Clinical course of autoimmune hemolytic anemia: an observational study

Oliveira, M. C.; Oliveira, Benigna Maria de; Murao, Mitiko; Vieira, Zilma M.; Gresta, Letícia Trivellato; Viana, Marcos Borato

doi:10.2223/jped.1438

Cited by 19 publications

(26 citation statements)

References 22 publications

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“…Mixed type of AIHA is rare in the pediatric age group. Review of literature revealed very few cases of mixed type of AIHA [3,[6][7][8][9].…”

Section: Discussionmentioning

confidence: 99%

“…Cause of AIHA in children remained obscure in majority of cases labelling them as idiopathic or primary [8,11]. Associated medical conditions linked to AIHA such as viral infections, SLE, Mycoplasma pneumonia, immunisation, tuberculosis, diabetes mellitus, Hodgkin's lymphoma, auto immune hepatitis, sepsis with bacterial endocarditis due to Staphylococcus aureus, Guillain-Barré syndrome and Langerhan cell histiocytosis have been reported [3, 6-9, 11, 12].…”

Section: Discussionmentioning

confidence: 99%

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Autoimmune Hemolytic Anemia: Mixed Type—A Case Report

Reddy

Samayam

Ravichander

et al. 2011

Indian J Hematol Blood Transfus

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“…Mixed type of AIHA is rare in the pediatric age group. Review of literature revealed very few cases of mixed type of AIHA [3,[6][7][8][9].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Autoimmune Hemolytic Anemia: Mixed Type—A Case Report

Reddy

Samayam

Ravichander

et al. 2011

Indian J Hematol Blood Transfus

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“…3 Corticosteroids and immunoglobulin are considered the first line treatments for AIHA in immune competent patients, while splenectomy is reserved for those cases that do not respond. 14 In patients with HIV/AIDS and AIHA care must be taken in placing them on steroids as it may further worsen their immune suppression. Research has shown that HIV/ AIDS patients with AIHA who receive red cell transfusions have an increased risk of thromboembolism which may be fatal.…”

mentioning

confidence: 99%

Autoimmune hemolytic anemia in HIV-infected patients: A hospital based study

2008

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Background:The prevalence of anemia in HIV/ AIDS patients is high, with a multitude of possible etiologies; autoimmune hemolytic anemia (AIHA) in HIV/AIDS patients has been associated with a poor prognosis when treated with red cell transfusion. Our aim was to demonstrate the frequency of AIHA in a cohort of adult Nigerian HIV/AIDS patients and to see if the presence or not of AIHA is related to the severity of the disease with regards to the CD4 counts and the presence or absence of opportunistic infections. Method: Ninety-eight adult patients with HIV infection were screened for the presence of AIHA using the packed cell volume (PCV), direct antiglobulin test (DAT) and reticulocyte count (RC). Results: The frequency of AIHA was 3.06%, 36.74% of our study population were anemic; 11.22% had a positive DAT. Mean RC was 2.22 +/ 0.90 for all the patients. There was no statistically significant difference in the PCV of patients that had positive and negative DAT. There was no correlation between the presence of AIHA, use of ART, presence of opportunistic infections or CD4 counts. Conclusion:We conclude that in spite of the low frequency of AIHA in HIV/AIDS patients, the fact that most patients will respond to standard treatment makes it imperative to screen HIV/AIDS patients with anemia for the presence of AIHA. Again since HIV/AIDS patients with AIHA may have a fatal reaction to red cell transfusion, we suggest that anemic patients with HIV/AIDS in non-emergency situations be screened for the presence of AIHA before receiving red cell transfusions when indicated. Key words: Autoimmune, anemia, hemolysis, HIV/AIDS RésuméCulture générale: Il y a trop de fréquence d'anémie parmi les malades sero-positifs ou les malades atteints de sida, souvent accompagne d'un grand nombres d'aetiologies: anémie haemolylique autoimmuno (AHAI) parmi les malades sero-positifs est directement lie a une mauvaise pronostic, surtout quand on fait le traitement avec une transformation du globule rouge. Notre objectif est de démontrer la fréquence de (AHAI) parmi un nombre d'adultes nigérians sero-positifs ou qui sont atteints du sida. C'est aussi de vérifier si la présence ou l'absence de (AHAI) est lie directement lie a la gravite de la maladie, de la maladie surtout quand il s'agit de la numération CD4 et de la présence ou absence des infections opportunistic. Modalité: À l'aide de l'analyse directe antiglobulin (ADA) et la numération réticulocyte (NR) et le packed cell volume (PCV) ; quatre-vingt-dix-huit malades sero-positifs, ont passé un test de dépistage pour vérifier la présence de (AHAI) Résultat: La fréquence de (AHAI) était 3.06%, 36.74% de notre population était anémique ; 11.22% était positif de l'analyse antiglobulin.Pour la numération reticulocy, la moyenne était 2.22+\-0.90 pour tous les malades, on n'a trouvé aucune différence qui est statistiquement significatif parmi les malades Autoimmune haemolytic anemia in HIV patients. Olayemi E. et al.Page | 73 positif de (ADA) et négatif de (ADA). Il n y avait aucun rappor...

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“…C in cold type of AIHA 2 .Autoimmune hemolytic anemia is known to be associated with infection, malignancy or other autoimmune diseases but in most cases it is idiopathic 1, 2 . Cause of AIHA in children remained obscure in majority of cases labeling them as idiopathic or primary 8,11 . Many medical conditions are associated with AIHAsuch as viral infections, SLE, Mycoplasma pneumonia, immunization, tuberculosis, diabetes mellitus, Hodgkin's lymphoma, auto immune hepatitis, sepsis with bacterial endocarditis due to Staphylococcus aureus, GuillainBarre´ syndrome and Langerhan cell histiocytosis have been reported 3, 6-9, 11, 12 .…”

Section: Discussionmentioning

confidence: 99%