1999
DOI: 10.1001/archderm.135.1.26
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Clinical Characteristics and Long-term Outcome of Patients With Generalized Patch and/or Plaque (T2) Mycosis Fungoides

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Cited by 146 publications
(105 citation statements)
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“…However, in a subgroup of patients diagnosed with early MF, the disease follows a more aggressive and occasionally fatal clinical course. 4,5 Sézary syndrome (SS) is a less frequent but very aggressive form of CTCL characterized by erythroderma, generalized lymphadenopathy, and the presence of neoplastic T cells (Sézary cells) in the peripheral blood. 1 Interleukin (IL)-17A and IL-17F are 2 highly homologous proinflammatory cytokines that are produced by the Th17 subset of CD4 1 T cells.…”
Section: Introductionmentioning
confidence: 99%
“…However, in a subgroup of patients diagnosed with early MF, the disease follows a more aggressive and occasionally fatal clinical course. 4,5 Sézary syndrome (SS) is a less frequent but very aggressive form of CTCL characterized by erythroderma, generalized lymphadenopathy, and the presence of neoplastic T cells (Sézary cells) in the peripheral blood. 1 Interleukin (IL)-17A and IL-17F are 2 highly homologous proinflammatory cytokines that are produced by the Th17 subset of CD4 1 T cells.…”
Section: Introductionmentioning
confidence: 99%
“…Many patients remain at the same stage for prolonged periods; however, some progress from patch/plaque to skin tumors. 2,3 Large cell transformation associated with marked worsening of prognosis can also occur.…”
Section: Introductionmentioning
confidence: 99%
“…Although early (patch stage) mycosis fungoides often follows an indolent course, approximately one quarter of patients with generalized disease progress to a more advanced clinical stage, and Ն20% of these patients eventually die of the disease (7,8). Mycosis fungoides may also undergo transformation to cutaneous large T-cell lymphoma or present in a leukemic form termed Sezary syndrome, both of which have a grave prognosis (5,7).…”
mentioning
confidence: 99%
“…Mycosis fungoides may also undergo transformation to cutaneous large T-cell lymphoma or present in a leukemic form termed Sezary syndrome, both of which have a grave prognosis (5,7). Because a significant proportion of patients with mycosis fungoides undergo clinical progression associated with a high mortality, it may be important to initiate treatment early in the course of the disease.…”
mentioning
confidence: 99%