“…After intravenous administration in melanoma patients as single agent or in combination with anti PD-1 antibody, FixVac produces a clinical response rate in 12% and 35% of patients, respectively, with a good safety profile ( 14 ). Similarly, a long peptide vaccine targeting indoleamine-2,3-dioxygenase 1 (IDO)/PD-L1 (IO102/103) in combination with the anti PD-1 antibody nivolumab in a phase 1b/2 study in 30 naïve treatment advanced melanoma patients demonstrated 80% of clinical objective responses, including 43% of complete responses ( 15 ). Recently, data from a preclinical study compared in animal breast cancer models, the antitumoral effect of a personalized vaccine versus a vaccine based on the use of shared antigens showed similar antitumoral activity.…”