidence: 99%

Plasma presepsin level predicts acute kidney injury in patients with sepsis in the emergency department

et al. 2022

View full text Add to dashboard Cite

show abstract

“…[23] Presepsin, a glycoprotein produced during bacterial phagocytosis, is used as a sepsis marker for bacterial infections [24]. The meta-analysis demonstrates some mortality prediction value in presepsin in patients with sepsis [25].However, presepsin levels are affected by renal function, and the evaluation criteria according to kidney function or in chronic kidney diseases remain controversial [13].Previous studies show that presepsin has potential as a novel biomarker for the early diagnosis of sepsis [12].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, presepsin may represent a novel biomarker for the diagnosis of sepsis. Presepsin concentrations were positively correlated with a few biomarkers of renal function, indicating the necessity to consider the effect of renal function in patients with renal impairment [13].Studies have shown that presepsin level may increase to varying degrees in acute kidney injury (AKI) [1], which limits its use in the diagnosis of sepsis in this patient population. CKD has a high global prevalence with a consistent estimated global CKD prevalence of between 11 to 13% with the majority stage 3 [14].…”

Section: Introductionmentioning

confidence: 99%

The significance of presepsin in chronic kidney disease with sepsis

Wang

Yuan

et al. 2022

Preprint

View full text Add to dashboard Cite

Background: CKD has a high global prevalence with a consistent estimated global CKD prevalence of between 11 to 13% with the majority stage 3. Patients with CKD undergoing hemodialysis have low immunity and are prone to sepsis. Presepsin is a highly specific biomarker for the early diagnosis of sepsis because presepsin is increased in the blood in the early phase of infection and may be a helpful and valuable biomarker in early diagnosis of sepsis. Therefore, presepsin may have application for the early diagnosis of sepsis in patients with CKD.Purpose This prospective study evaluated the diagnostic value of serum presepsin (soluble CD14-ST) levels for sepsis in chronic kidney disease (CKD) and the influence of undergoing hemodialysis on serum presepsin Methods: This study included 291 patients with CKD and 101 patients with normal renal function and sepsis. Presepsin levels were increased in patients with CKD with or without sepsis or hemodialysis compared to controls, and were highest in patients with CKD and sepsis undergoing hemodialysis. Results: Presepsin levels were similar in patients with CKD with sepsis and no hemodialysis and patients with normal renal function and sepsis, but these levels were lower than in patients with CKD without sepsis undergoing hemodialysis. Presepsin, procalcitonin (PCT) and C-reactive protein (CRP) levels had diagnostic value for sepsis; however, presepsin was a better predictor of sepsis than PCT or CRP in patients with CKD not undergoing hemodialysis. Presepsin level had limited diagnostic value for sepsis in patients with CKD undergoing hemodialysis. In CKD complicated with sepsis, presepsin level was significantly correlated with CRP level, Sequential Organ Failure Assessment score, partial pressure of oxygen and body temperature; there was no correlation between presepsin level and these indicators in CKD without sepsis. Conclusion: These findings suggest physicians should incorporate information on biomarkers with medical history, clinical symptoms, physical signs, and other tests related to sepsis for its diagnosis in patients with CKD undergoing hemodialysis. Presepsin was a better predictor of sepsis in patients with CKD not undergoing hemodialysis.

show abstract

“…13 Another study demonstrated that presepsin levels increase with a decrease in glomerular filtration rate )GFR(. 14 Patients with chronic renal failure were not included in our study. However, urea and creatine values were significantly different among the 3 groups in this study.…”

Section: Discussion Limited Studies Have Been Conductedmentioning

confidence: 99%

Prognostic importance of serum presepsin level in pneumonia focal sepsis and its relationship with other biomarkers and clinical severity scores

Özkan

Kahveci

Hür

et al. 2021

SMJ

View full text Add to dashboard Cite

To analyze the prognostic value of serum presepsin value in community-acquired pneumonia focal sepsis using sepsis-3 criteria and its relationship with other biomarkers and clinical severity scores. Methods:For this prospective observational study, 176 patients above 18 years old, diagnosed with community-acquired pneumonia, pneumonia focal sepsis and septic shock were included. It was performed in a tertiary hospital between May 2020 and December 2020. Blood samples were obtained from patients for presepsin levels at the time of diagnosis in the emergency room. The serum presepsin levels of 3 groups were statistically compared with each other. Original ArticleResults: The sepsis group had significantly higher serum presepsin levels than the pneumonia group )p=0.004(.The septic shock group had serum presepsin levels than sepsis group; however, the difference was not statistically significant )p=0.25(. Non survivor patients had significantly higher serum presepsin levels than survivors )p=0.001(. Significant correlation determined between serum presepsin level and procalcitonin, C-reactive protein, lactate, pneumonia severity index, and quick sequential organ failure assessment )qSOFA(. Conclusion:Serum presepsin level is a new biomarker that can be used an indicator of sepsis and mortality in community-acquired pneumonia. However, for determining the prognosis of sepsis, there was no superiority detected over other biomarkers and clinical severity scores.

show abstract

Clinical evaluation of presepsin considering renal function

Cited by 8 publications

References 14 publications

Plasma presepsin level predicts acute kidney injury in patients with sepsis in the emergency department

Plasma presepsin level predicts acute kidney injury in patients with sepsis in the emergency department

The significance of presepsin in chronic kidney disease with sepsis

Prognostic importance of serum presepsin level in pneumonia focal sepsis and its relationship with other biomarkers and clinical severity scores

Contact Info

Product

Resources

About