Clinical Effect of Jumihaidokuto (Tsumura) on Eczema

Mura, TAlKlKI; Yoshiike, Takashi; Tsuboi, Ryozi; Ikeya, Tazuko; Ogawa, Hideoki; G, Zhan

doi:10.14789/pjmj.31.584

Cited by 2 publications

(1 citation statement)

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“…In Japan, JHT is approved for prescription to patients with ailments, such as acute and/or purulent skin disorders, hives, acute eczema, and athlete’s foot. Furthermore, JHT has also been reported to be useful for the clinical treatment of palmoplantar pustulosis [ 14 ], chronic eczema [ 15 ], and acne vulgaris [ 16 ]. In an in vivo study, JHT suppressed Propionibacterium acnes -induced dermatitis by modulating the functions of macrophages [ 17 ], and in in vitro studies, JHT was found to enhance neutrophil functions, such as chemotaxis and phagocytosis [ 18 ], and to inhibit the induction of neutrophil-derived and cell-free reactive oxygen species (ROS) in a dose-dependent manner [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Oral administration of Jumihaidokuto inhibits UVB-induced skin damage and prostaglandin E2 production in HR-1 hairless mice

Murata¹,

Oyama²,

Ogata³

et al. 2020

J Nat Med

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This study was conducted to investigate whether and how Jumihaidokuto (JHT), a traditional Chinese medicine, prevents UVB-induced skin damage in male HR-1 hairless mice. JHT has been traditionally prescribed for patients presenting skin disorders with redness and swelling, and, in Japan, it is approved for prescription to patients with acute and/or purulent skin disorders, hives, acute eczema, and athlete’s foot. Considering the traditional use of JHT, we hypothesized that oral administration of JHT might emerge as an effective strategy to prevent UVB-induced skin damage, such as edema and erythema. Here, we pretreated mice with JHT (1000 mg/kg, p.o.) for 3 weeks and then administered a single dose of UVB irradiation (250 mJ/cm2) on the dorsal skin. UVB irradiation increased the erythema index and transepidermal water loss (TEWL) and decreased the skin water content in the epidermis at 72 h post-irradiation. JHT treatment inhibited the increase of TEWL and the loss of water content in the epidermis, but not the elevation of the erythema index. Moreover, administration of JHT suppressed UVB-induced epidermal hyperplasia by blocking the proliferation of keratinocytes and also inhibited irradiation-triggered reduction of collagen fibers and infiltration of immune cells into the dermis. Lastly, administration of JHT suppressed UVB-induced production of proinflammatory mediators, such as prostaglandin E2 and interleukin-1β. These results suggest that JHT prevents UVB-induced skin damage and that the underlying mechanism involves the inhibition of proinflammatory mediators.

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