Clinical attributes and surgical outcomes of angiocentric gliomas

Angiocentric glioma with MYB-QKI fusion located in the brainstem, rather than cerebral cortex

“…Since its initial description by Wang et al in 2005, fewer than 100 cases have been reported, nearly all of which were epilepsy-associated tumors located in the cerebral cortex [1, 8]. Recently, an in-frame MYB - QKI gene fusion was identified as the defining genetic alteration in the majority of tumors pathologically classified as angiocentric gliomas [2, 6].…”

A malignant astrocytoma with uncommon angiocentric features and dot-like EMA expression

“…Most of them had atypical histopathological findings like pleomorphism, mitotic activity, or high Ki-67 index and angiocentric pattern with ependymal differentiation. Three cases progressed to high-grade glioma without AG features [ 4 , 7 , 8 , 11 ]. Two cases of high-grade gliomas with angiocentric features have been described [ 7 , 8 ].…”

“…AGs grow slowly and display characteristic angiocentric structures composed of bipolar, spindled cells with no atypia and ependymal differentiation [ 2 – 5 ]. AGs are considered curable with surgery; however, there were seven tumour recurrences from approximately one hundred tumours with angiocentric pattern described in the literature [ 4 ].…”

Uncommon low-grade brain tumors

“…They are usually located in the frontal and temporal lobes but have been reported in the midbrain, hippocampus, and amygdala. 20 The most common presentation is epilepsy (up to 88%) followed by headache and visual symptoms. 20 MRI shows a well-demarcated, non-enhancing lesion, hyperintense on T2W and hypointense on T1W.…”

“…20 The most common presentation is epilepsy (up to 88%) followed by headache and visual symptoms. 20 MRI shows a well-demarcated, non-enhancing lesion, hyperintense on T2W and hypointense on T1W. There is a characteristic T1W hyperintense rim and stalk-like extension toward the ventricles.…”