Clinical development of new drug–radiotherapy combinations

Sharma, Ricky A.; Plummer, Ruth; Stock, Julie; Greenhalgh, Trisha; Ataman, Özlem; Kelly, Stephen; Clay, Robert; Adams, Rachel; Baird, Richard D.; Billingham, Lucinda; Brown, Sarah; Buckland, Sean; Bulbeck, Helen; Chalmers, Anthony J.; Clack, Glen; Cranston, Aaron; Damstrup, Lars; Ferraldeschi, Roberta; Förster, Martin; Golec, J. M. C.; Hagan, R.M.; Hall, Emma; Hanauske, Axel‐R.; Harrington, Kevin; Haswell, Tom; Hawkins, M.; Illidge, Tim; Jones, Helen M.F.; Kennedy, Andrew S.; McDonald, Fiona; Melcher, Thorsten; O’Connor, James P.B.; Pollard, John R.; Saunders, Mark; Sebag‐Montefiore, David; Smitt, Melanie C.; Staffurth, John; Stratford, Ian J.; Wedge, Stephen R.

doi:10.1038/nrclinonc.2016.79

Cited by 234 publications

(176 citation statements)

References 146 publications

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“…The use of mice in studying tumour response to potential therapies has become a typical part of an oncology pipeline. Recent consensus work to promote oncologic discovery has championed the evaluation of novel drug-radiation combinations, 5 and such preclinical work will predominantly use mice in preclinical testing.…”

Section: 3mentioning

confidence: 99%

Tumour and normal tissue radiobiology in mouse models: how close are mice to mini-humans?

Koontz¹,

Verhaegen²,

Ruysscher³

2017

BJR

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Animal modelling is essential to the study of radiobiology and the advancement of clinical radiation oncology by providing preclinical data. Mouse models in particular have been highly utilized in the study of both tumour and normal tissue radiobiology because of their cost effectiveness and versatility. Technology has significantly advanced in preclinical radiation techniques to allow highly conformal image-guided irradiation of small animals in an effort to mimic human treatment capabilities. However, the biological and physical limitations of animal modelling should be recognized and considered when interpreting preclinical radiotherapy (RT) studies. Murine tumour and normal tissue radioresponse has been shown to vary from human cellular and molecular pathways. Small animal irradiation techniques utilize different anatomical boundaries and may have different physical properties than human RT. This review addresses the difference between the human condition and mouse models and discusses possible strategies for future refinement of murine models of cancer and radiation for the benefit of both basic radiobiology and clinical translation.

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Section: 3mentioning

confidence: 99%

Tumour and normal tissue radiobiology in mouse models: how close are mice to mini-humans?

Koontz¹,

Verhaegen²,

Ruysscher³

2017

BJR

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“…Flowcytometric analysis further proves the enhanced sensitizing effect of N-CTD to apoptosis in TRAIL-resistant cells. Understanding the mechanisms of combination therapy is necessary for the clinical development of small molecule-based drug delivery system combined with conventional therapy (34).…”

Section: Discussionmentioning

confidence: 99%

Sensitization to TRAIL and Radioprotective Effect of NCoumaroyl Tyramine Diacetate from Tinospora Cordifolia Induces Apoptosis and Inhibits Neoangiogenesis to Act as an Anti-Cancer Compound.

Yashaswini¹,

Salimath²

2017

IOSR JBB

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“…Drugs enhancing radiation response are an area for potential significant gains in cure rates with radical treatment, although cautious study design is essential given the risk of long-term radiation toxicity [12,13]. PATRIOT attempts to gain more meaningful toxicity data from a study treating a wide range of patients by stratifying by site of irradiation.…”

Section: Discussionmentioning

confidence: 99%

PATRIOT: A phase I study to assess the tolerability, safety and biological effects of a specific ataxia telangiectasia and Rad3-related (ATR) inhibitor (AZD6738) as a single agent and in combination with palliative radiation therapy in patients with solid tumours.

Dillon

Grove

McLellan

et al. 2016

JCO

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Clinical development of new drug–radiotherapy combinations

Cited by 234 publications

References 146 publications

Tumour and normal tissue radiobiology in mouse models: how close are mice to mini-humans?

Tumour and normal tissue radiobiology in mouse models: how close are mice to mini-humans?

Sensitization to TRAIL and Radioprotective Effect of NCoumaroyl Tyramine Diacetate from Tinospora Cordifolia Induces Apoptosis and Inhibits Neoangiogenesis to Act as an Anti-Cancer Compound.

PATRIOT: A phase I study to assess the tolerability, safety and biological effects of a specific ataxia telangiectasia and Rad3-related (ATR) inhibitor (AZD6738) as a single agent and in combination with palliative radiation therapy in patients with solid tumours.

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