Clinical characteristics of cerebral venous sinus thrombosis

Wang, Jiawei; Li, Jinping; Song, Ying-Lun; Tan, Ke; Wang, Yu; Li, Tao; Guo, Ping; Xiong, Li; Wang, Yan; Zhao, Qi-Huang

doi:10.17712/nsj.2015.3.20140625

Cited by 28 publications

(30 citation statements)

References 12 publications

(20 reference statements)

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“…The main causes of non-infectious CVST formation are heart disease, puerperium, blood diseases and long-term oral contraceptives. According to the onset time, it can be divided into acute, subacute and chronic processes, with high disability rate and mortality [14,15]. This case was a young female patient, consistent with the common age of venous sinus thrombosis.…”

Section: Discussionsupporting

confidence: 53%

Clinical Features of Diffuse Leptomeningeal Glioneuronal Tumor With the First Symptom of Headache and Decreased Vision Misdiagnosed as Venous Sinus Thrombosis

Bao

Ding

et al. 2019

J Neurol Res

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Meningeal carcinoma has a variety of clinical manifestations and a high mortality and disability rate. Among them, cranial hypertension is one of the important causes of death, which is easy to be missed or misdiagnosed. The purpose of this case report is to describe the clinical features of diffuse leptomeningeal glioneuronal tumor (DNGNT) with the first symptom of headache accompanied by decreased vision misdiagnosed as venous sinus thrombosis. The patient initially suffered from headache and decreased vision, and rapidly developed blindness. According to the clinical manifestations and cerebrospinal fluid (CSF) examination results, the patient was initially misdiagnosed as venous sinus thrombosis, the intracranial pressure was relieved by Ommaya capsule, and the cerebrovascular condition was observed by magnetic resonance venogram (MRV) and digital subtraction angiography (DSA). The degree of meningeal enhancement was observed by enhanced magnetic resonance imaging (MRI), and meningeal cancer cells were found by CSF cytology. The patient was excluded from viral meningitis, tuberculous meningitis, cryptococcal meningitis, optic neuromyelitis, and central nervous system Behcet's disease by routine examination. Ommaya capsule implantation relieved the intracranial hypertension, and vision was restored after treatment. No venous sinus thrombosis was found in MRV and DSA; brain-enhanced MRI revealed extensive linear enhancement of the meninges, and CSF cytology revealed grotesque, actively dividing tumor cells; she was diagnosed as DLGNT. Meningeal carcinoma cannot be excluded in adolescents without tumor history. When patient has unexplained intracranial hypertension, it is necessary to consider DLGNT; early brain-enhanced MRI and CSF cytology are helpful for early diagnosis. For cranial hypertension, timely placement of Ommaya capsule can improve patient quality of life and save vision in time; molecular targeted therapy as early as possible can prolong survival.

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Section: Discussionsupporting

confidence: 53%

Clinical Features of Diffuse Leptomeningeal Glioneuronal Tumor With the First Symptom of Headache and Decreased Vision Misdiagnosed as Venous Sinus Thrombosis

Bao

Ding

et al. 2019

J Neurol Res

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“…The incidence rate of ASS has a widely varied range in different studies. ASS in CVST are reported in 6.9–76% of patients, with the higher incidence in severe CVST cases (60%) and peripartum CVST (76%) . The risk of PCE is low compared with the high rate of ASS, and is reported in about 4–16% of patients in different studies that followed patients between 12 months to a mean of 77.8 months .…”

Section: Discussionmentioning

confidence: 99%

Seizure in cerebral venous and sinus thrombosis

2018

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SummaryMany conflicting issues exist about seizure in the setting of cerebral venous and sinus thrombosis (CVST). In this article we aimed to address the existing data regarding incidence, characteristics, predictors, treatment, and prognosis of acute and late seizures in patients with CVST and to prepare more practical information for clinicians. PubMed, Embase, Web of science and Cochrane databases were searched within 1966–2016 using relevant keywords. A total of 63 papers met the inclusion criteria. Seizures are classified as acute symptomatic seizures (ASS; first 14 days) and post‐CVST epilepsy (PCE; after 14 days). The incidence had been reported in a wide range of 6.9–76% for ASS and 4–16% for PCE. Focal and generalized seizures were observed with different predominance. ASS commonly occurred in patients with loss of consciousness, focal neurological deficits, supratentorial lesions and thrombosis in superior sagittal sinus, straight sinus, and cortical veins. PCE had been predisposed by occurrence of ASS, motor deficit, and supratentorial lesions, particularly hemorrhage. Most experts believe that primary prophylaxis with antiepileptic drugs in the acute phase is not indicated. However, the initiation of prophylaxis after the first seizure in patients with supratentorial lesions or focal neurological deficit should be recommended. The quality of current evidence is low and most conclusions are based on expert opinions. More accurate reports of seizure semiology, detailed antiepileptic treatment plans, and outcomes are necessary to answer the existing questions.

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“…It could be the only symptom or the front runner of other symptoms (20,21). Headache is caused by an increase in intracranial pressure due to impairment of venous drainage (22) and it was the most frequent symptom with a rate of 64.5% in our study. Visual disturbance was the most accompanying symptom in our study and it was thought to be related with increased intracranial pressure because the patients with headache also had papilledema.…”

Section: Discussionmentioning

confidence: 47%

Clinical Features of Cerebral Venous Sinus Thrombosis

Eryıldız¹,

Özdemi̇r²

2017

tnd

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Amaç: Serebral venöz sinüs trombozunun (SVST) altında yatan nedenleri, hastalığın karşımıza çıkış şekillerini, görüntüleme özelliklerini, tedavi tiplerini ve hastaların akıbetlerini araştırmayı amaçladık. Gereç ve Yöntem:Eskişehir Osmangazi Üniversitesi Tıp Fakültesi, Nöroloji Anabilim Dalı, Nöroloji İnme Merkezi'nde Nisan 2011-Eylül 2016 tarihleri arasında SVST tanısı ile takip ettiğimiz hastaların demografik verileri, başvuru belirti ve bulguları, nörogörüntüleme ve laboratuvar incelemeleri, hastalığın altında yatan nedenleri, tedavi şekillerimiz ve yine hastaların hastaneden çıkarıldıkları sıradaki nörolojik fonksiyonları geriye dönük olarak incelendi. Bulgular: SVST tanılı 25'i kadın toplam 31 hasta çalışmaya dahil edildi. Hastaların yaş ortalaması 43,7 idi (standart sapma: 16,4 değişim aralığı: 22-78). En sık görülen belirti baş ağrısı olup, en sık altta yatan nedenler gebelik ve lohusalık, en sık tutulan sinüs ise transvers sinüs idi. Hastaların büyük kısmının (29/31, %93,6) antikoagüle edildiği ve taburcu edildikleri sıradaki Modifiye Rankin Skala skorlarının 2 ya da altında olduğu görüldü.Sonuç: Bu çalışmada inme merkezimizde takip ettiğimiz SVST tanılı hastaların özelliklerini inceledik ve hastaların akıbetlerinin önceden sanılanın aksine iyi olduğunu gösterdik. Ancak, tedavi şekilleri ve hastalığın akıbeti ile ilgili daha kesin sonuçlara ulaşabilmek için daha geniş kohortlu ileriye dönük çalışmalara ihtiyaç vardır.Anahtar Kelimeler: Venöz tromboz, sinüs trombozu, inme, inme alt tipi Objective: To investigate the predisposing factors for cerebral venous sinus thrombosis (CVST), presenting patterns of the disease, imaging characteristics, types of treatment, and outcomes of patients. Materials and Methods:Retrospectively, between April 2011 and September 2016 at Eskisehir Osmangazi Stroke Center, the demographic data, symptoms and findings, neuroimaging and laboratory findings of patients with CVST were collected. Additionally, predisposing factors for the disease, treatment strategies, and the neurologic functions of patients at discharge were examined. Results:Thirty-one patients with CVST were included in the study, 25 of whom were female. The mean age of the patients was 43.7 years (standard deviation: 16.4; range, 22-78 years). The most common symptom was headache and the most common predisposing factors were pregnancy and puerperium. Also, transverse sinus was the most common thrombosed sinus. In the majority of patients (29/31, 93.6%), anticoagulation was applied and the Modified Rankin Scale score was 2 or below. Conclusion:In this study, we detailed the characteristics of patients with CVST at our stroke center and contrary to previous knowledge, we showed that the outcomes of patients were good. However, to achieve more accurate conclusions about treatment strategies and outcomes, we need prospective studies with larger cohorts.

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Clinical characteristics of cerebral venous sinus thrombosis

Cited by 28 publications

References 12 publications

Clinical Features of Diffuse Leptomeningeal Glioneuronal Tumor With the First Symptom of Headache and Decreased Vision Misdiagnosed as Venous Sinus Thrombosis

Clinical Features of Diffuse Leptomeningeal Glioneuronal Tumor With the First Symptom of Headache and Decreased Vision Misdiagnosed as Venous Sinus Thrombosis

Seizure in cerebral venous and sinus thrombosis

Clinical Features of Cerebral Venous Sinus Thrombosis

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