Clinical Effect of the Guizhi Shaoyao Zhimu Decoction in the Treatment of Hyperuricemia

Abstract

Traditional Chinese Medicine (TCM) is a medical system with a distinctive theoretical framework and extensive experience in identification and treatment acquired by the Chinese people in long-term medical practice and life practice. It is a complete, integrated, and complex knowledge system in epistemology. This study is aimed at exploring the clinical effectiveness of TCM called the Guizhi Shaoyao Zhimu Decoction in the treatment of hyperuricemia. A total of 100 patients with hyperuricemia at the Medical College of the Second Clinical College, Shandong, China, from January 2019 to January 2022 are selected as the research subjects and divided into group A and group B according to the random table method, with 50 cases in each group. Group A is treated with oral allopurinol tablets, 100 mg, 2 times a day, and group B is treated with the modified Guizhi Shaoyao Zhimu Decoction based on group A. For observation, serum uric acid (SUA) levels, urinary uric acid (UUA) levels, levels of serum inflammatory response factors (IL-6, CRP, and TNF-α), vascular endothelial function indexes (serum malondialdehyde (MDA) content, nitric oxide (NO) content), an acute attack of gout, and the incidence of adverse reactions are measured. Results show that after 2 w and 4 w of treatment, the levels of blood uric acid in each group gradually decreased compared with those before treatment, and group B is lower than group A ( P < 0.05 ). After treatment, the vascular endothelial function indexes and inflammatory factor levels in each group are significantly improved compared with those before treatment, and the indexes in group B are better than those in group A. There is no significant difference in the incidence of related adverse reactions and acute attack of gout ( P > 0.05 ). This shows that the TCM Guizhi Shaoyao Zhimu Decoction has a significant curative effect in the treatment of patients with hyperuricemia, which is worthy of clinical reference application.

Effects and Mechanisms of Traditional Chinese Medicine and Related Active Constituents Treating Gout

“…Therefore, an antiinflammatory effect is produced. Furthermore, GSZD can lower serum uric acid levels [141,142]. the positive drug [143].…”

Discussion on the Understanding of Guizhi Decoction in Treatise on Cold-Attack

“…The common deficiency syndrome in clinical practice is the deficiency cold syndrome of the middle viscera, but there is also abdominal pain of spleen yin deficiency syndrome, which cannot be ignored. Chen Ying [21] in the clinical treatment of patients with spleen yin deficiency syndrome, has a good effect. The patient had abdominal pain deficiency syndrome, but other symptoms showed that it was not Taiyin deficiency syndrome or Yangming disease.…”

Si Miao San relieves hyperuricemia by regulating intestinal flora

“…Shi Wei Ru Xiang ameliorates renal dysfunction in mice with hyperuricemia (Li et al, 2022). Similarly, Jianpishenshi (Yin et al, 2022), Jiangniaosuan (Guo et al, 2022), Gegen Qinlian decoction (Wang et al, 2021), Guizhi Shaoyao Zhimu decoction, and so forth are also recently reported as potential therapeutic drugs for hyperuricemia (Yang et al, 2022).…”