Clinical Assessment of 31 Patients With Wilson's Disease

Frequency-dependent changes in the amplitude of low-frequency fluctuations in patients with Wilson’s disease: a resting-state fMRI study

“…The results were consistent with previous MRI studies investigating structural changes in WD patients (Magalhaes et al 1994; Starosta-Rubinstein et al 1987), which showed that most obvious lesions were seen in the basal ganglia, and generalized brain atrophy was also common. Because the GM atrophy may lead to artificial reduction in regional ALFF results, all the functional results in the current study have been adjusted with GM correction.…”

Frequency-dependent changes in the amplitude of low-frequency fluctuations in patients with Wilson’s disease: a resting-state fMRI study

“…The results were consistent with previous MRI studies investigating structural changes in WD patients (Magalhaes et al 1994; Starosta-Rubinstein et al 1987), which showed that most obvious lesions were seen in the basal ganglia, and generalized brain atrophy was also common. Because the GM atrophy may lead to artificial reduction in regional ALFF results, all the functional results in the current study have been adjusted with GM correction.…”

Altered static and dynamic regional homogeneity in basal ganglia–thalamocortical circuits and their association with neuropsychiatric manifestations in Wilson’s disease

“…These regions form a core circuit supporting motor control, emotion regulation, and executive function, while the thalamus acts as a central integrative hub for distributed brain networks ( Alexander and Crutcher, 1990 ; Wichmann and DeLong, 2016 ; Shine et al, 2023 ). Consistent with prior structural and pathological evidence of basal ganglia and thalamic vulnerability in WD ( Starosta-Rubinstein et al, 1987 ; King et al, 1996 ), our findings further demonstrate that functional disruption of these hubs is closely linked to clinical severity. The observed correlations between putaminal ReHo and neurological impairment and disease duration suggest a progression-related shift from functional disruption toward maladaptive or compensatory reorganization, although causal inference is limited by the cross-sectional design.…”

Wilson's disease in southern Brazil: a 40-year follow-up study

“…The mean age at diagnosis is similar to the ones described previously by other authors 12–14. There are, however, reports of onset of symptoms on the extremes of age 15,16.…”

Frequency-dependent changes in the amplitude of low-frequency fluctuations in patients with Wilson’s disease: a resting-state fMRI study

“…The results were consistent with previous MRI studies investigating structural changes in WD patients (Magalhaes et al 1994; Starosta-Rubinstein et al 1987), which showed that most obvious lesions were seen in the basal ganglia, and generalized brain atrophy was also common. Because the GM atrophy may lead to artificial reduction in regional ALFF results, all the functional results in the current study have been adjusted with GM correction.…”

Altered static and dynamic regional homogeneity in basal ganglia–thalamocortical circuits and their association with neuropsychiatric manifestations in Wilson’s disease

“…These regions form a core circuit supporting motor control, emotion regulation, and executive function, while the thalamus acts as a central integrative hub for distributed brain networks ( Alexander and Crutcher, 1990 ; Wichmann and DeLong, 2016 ; Shine et al, 2023 ). Consistent with prior structural and pathological evidence of basal ganglia and thalamic vulnerability in WD ( Starosta-Rubinstein et al, 1987 ; King et al, 1996 ), our findings further demonstrate that functional disruption of these hubs is closely linked to clinical severity. The observed correlations between putaminal ReHo and neurological impairment and disease duration suggest a progression-related shift from functional disruption toward maladaptive or compensatory reorganization, although causal inference is limited by the cross-sectional design.…”

Wilson's disease in southern Brazil: a 40-year follow-up study

“…The mean age at diagnosis is similar to the ones described previously by other authors 12–14. There are, however, reports of onset of symptoms on the extremes of age 15,16.…”

Frequency-dependent changes in the amplitude of low-frequency fluctuations in patients with Wilson’s disease: a resting-state fMRI study

“…The results were consistent with previous MRI studies investigating structural changes in WD patients (Magalhaes et al 1994; Starosta-Rubinstein et al 1987), which showed that most obvious lesions were seen in the basal ganglia, and generalized brain atrophy was also common. Because the GM atrophy may lead to artificial reduction in regional ALFF results, all the functional results in the current study have been adjusted with GM correction.…”

Altered static and dynamic regional homogeneity in basal ganglia–thalamocortical circuits and their association with neuropsychiatric manifestations in Wilson’s disease

“…These regions form a core circuit supporting motor control, emotion regulation, and executive function, while the thalamus acts as a central integrative hub for distributed brain networks ( Alexander and Crutcher, 1990 ; Wichmann and DeLong, 2016 ; Shine et al, 2023 ). Consistent with prior structural and pathological evidence of basal ganglia and thalamic vulnerability in WD ( Starosta-Rubinstein et al, 1987 ; King et al, 1996 ), our findings further demonstrate that functional disruption of these hubs is closely linked to clinical severity. The observed correlations between putaminal ReHo and neurological impairment and disease duration suggest a progression-related shift from functional disruption toward maladaptive or compensatory reorganization, although causal inference is limited by the cross-sectional design.…”

Wilson's disease in southern Brazil: a 40-year follow-up study

“…The mean age at diagnosis is similar to the ones described previously by other authors 12–14. There are, however, reports of onset of symptoms on the extremes of age 15,16.…”