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Cited by 4 publications
(6 citation statements)
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“…The outcome of lymphoma-associated HLH is suboptimal. A multicenter retrospective study by Li et al [ 12 ] demonstrated that the median OS time of patients with lymphoma-associated HLH was only 1.5 months. The catastrophic nature of the disease is one of the potential reasons for this dismal outcome.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The outcome of lymphoma-associated HLH is suboptimal. A multicenter retrospective study by Li et al [ 12 ] demonstrated that the median OS time of patients with lymphoma-associated HLH was only 1.5 months. The catastrophic nature of the disease is one of the potential reasons for this dismal outcome.…”
Section: Discussionmentioning
confidence: 99%
“…This comparison might not be entirely fair because controlling the underlying disease is still the cornerstone of lymphoma-associated HLH treatment. Li et al [ 12 ] reported that lymphoma-associated HLH patients who received etoposide and anthracycline had a better OS than patients who did not, suggesting that more intensified regimens containing chemotherapeutic agents effective against lymphoma are crucial to lymphoma-associated HLH. However, not every patient in our study cohort received more intensive frontline treatments than CHOP (cyclophosphamide, adriamycin, vincristine, and prednisolone) or CHOP-like regimens.…”
Section: Discussionmentioning
confidence: 99%
“…Each possible etiology has distinct clinical characteristics and prognosis. Even in lymphomaassociated HLH that has the worst prognosis, the treatment response is diverse (34). HLH could occur in EBV-associated T-/NK-cell lymphoproliferative disorders, which is a spectrum of disease from infection to malignancy.…”
Section: Timely Diagnosis and Prognosis Are Critical For Hlh Considering That The Early And Proper Administration Of An Efficaciousmentioning
confidence: 99%
“…On the other hand, the heterogeneous distribution of metabolism or density may also suggest the involvement of tumor cells (41)(42)(43). Both the malignancy and EBV infection seemed to link an inferior prognosis in adult HLH (9,34,44,45). Additionally, the radiomic features have the possibilities associated with genetic signatures (3,46); however, the underlying biological significance of these radiomic features has not been fully studied and the relationships among radiomic features, genetic signatures, and prognosis need further exploration in HLH.…”
Section: Timely Diagnosis and Prognosis Are Critical For Hlh Considering That The Early And Proper Administration Of An Efficaciousmentioning
confidence: 99%
“…Therefore, it is highly favorable to perform an alternative/additional analysis taking (baseline) confounders into account. In this regard, it would be of particular interest to sub-analyze groups by HLH trigger, since our data suggests that etoposide might be especially beneficial in EBV and lymphoma associated HLH (Table 1 ) [ 4 , 6 , 7 ]. Owing to the lack of data, we were unable to perform such analysis.…”
mentioning
confidence: 99%