Clinical Characteristics and Outcome of Left Ventricular Ballooning Syndrome in a European Population

Previtali, Mario; Repetto, Alessandra; Camporotondo, Rita; Citro, Rodolfo; Faggiano, Pompilio; Bovelli, Daniella; Baldini, Enrico; Pasquetto, Giampaolo; Ascione, Luigi; Vignali, Luigi; Rosso, R.; Baralis, Giorgio; Rossi, Marco; Ferlini, Marco; Bossone, Eduardo; Panciroli, C; Rovere, Francesco Della; Visconti, Luigi Oltrona; Klersy, Catherine

doi:10.1016/j.amjcard.2010.08.055

Cited by 41 publications

(21 citation statements)

References 19 publications

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“…Thus the presence of an emotional or physical trigger did not identify a subgroup of patients at greater risk of acute complications and long-term recurrence. This finding is consistent with a prior European report [17] and suggests that there is a common underlying pathophysiology, regardless of the precipitating cause. Chest pain and dyspnoea were the two common presenting symptoms in our study, which were also noted in other series [18][19][20].…”

Section: Discussionsupporting

confidence: 93%

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Clinical Characteristics and Outcome of Apical Ballooning Syndrome in Auckland, New Zealand

Looi

Wong

Khan

et al. 2012

Heart, Lung and Circulation

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Section: Discussionsupporting

confidence: 93%

“…Ninety-five percent of the cohort were women over 60 years of age, similar to that reported for Japanese [5,11,12], North American [13][14][15][16], and European cohorts [17]. The distribution of patients by ethnicity was representative of the Auckland population without a predominance of a particular ethnic group.…”

Section: Discussionsupporting

confidence: 64%

Clinical Characteristics and Outcome of Apical Ballooning Syndrome in Auckland, New Zealand

Looi

Wong

Khan

et al. 2012

Heart, Lung and Circulation

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“…17 Thus the presence of an emotional or physical trigger did not identify a subgroup of patients at greater risk of acute complications and long-term recurrence. This finding is consistent with a prior European report 10 and suggests that there is a common underlying pathophysiology, regardless of the precipitating cause. Templin et al 18 recently compared 1750 patients from the Takotsubo International Registry with TC with matched controls who had an ACS.…”

Section: Clinical Presentationsupporting

confidence: 83%

“…2,3 The condition tends to occur in postmenopausal women after a stressful event. [7][8][9][10] In a systematic review, women accounted for 82% to 100% of patients with an average age of 62 to 75 years, although cases have been reported in individuals aged 10 to 91 years. …”

Section: Clinical Features Patient Characteristicsmentioning

confidence: 99%

Clinical Characteristics and Outcomes of Takotsubo Cardiomyopathy

Looi¹,

Kerr²

2016

ICFJ

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Takotsubo cardiomyopathy (TC) is a transient, reversible form of cardiomyopathy which predominantly affects post-menopausal women and is an important differential diagnosis of acute coronary syndrome. It is characterised by normal (or near-normal) coronary arteries, regional wall motion abnormalities that extend beyond a single coronary vascular bed, and often proceeded by a stressful event. The pathophysiologic mechanism is complex and remains to be elucidated. There is increasing awareness among physicians about TC and hence, more cases are being reported. The diagnosis of TC has important clinical implications in the management at presentation and afterward. In this review, we discuss the demographics, clinical features, prognosis and management of this cardiomyopathy.

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“…However, patients are at risk for recurrence even years after the first event, and data on in-hospital and longterm outcomes are limited. [7][8][9][10] The potential role of catecholamine excess in the pathogenesis of takotsubo cardiomyopathy has been long debated, 11 and as such beta-blockers have been proposed as a therapeutic strategy. 12 Nevertheless, to our knowledge, no prospective trials evaluating the therapeutic management have been reported to date.…”

mentioning

confidence: 99%

Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy

Templin¹,

et al. 2015

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BACKGROUND The natural history, management, and outcome of takotsubo (stress) cardiomyopathy are incompletely understood. METHODS The International Takotsubo Registry, a consortium of 26 centers in Europe and the United States, was established to investigate clinical features, prognostic predictors, and outcome of takotsubo cardiomyopathy. Patients were compared with age-and sex-matched patients who had an acute coronary syndrome. RESULTS Of 1750 patients with takotsubo cardiomyopathy, 89.8% were women (mean age, 66.8 years). Emotional triggers were not as common as physical triggers (27.7% vs. 36.0%), and 28.5% of patients had no evident trigger. Among patients with takotsubo cardiomyopathy, as compared with an acute coronary syndrome, rates of neurologic or psychiatric disorders were higher (55.8% vs. 25.7%) and the mean left ventricular ejection fraction was markedly lower (40.7±11.2% vs. 51.5±12.3%) (P<0.001 for both comparisons). Rates of severe in-hospital complications including shock and death were similar in the two groups (P=0.93). Physical triggers, acute neurologic or psychiatric diseases, high troponin levels, and a low ejection fraction on admission were independent predictors for in-hospital complications. During long-term follow-up, the rate of major adverse cardiac and cerebrovascular events was 9.9% per patient-year, and the rate of death was 5.6% per patient-year. CONCLUSIONS Patients with takotsubo cardiomyopathy had a higher prevalence of neurologic or psychiatric disorders than did those with an acute coronary syndrome. This condition represents an acute heart failure syndrome with substantial morbidity and mortality. (Funded by the Mach-Gaensslen Foundation and others; ClinicalTrials.gov number, NCT01947621.).

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Clinical Characteristics and Outcome of Left Ventricular Ballooning Syndrome in a European Population

Cited by 41 publications

References 19 publications

Clinical Characteristics and Outcome of Apical Ballooning Syndrome in Auckland, New Zealand

Clinical Characteristics and Outcome of Apical Ballooning Syndrome in Auckland, New Zealand

Clinical Characteristics and Outcomes of Takotsubo Cardiomyopathy

Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy

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