Clinical Effect of Nicorandil Combined with Aspirin in the Treatment of Myocardial Ischemia

Abstract

Objective. To investigate the clinical effect of nicorandil combined with aspirin in the treatment of myocardial ischemia. Methods. A total of 104 patients with myocardial ischemia were admitted to our hospital from June 2019 to August 2020. These patients were selected as the research objects and randomly divided into two groups: the control group and the observation group. The control group was given asilin, and the observation group was given nicorandil tablets based on the control group. Both groups were given continuous treatment for 3 months. The curative effect, cardiac function indexes, dynamic electrocardiogram, and the occurrence of adverse reactions were observed in the two groups. Results. The total effective rate of the observation group was 96.15% (50/52), which was higher than that of the control group (61.54%, 32/52), and the difference was statistically significant ( P < 0.05 ). After treatment, left ventricular ejection fraction (LVEF) and peak early/late diastolic flow velocity (E/A) were increased ( P < 0.05 ), while peak early diastolic flow velocity to peak mitral annular root movement velocity (E/Ea) was decreased ( P < 0.05 ). After treatment, LVEF and E/A in the observation group were higher than those in the control group, while E/Ea was lower than that in the control group ( P < 0.05 ). The frequency, duration of ST segment, and a total load of myocardial ischemia in the ST segment within 24 h after treatment were decreased compared with those before treatment ( P < 0.05 ). The frequency and duration of ST segment decreased, and the total load of myocardial ischemia in the observation group was lower than those in the control group within 24 h after treatment ( P < 0.05 ). After treatment, the total occurrence of adverse reactions in the observation group was lower than that in the control group ( P < 0.05 ). Conclusion. Nicorandil combined with aspirin in the treatment of patients with myocardial ischemia has a significant effect, which can effectively improve the electrocardiogram and cardiac function indicators of patients and reduce the incidence of adverse reactions and is worthy of clinical application.

Мікросудинна Стенокардія Крізь Призму Застосування Нікорандилу

“…Болюсне інтракоронарне введення нікорандилу пацієнтам з ІХС під час ЧКВ знижує активність системного запалення та оксидативного стресу, спричинену інтервенційним втручанням [14]. Комбінація нікорандилу з ацетилсаліциловою кислотою сприяє зменшенню вираженості ішемії міокарда у хворих на ІХС та супроводжується вірогідним (р<0,05) зростанням показників фракції викиду (ФВ) ЛШ, пікової швидкості раннього/пізнього діастолічного кровотоку (E/A), швидшим зниженням сегмента ST порівняно з контролем [15]. яскравим прикладом сприятливого впливу нікорандилу на коронарну мікроциркуляцію є результати нещодавно опуб лікованого багатоцентрового проспективного подвійного сліпого РКД CHANGE, в якому вивчали здатність нікорандилу впливати на розмір ІМ на тлі проведення ЧКВ [16].…”

Retracted: Clinical Effect of Nicorandil Combined with Aspirin in the Treatment of Myocardial Ischemia

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process: Discrepancies in scope Discrepancies in the description of the research reported Discrepancies between the availability of data and the research described Inappropriate citations Incoherent, meaningless and/or irrelevant content included in the article Manipulated or compromised peer review …”

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [1]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process:…”