Clinical, behavioral, and neural measures of reward processing correlate with escitalopram response in depression: a Canadian Biomarker Integration Network in Depression (CAN-BIND-1) Report

Dunlop, Katharine; Rizvi, Sakina J.; Kennedy, Sidney H.; Hassel, Stefanie; Strother, Stephen C.; Harris, Jacqueline; Zamyadi, Mojdeh; Arnott, Stephen R.; Davis, Andrew D.; Mansouri, Farrokh; Schulze, Laura; Ceniti, Amanda K.; Lam, Raymond W.; Milev, Roumen; Rotzinger, Susan; Foster, Jane A.; Frey, Benício N.; Parikh, Sagar V.; Soares, Cláudio N.; Uher, Rudolf; Turecki, Gustavo; MacQueen, Glenda; Downar, Jonathan

doi:10.1038/s41386-020-0688-x

Cited by 31 publications

(14 citation statements)

References 52 publications

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“…1 and 2, both miR-27b-3p, miR-320b have multiple targets that can have modulatory effects on brain function. This is consistent with ndings from case-control studies in anxiety or depression showing evidence for an increase in miRs including miR-27b-3 59 and miR-320b 34 , which has been more closely related to metabolic dysfunction 19,20 . For example, global upregulation of miR-320 has been associated with impaired gluconeogenesis, lipid metabolism, and relatively higher expression of in ammation markers 60 .…”

Section: Discussionsupporting

confidence: 91%

Neuronally-Enriched Exosomal miR-27b Reveals Mechanism for Ibuprofen-Induced Acute Effects on Reward-Related Brain Processing in a Randomized, Placebo-Controlled, Double-Blind Trial

Burrows

Figueroa-Hall

Kuplicki

et al. 2021

Preprint

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This double-blind, randomized, repeated measures study evaluated whether acute administration of an anti-inflammatory drug modulates neuron-specific, inflammation-modulating microRNAs linked to macroscopic changes in reward processing. Twenty healthy subjects (10 females,10 males) completed a monetary incentive delay (MID) task and provided blood samples after administration of placebo, 200 mg, or 600 mg of ibuprofen. Neuronally-enriched exosomal microRNAs were extracted from plasma and sequenced. Results showed that: (1) 600 mg of ibuprofen exhibited higher miR-27b-3p, miR-320b, miR-23b and miR-203a-3p expression than placebo; (2) higher mir-27b-3p was associated with lower insula activation during MID loss anticipation; and (3) there was an inverse relationship between miR-27b-3p and MID gain anticipation in bilateral putamen during placebo, a pattern attenuated by both 200 mg and 600 mg of ibuprofen. Our findings indicate that miR-27b could be an important messaging molecule altered by anti-inflammatory drugs that relates to the processing of positive or negative valenced information.

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Section: Discussionsupporting

confidence: 91%

Neuronally-Enriched Exosomal miR-27b Reveals Mechanism for Ibuprofen-Induced Acute Effects on Reward-Related Brain Processing in a Randomized, Placebo-Controlled, Double-Blind Trial

Burrows

Figueroa-Hall

Kuplicki

et al. 2021

Preprint

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“…In contrast to the Motivation and Pleasure Scale–Self-Report (MAP-SR; Llerena et al, 2013 ), a self-report measure of negative symptoms created based on the Clinical Assessment Interview for Negative Symptoms (Forbes et al, 2010 ), the DARS is not focused on schizophrenia. Clinically, the DARS is most frequently used in depression research (Rizvi et al, 2015 ; Dhami et al, 2019 , 2020 ; Bibi et al, 2020 ; Dunlop et al, 2020 ). However, due to its comprehensive design it can be applied in a wide range of contexts, in participants from healthy and diverse clinical populations.…”

Section: Discussionmentioning

confidence: 99%

State Anhedonia in Young Healthy Adults: Psychometric Properties of the German Dimensional Anhedonia Rating Scale (DARS) and Effects of the COVID-19 Pandemic

2021

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Healthy reward processing is a complex interplay of several components. Recent self-report measures of anhedonia, the decrease or loss of hedonic capacity, take this complexity into account. The Dimensional Anhedonia Rating Scale (DARS) measures interest, motivation, effort and consummatory pleasure across four domains: hobbies, food/drink, social activities and sensory experiences. In the present cross-sectional survey study, we validated the German version of the DARS in a sample of 557 young healthy adults. Factor structure as well as convergent and divergent validity were assessed. As a secondary aim, we examined the effects of the COVID-19 pandemic on state anhedonia and depression severity. Our results suggest good convergent and divergent validity and high internal consistency of the German DARS. The original differentiation of four factors mapping onto the four domains was confirmed and measurement invariance before and during the COVID-19 pandemic was established. We conclude that the DARS is a valid instrument to comprehensively assess state anhedonia in healthy German samples. Future studies should further assess the utility of the German DARS in clinical contexts. In line with many previous studies, participants during the pandemic reported significantly higher levels of depressive symptoms compared to participants in the months before. We found no indication that the COVID-19 pandemic affected state hedonic capacity.

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“…The MID task has been used extensively to examine reward and loss related processing in individuals with mood or anxiety disorders 32 . Specifically, individuals with depression show an attenuation of reward-related anticipation during an episode 33 but not when remitted 34 and may normalize after treatment 35 . Moreover, increased levels of peripheral inflammatory markers are associated with relatively lower reward-related activation 36 , which is consistent with the view that inflammatory cytokines adversely affect positive valence processing 31 .…”

Section: Discussionmentioning

confidence: 99%

Neuronally-enriched exosomal microRNA-27b mediates acute effects of ibuprofen on reward-related brain activity in healthy adults: a randomized, placebo-controlled, double-blind trial

Burrows

Figueroa-Hall

Kuplicki

et al. 2022

Sci Rep

View full text Add to dashboard Cite

This double-blind, randomized, within-subjects design evaluated whether acute administration of an anti-inflammatory drug modulates neuron-specific, inflammation-modulating microRNAs linked to macroscopic changes in reward processing. Twenty healthy subjects (10 females, 10 males) underwent a functional magnetic resonance imaging scan while performing a monetary incentive delay (MID) task and provided blood samples after administration of placebo, 200 mg, or 600 mg of ibuprofen. Neuronally-enriched exosomal microRNAs were extracted from serum and sequenced. Results showed that: (1) 600 mg of ibuprofen exhibited higher miR-27b-3p, miR-320b, miR-23b and miR-203a-3p expression than placebo; (2) higher mir-27b-3p was associated with lower insula activation during MID loss anticipation; and (3) there was an inverse relationship between miR-27b-3p and MID gain anticipation in bilateral putamen during placebo, a pattern attenuated by both 200 mg and 600 mg of ibuprofen. These findings are consistent with the hypothesis that miR-27b could be an important messaging molecule that is associated with regulating the processing of positive or negative valenced information.

show abstract

Clinical, behavioral, and neural measures of reward processing correlate with escitalopram response in depression: a Canadian Biomarker Integration Network in Depression (CAN-BIND-1) Report

Cited by 31 publications

References 52 publications

Neuronally-Enriched Exosomal miR-27b Reveals Mechanism for Ibuprofen-Induced Acute Effects on Reward-Related Brain Processing in a Randomized, Placebo-Controlled, Double-Blind Trial

Neuronally-Enriched Exosomal miR-27b Reveals Mechanism for Ibuprofen-Induced Acute Effects on Reward-Related Brain Processing in a Randomized, Placebo-Controlled, Double-Blind Trial

State Anhedonia in Young Healthy Adults: Psychometric Properties of the German Dimensional Anhedonia Rating Scale (DARS) and Effects of the COVID-19 Pandemic

Neuronally-enriched exosomal microRNA-27b mediates acute effects of ibuprofen on reward-related brain activity in healthy adults: a randomized, placebo-controlled, double-blind trial

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