Clinical course of atopic dermatitis in Japanese patients

Induction of atopic eczema/dermatitis syndrome-like skin lesions by repeated topical application of a crude extract of Dermatophagoides pteronyssinus in NC/Nga mice

“…Both genetic and environmental factors are involved in the occurrence of this disease [2]. The prevalence of AEDS is increasing especially in industrialized countries because of frequent exposure to harmful environmental pollutants from industry [3,4]. Although AEDS is a severe health problem in developed countries, its pathogenesis is not clearly understood.…”

Establishment of an atopic dermatitis‐like skin model in a hairless mouse by repeated elicitation of contact hypersensitivity that enables to conduct functional analyses of the stratum corneum with various non‐invasive biophysical instruments

“…A topic dermatitis (AD) is a chronic relapsing skin disease characterized by eczematous skin lesions typically distributed at the predilection sites with lichenification, pruritic excoriations, and susceptibility to cutaneous infections associated with pruritic dry skin changes observable even in non‐lesional skin (1–3). In recent years, the number of AD patients has greatly increased in Japan as well as in other industrialized countries (4–7). To investigate the mechanisms of AD pathogenesis, different mouse models have been developed, e.g., Balb/C mouse repeatedly treated with 2,4,6‐trinitro‐1‐chrolobenzene (TNCB) (8, 9) and the NC/Nga mouse (10, 11).…”