Clinical Characteristics, Management, and Functional Outcomes in Chinese Patients Within the First Year After Intracerebral Hemorrhage: Analysis from China National Stroke Registry

Wang, Wen‐Juan; Lu, Jingjing; Wang, Yongjun; Wang, Chunxue; Wang, Yilong; Hoff, Kolin; Yang, Zhi‐gang; Liu, Liping; Wang, An-Xin; Wang, Wenjuan

doi:10.1111/j.1755-5949.2012.00367.x

Cited by 45 publications

(55 citation statements)

References 38 publications

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“…13 Patients were excluded if they met any following criteria: history of seizures, primary intraventricular hemorrhage or prestroke modified Rankin Scale (mRS) of more than 2, neoplastic cause of ICH, unavailable data of ICH hematoma volume, disagreement to participate in the study, or loss to follow-up. 14 …”

Section: Methodsmentioning

confidence: 97%

Association between Seizures and Outcomes among Intracerebral Hemorrhage Patients: The China National Stroke Registry

Zhao

Wang

et al. 2015

Journal of Stroke and Cerebrovascular Diseases

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Section: Methodsmentioning

confidence: 97%

Association between Seizures and Outcomes among Intracerebral Hemorrhage Patients: The China National Stroke Registry

Zhao

Wang

et al. 2015

Journal of Stroke and Cerebrovascular Diseases

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“…The definitions of the main vascular risk factors were reported in a detailed manner in a prior study [12]. The clinical condition on admission was evaluated using the Hunt and Hess grade and the World Federation of Neurosurgical Societies (WFNS) grade [13, 14].…”

Section: Methodsmentioning

confidence: 99%

Risk Factors and Clinical Impact of Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage: Analysis from the China National Stroke Registry

et al. 2018

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Background: Delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH) is a significant cause of morbidity and mortality. While it is important to detect early signs of DCI, patients with high risk of DCI are difficult to identify, and the potential risk factors are uncertain. This study aimed to identify independent risk factors of DCI and clarify their clinical impact on outcome and the disease course. Methods: For this nationwide, multicenter, prospective clinical study involving consecutive patients with aSAH recruited from the China National Stroke Registry, demographic, clinical, radiological, and laboratorial data during hospitalisation, in-hospital complications, functional outcomes, and mortality at 3, 6, and 12 months were recorded. Using univariate and multivariate logistic regression to determine risk factors associated with the development of DCI, the contribution of DCI to short- and long-term outcomes was evaluated. Results: Of all 504 patients with aSAH, 155 developed DCI. Multivariate analysis revealed that being female, a history of diabetes mellitus, a Hunt and Hess grade of 4–5, and a World Federation of Neurosurgical Societies grade of IV–V were independent risk factors of DCI. DCI was associated with high in-hospital complications, and with a high utilization rate of supporting interventions. DCI also contributed to poorer functional outcome and higher mortality at discharge and after 3, 6, and 12 months. Conclusions: Female sex, a history of diabetes mellitus, and poor clinical grade are independent early risk factors for the development of DCI and can contribute to a better identification of patients at a high risk for DCI. DCI was associated with severe clinical course, poor outcome, and mortality both in the short- and long-term in patients with aSAH in China.

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“…[4][5][6] Moreover, most of the available data are from retrospective stroke registries [6][7][8][9][10][11][12] or from studies published more than a decade ago. 13,14 The most recent published series comes from Asian countries, 15,16 and probably have some bias and racial/ethnic specificity. Finally, it is not clear whether these series are exhaustive, taking into account, for instance, early deaths (i.e., during the first hours at the emergency room).…”

Section: Introductionmentioning

confidence: 99%

Sex-related differences in primary intracerebral hemorrhage

et al. 2016

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Objective: Little information is available about sex-related differences in intracerebral hemorrhage (ICH). This is a prospective observational study to describe the sex differences in demographics, vascular risk factors, stroke care, and outcomes in primary ICH.Methods: BasicMar is a hospital-based registry of all stroke patients admitted to a single public hospital that covers a population of 330,000. From 2005 to 2015, there were 515 consecutive acute primary ICH patients. Outcome data were obtained at 3 months.Results: More men than women had ICH (52.4% vs 47.6%); the women were older and had worse previous functional status than men, who were more likely to drink alcohol and smoke and to have ischemic heart disease and peripheral arterial disease. There were no sex differences in etiology, severity, or hemorrhage volume. ICH score was greater in women than in men (p 5 0.018). Women had more lobar ICH than men (odds ratio adjusted by age was 1.75 [95% confidence interval 1.18-2.58], p 5 0.005). The quality of stroke care was similar in both sexes. Mortality at 3 months was 44.1% in women and 41.1% in men (p 5 0.656), and 3-month poor outcome among survivors (modified Rankin Scale [mRS] score 3-5) 58.4% in women and 45.3% in men (p 5 0.027). After adjustment for previous mRS and ICH score, there were no differences in 3-month mortality or poor outcome at 3 months between sexes.Conclusions: Patients with ICH showed sex-related differences in demographic characteristics, ICH location, and vascular risk factors, but not in stroke care, 3-month mortality, or adjusted poor outcome. Neurology ® 2016;87:257-262 GLOSSARY CAA 5 cerebral amyloid angiopathy; CI 5 confidence interval; GCS 5 Glasgow Coma Scale; ICH 5 intracerebral hemorrhage; IQR 5 interquartile range; mRS 5 modified Rankin Scale; NIHSS 5 NIH Stroke Scale; OR 5 odds ratio.Intracerebral hemorrhage (ICH) is the most severe stroke subtype, with about 50% mortality within the first month after the event and only about 20%-25% of survivors able to live independently at 6 months.1-4 Sex differences in ICH characteristics and outcome have not been fully studied and the reported results have been inconclusive. A meta-analysis in 2010 4 and a review published in 2015 5 both emphasize the conflicting results reported about sex differences in ICH outcomes. Both studies concluded that more data on functional outcome after ICH are needed. Some methodologic problems that would account for the inconsistencies and heterogeneity of the available data have been noted, such as differences in metrics used, length of study period, race/ethnicity of participants, etiology, or the adjustments made in the statistical analysis. [4][5][6] Moreover, most of the available data are from retrospective stroke registries [6][7][8][9][10][11][12] or from studies published more than a decade ago. 13,14 The most recent published series comes from Asian countries, 15,16 and probably have some bias and racial/ethnic specificity. Finally, it is not clear whether these series are exhau...

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Clinical Characteristics, Management, and Functional Outcomes in Chinese Patients Within the First Year After Intracerebral Hemorrhage: Analysis from China National Stroke Registry

Abstract: This is the first report of long-term functional outcomes in ICH patients from mainland China. Our study elucidates the risk factors that may influence functional outcomes post-ICH and therefore facilitate the development of management strategies to improve ICH care in China.

Cited by 45 publications

References 38 publications

Association between Seizures and Outcomes among Intracerebral Hemorrhage Patients: The China National Stroke Registry

Association between Seizures and Outcomes among Intracerebral Hemorrhage Patients: The China National Stroke Registry

Risk Factors and Clinical Impact of Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage: Analysis from the China National Stroke Registry

Sex-related differences in primary intracerebral hemorrhage

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