Clinical, dermoscopic and histopathological features of melanocytic nevi in dystrophic epidermolysis bullosa

Abstract

We observed a high incidence of large and atypical melanocytic lesions in DEB patients. Although the exact explanation for this is still unclear, it seems that re-epithelization and the chronic inflammatory process may stimulate the proliferation of melanocytes, as well as the emergence of lesions with atypical clinical and dermoscopic features. As an unequivocal discrimination from malignant melanoma in vivo is not always possible, regular clinical follow-up and histopathological evaluation of suspicious lesions in EB patients are mandatory.

Pseudosyndactyly – an inflammatory and fibrotic wound healing disorder in recessive dystrophic epidermolysis bullosa

“…EBA lesions heal with scarring, and some EBA patients show fibrosis of the hands and fingers as well as inflammation (reviewed in ). Furthermore, EB nevi, typical melanocytic lesions in DEB patients , are also suspected to be caused by inflammation and fibrosis at blistering sites, which may potentially induce proliferation of melanocytes during wound healing .…”

An overview of the genetic basis of epidermolysis bullosa in Brazil: discovery of novel and recurrent disease‐causing variants

“…Although EB is one of the most common inherited skin disorders, with a birth prevalence of 1.9/100000 in Europe, epidemiological and genetic data in Brazil are scarce. The few published studies from Brazilian EB patients usually consist of small samples or case reports, addressing mainly clinical data and rarely include genetic analysis . Our aim was to characterize the genetic basis of EB in Brazil, estimating the prevalence of recurrent and novel EB variants, using a next‐generation sequencing (NGS)‐based multigene panel.…”

Pseudosyndaktylie – eine entzündliche und fibrotische Wundheilungsstörung bei rezessiver Epidermolysis bullosa dystrophica

“…EBA‐Läsionen heilen unter Vernarbung ab, und bei manchen Patienten treten Fibrose in Händen und Fingern sowie Entzündung auf (Übersicht in ). Darüber hinaus besteht der Verdacht, dass EB‐Nävi, typische melanozytäre Läsionen bei DEB‐Patienten , durch Entzündung und Fibrose an blasenbildenden Stellen ausgelöst werden, was möglicherweise die Proliferation von Melanozyten während der Wundheilung induziert .…”