Clinical Durability of the Pericardial Xenograft Valve: Ten Years' Experience with Mitral Replacement

Ionescu, Marian I.; Smith, Donald R.; Hasan, Syed; Chidambaram, M; Tandon, Anand P.

doi:10.1016/s0003-4975(10)62496-4

Cited by 96 publications

(14 citation statements)

References 28 publications

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“…Bovine pericardium (BP) has been used extensively as a biomaterial in the fabrication of bioprosthetic heart valves (BHV), 3,6,9,10,11,17,25,34,37 whose function and performance depend critically on the mechanical properties of the leaflet tissue. For example, leaflet mechanical property mismatch can cause asynchronous closing of the leaflets resulting in poor functioning of the valve, which may potentially impair valve durability.…”

Section: Introductionmentioning

confidence: 99%

Optimal bovine pericardial tissue selection sites. I. Fiber architecture and tissue thickness measurements

Hiester

Sacks

1998

J. Biomed. Mater. Res.

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Use of bovine pericardium as an engineered biomaterial in the fabrication of bioprosthetic heart valves is limited, in part, by substantial intra- and intersac variations in its fibrous structure. To quantitatively assess this variability, we determined the fiber architecture of 20 whole BP sacs. Each sac was mounted on a prolate spheroidal mold, cleared and preserved in 100% glycerol, then sectioned into four equisized quadrants. This preparation method allowed for accurate intersac comparisons and minimized tissue distortions. The fiber architecture was evaluated by small-angle light scattering (SALS) using a 2.54-mm rectilinear grid resulting in approximately 1200 SALS measurements per quadrant, along with tissue thickness measured at 55 locations per quadrant. The fiber architecture was described in terms of fiber preferred directions, degree of orientation, and asymmetry of the fiber angular distribution. The BP sac fiber architecture demonstrated substantial intra- and intersac variability, with local fiber preferred directions changing by as much as 90 degrees within approximately 5 mm. Overall, most sacs revealed potential selection areas in the apex region characterized by a high degree of orientation, high uniformity in fiber preferred directions, and uniform tissue thickness. However, the size, location, and fiber orientation of these potential selection areas varied sufficiently from sac-to-sac to question whether anatomic location alone is sufficient for consistent localization of regions of high structural uniformity suitable for improved BHV design.

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Section: Introductionmentioning

confidence: 99%

Optimal bovine pericardial tissue selection sites. I. Fiber architecture and tissue thickness measurements

Hiester

Sacks

1998

J. Biomed. Mater. Res.

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“…Bovine pericardium (BP)-derived biomaterials, first introduced into clinical practice in bioprosthetic heart valves1, are now widely used234. Overcoming the aggressive recipient graft-specific rejection response is critical to utilizing such xenogeneic biomaterials in clinical practice5.…”

mentioning

confidence: 99%

Effect of bovine pericardial extracellular matrix scaffold niche on seeded human mesenchymal stem cell function

Liu

Wong

Griffiths

2016

Sci Rep

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Numerous studies have focused on generation of unfixed bovine pericardium (BP) extracellular matrix (ECM) for clinical application. However, the extent to which maintenance of native ECM niche is capable of directing behavior of repopulating cells remains relatively unexplored. By exploiting the sidedness of BP scaffolds (i.e., serous or fibrous surface), this study aims to determine the effect of ECM niche preservation on cellular repopulation using different scaffold generation methods. BP underwent either sodium dodecyl sulfate (SDS) decellularization or stepwise, solubilization-based antigen removal using amidosulfobetaine-14 (ASB-14). SDS scaffolds were toxic to repopulating human mesenchymal stem cells (hMSC). Scanning electron microscopy revealed distinct surface ultrastructure of ASB-14 scaffolds based on native BP sidedness. Basement membrane structures on the serous side stimulated hMSC cell monolayer formation, whereas fibrous side facilitated cell penetration into scaffold. Additionally, serous side seeding significantly increased hMSC adhesion and proliferation rate compared to the fibrous side. Furthermore, scaffold ECM niche stimulated sidedness dependent differential hMSC human leukocyte antigen expression, angiogenic and inflammatory cytokine secretion. This work demonstrates that ECM scaffold preparation method and preservation of BP side-based niches critically affects in vitro cell growth patterns and behavior, which has implications for use of such ECM biomaterials in clinical practice.

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“…Advantages of porcine pericardium as patch graft include its proven good performance in a critical site such as the heart (19)(20)(21) ; avoidance of the potential transmission of undetected human infectious agents, such as HIV (5)(6) , that can potentially occur with homologous materials, as well as prionic diseases (14) . Other advantages over sclera include uniform quality, easier handling, and commercial availability without dependence on an eye bank with potentially lower costs.…”

Section: Discussionmentioning

confidence: 99%

“…No cases of TSE transmission have been described to date when using porcine pericardium, although there was a recent report of TSE in a porcine dura mater recipient (17) . Porcine and bovine pericardium have been used for cardiac valve replacement for over 30 years (18)(19) with a low incidence of valve-related complications and high durability (20) . To the best of our knowledge, there is no similar study in the literature evaluating porcine pericardium as silicone tube coverage or its use in any ophthalmologic surgery.…”

Section: Introductionmentioning

confidence: 99%

Porcine pericardium as glaucoma implant tube coverage: an experimental study

Pinto¹,

Regatieri

Tavares

et al. 2008

Arq. Bras. Oftalmol.

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Clinical Durability of the Pericardial Xenograft Valve: Ten Years' Experience with Mitral Replacement

Cited by 96 publications

References 28 publications

Optimal bovine pericardial tissue selection sites. I. Fiber architecture and tissue thickness measurements

Optimal bovine pericardial tissue selection sites. I. Fiber architecture and tissue thickness measurements

Effect of bovine pericardial extracellular matrix scaffold niche on seeded human mesenchymal stem cell function

Porcine pericardium as glaucoma implant tube coverage: an experimental study

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