Clinical Evaluation of Antipruritic Drugs

Cormia, Frank E.

doi:10.1001/archderm.1959.01560140034005

Cited by 10 publications

(3 citation statements)

References 9 publications

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“…One of the reasons for this deficiency is the lack of simple sensitive and reproducible methods of measurement of itch in man. The absolute requirement for rigorous controlled evaluation is pointed up by the strong placebo effect of antipruritic agents, a fact recognized years ago by Cormia and Dougherty [5]. 226 Skin Pharmacol 1997;10:225-229…”

Section: Proposed Anti-itch Treatmentsmentioning

confidence: 99%

Anti-Itch Treatments: Do They Work?

Greaves¹

1997

Skin Pharmacol Physiol

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Section: Proposed Anti-itch Treatmentsmentioning

confidence: 99%

Anti-Itch Treatments: Do They Work?

Greaves¹

1997

Skin Pharmacol Physiol

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“…These methods have been used to study the itch-producing qualities of many chemicals including histamine (Cormia, 1952), kallikrein and bradykinin (Hagermark, 1974), substance P (Hagermark, Hokfelt & Pernow, 1978), prostaglandins (Hagermark & Strandberg, 1977), bile salts (Varadi, 1974;Kirby et al, 1974), cowhage spicules (Shelley & Arthur, 1957) and various proteol3rtic enzjrmes (Hagermark, Rajka& Bergquist, 1972;Hagermark, 1973;Rajka, 1968Rajka, , 1969.…”

Section: Comment 115mentioning

confidence: 99%

“…Here again confusion reigns: Cormia & Kuykendall (1954) felt that the end-point of itching, as contrasted to itch threshold, was not uniform, while Rajka (1968) felt that itch duration techniques were more appropriate and easier to perform than measurement of thresholds, and even more confusingly showed that there was no strict parallelism between itch duration and itch threshold even in the same individual. Cormia (1952) had earlier pointed out the importance other variables such as age (histamine induced weals being liable not to cause itching in subjects over 50), time of day (itch thresholds being decreased at night), psychological stress, and the site tested. All of these have to be taken into account in every study.…”

Section: Comment 115mentioning

confidence: 99%

Do Systemic Antipruritic Agents Work?

Savin¹

1980

Br J Dermatol

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‘Most of the agents recommended for the control of itching during the last two decades have not stood the test of time. Many have been discarded, and the continuing use of several of the remaining ones has been dictated not so much by the results obtained as by the desire to prescribe something for the complaining patient.’ Another 20 years have slipped past since Cormia & Dougherty wrote so bluntly about the subject in 1959. But has the picture really changed? The complaining patients still exist and skin clinics still echo to the rasp of fingernails on skin. There is obviously still a demand for at least one effective antipruritic agent, to be used in conditions like atopic eczema which cannot always be controlled by topical measures, and which cause long‐term distress. This demand is matched by a mass swallowing of drugs reputed to have antipruritic effects—at least 50,000 prescriptions being issued each year in the United Kingdom alone. Yet despite this, skin text books are still coy about confirming that these drugs, usually antihistamines, do in fact suppress itching. Patients are sometimes less complimentary. This review attempts the difficult task of assessing whether, 20 years on, the use of so‐called antipruritic agents is still based upon inadequate evidence.

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Management of AD

Rajka

1989

Essential Aspects of Atopic Dermatitis

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Clinical Evaluation of Antipruritic Drugs

Cited by 10 publications

References 9 publications

Anti-Itch Treatments: Do They Work?

Anti-Itch Treatments: Do They Work?

Do Systemic Antipruritic Agents Work?

Management of AD

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