Clinical characteristics and prognostic factors of brain central neurocytoma

Abstract

Background & AimsThis study is designed for the clinical characteristics and prognostic factors of central neurocytoma (CN).MethodsCN patients from 2004 to 2012 were enrolled from the Surveillance Epidemiology and End Results (SEER) data. Clinical characteristics including age, sex, race, tumor size, tumor number, surgery, and radiation therapy were summarized. Univariate and multivariate analysis were performed to explore the prognostic factors of CN.ResultsCN tended to be borderline malignant and single lesion. Compared with other brain tumor (NCN), Patients with CN (CNs) were more likely to be female, young, and non-white race. Surgery was the primary treatment of CN. Univariate and Multivariate analysis indicated tumor number and surgery were both independent prognostic factors of CN (P < 0.05). Unifocal CNs had a lower mortality risk than multifocal ones (HR 0.167, 95% CI 0.052-0.537), surgery significantly reduced the death risk of CNs (HR 0.284, 95% CI 0.088-0.921).ConclusionsCN tend to be borderline malignant, single lesion, operated on. Most CNs are female and younger. single lesion and surgery are the independent positive prognostic factors of CN.

Transcortical approach to lateral ventricular central neurocytomas: a case series and review of the literature

“…Central neurocytoma is a tumor of the young adults as observed in the results of the current study (mean age 24.75 years) and supported by the literature [4,5,8,9,11].…”

“…The affection of such a young age group makes safe radical resection of that relatively benign tumor a common demand and a surgical gold standard that can help avoid radiation therapy [5,8,9,17,18]. However, postoperative radiation therapy and/or chemotherapy may be recommended for atypical neurocytomas and for recurrent cases and was not needed in our cohort [11].…”

“…CNs were first described by Hassoun et al in 1982 [2]. They are generally slow-growing well-delineated WHO Grade II neuroepithelial intraventricular tumors that account for around 0.25 to 0.5% of all primary brain tumors and affect young adults (between 20 and 40 years) predominantly [3][4][5][6][7][8][9][10]. There have been less than 500 cases reported in the literature since its first description [11].…”

Central Neurocytoma with Hemorrhagic Presentation Case Report and Review of the Literature

“…Most of the reports demonstrated no gender predilection [ 13 , 14 ]. However, some studies showed slight male predominance [ 9 , 10 ] with one retrospective study showed female predominance [ 11 ].…”

“…CN is typically deeply seated in midline structures, most commonly in the frontal horn of the lateral ventricle adjacent to foramen of Monro and attached to septum pellucidum which might extend to the third ventricle [ 11 , 13 , 15 ]. Nevertheless, there were some cases which reported other locations of neurocytoma, such as isolated neurocytoma in the fourth and third ventricles [ 14 , 16 ], and extraventricular neurocytoma in spinal cord and brain parenchyma [ 11 , 13 , 14 ]. CN tends to be benign tumor though malignant variants were reported [ 7 , 14 ].…”