Clinical Assessment and Management of Toddlers With Suspected Autism Spectrum Disorder: Insights From Studies of High-Risk Infants

Zwaigenbaum, Lonnie; Bryson, Susan E.; Lord, Catherine; Rogers, Sally J.; Carter, Alice S.; Carver, Leslie J.; Chawarska, Kasia; Constantino, John N.; Dawson, Geraldine; Dobkins, Karen R.; Fein, Deborah; Iverson, Jana M.; Klin, Ami; Landa, Rebecca; Messinger, Daniel S.; Ozonoff, Sally J; Sigman, Marian; Stone, Wendy L.; Tager–Flusberg, Helen; Yirmiya, Nurit

doi:10.1542/peds.2008-1606

Cited by 356 publications

(291 citation statements)

References 99 publications

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“…[35][36][37][38] The red flags identified should be followed by immediate referral for infant intervention rather than adopting a "wait-andsee" attitude because early specialized intervention is considered best practice for ASD 39,40 and may represent the best hope for reducing symptoms and overall disability in high-risk infants who are developing ASD. 41 …”

Section: Discussionmentioning

confidence: 99%

Recurrence Risk for Autism Spectrum Disorders: A Baby Siblings Research Consortium Study

et al. 2011

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WHAT'S KNOWN ON THIS SUBJECT:The sibling recurrence risk of autism has been estimated to be between 3% and 10%. Previous research was affected by small samples and selection, stoppage, and reporting limitations. Updated estimates of recurrence risk are needed. WHAT THIS STUDY ADDS:Studying a large sample and using a prospective longitudinal design, this study demonstrated that the sibling recurrence risk of autism spectrum disorder is substantially higher than previous estimates. This elevated risk has important implications for infant screening and genetic counseling. abstract OBJECTIVE: The recurrence risk of autism spectrum disorders (ASD) is estimated to be between 3% and 10%, but previous research was limited by small sample sizes and biases related to ascertainment, reporting, and stoppage factors. This study used prospective methods to obtain an updated estimate of sibling recurrence risk for ASD. METHODS:A prospective longitudinal study of infants at risk for ASD was conducted by a multisite international network, the Baby Siblings Research Consortium. Infants (n ϭ 664) with an older biological sibling with ASD were followed from early in life to 36 months, when they were classified as having or not having ASD. An ASD classification required surpassing the cutoff of the Autism Diagnostic Observation Schedule and receiving a clinical diagnosis from an expert clinician. RESULTS:A total of 18.7% of the infants developed ASD. Infant gender and the presence of Ͼ1 older affected sibling were significant predictors of ASD outcome, and there was an almost threefold increase in risk for male subjects and an additional twofold increase in risk if there was Ͼ1 older affected sibling. The age of the infant at study enrollment, the gender and functioning level of the infant's older sibling, and other demographic factors did not predict ASD outcome. CONCLUSIONS:The sibling recurrence rate of ASD is higher than suggested by previous estimates. The size of the current sample and prospective nature of data collection minimized many limitations of previous studies of sibling recurrence. Clinical implications, including genetic counseling, are discussed. Pediatrics 2011;128:e488-e495 AUTHORS:

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Section: Discussionmentioning

confidence: 99%

Recurrence Risk for Autism Spectrum Disorders: A Baby Siblings Research Consortium Study

et al. 2011

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“…7 However, late identification of ASD is a wellknown problem, even in developed countries. 8 A recent review article including data from 42 studies (from 1990 to 2012) showed that the mean age of ASD diagnosis ranged from 38 to 120 months.…”

Section: Discussionmentioning

confidence: 99%

Impact of training in autism for primary care providers: a pilot study

Bordini

Lowenthal

Gadelha

et al. 2014

Rev. Bras. Psiquiatr.

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Objective: To evaluate the impact of a training program on autism spectrum disorder (ASD) identification offered to Brazilian health professionals. Methods: Twenty-two primary care providers participated in five 3-hour weekly training sessions. Results: The trained providers significantly improved their ASD knowledge after training in comparison with pre-training (mean score, 6.73 vs. 9.18, p , 0.01). Clinical practice also changed: 4 months after the training program, the providers had referred six times as many suspected cases of ASD to a specialized mental health service in comparison with the previous 4 months. Conclusion: This pilot training model seems a promising, feasible, and inexpensive way to improve early identification of ASD in the primary care system.

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“…Além disso, estudos prospectivos realizados com irmãos de indivíduos com TEA, cujo risco estimado de também apresentarem o transtorno é de 5 a 10% (Rice et al, 2007), têm identificado diversos comportamentos manifestados entre 12 e 18 meses, que distinguem os bebês com TEA de outros com desenvolvimento típico (Zwaigenbaum et al, 2009).…”

Section: Discussionunclassified

Identificação dos primeiros sintomas do autismo pelos pais

Zanon

Backes

Bosa

2014

Psic.: Teor. e Pesq.

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RESUMO -Dificuldades no desenvolvimento social são os indicadores mais prováveis de um futuro diagnóstico de autismo, entretanto o atraso da fala parece ser o motivo que mais mobiliza os pais na busca por assistência. Neste estudo foram investigados os primeiros sintomas percebidos pelos pais de crianças com autismo e a idade da criança na ocasião. Participaram 32 pré-escolares e o instrumento utilizado foi a Autism Diagnostic Interview-Revised. Comprometimentos no desenvolvimento da linguagem foram os sintomas mais frequentemente observados, porém os da socialização foram os mais precocemente identificados. No geral, a idade média em que os primeiros sintomas foram percebidos foi 15,2 meses. Os resultados corroboram achados de outros estudos, ressaltando a importância dos comprometimentos sociais para a identificação precoce do autismo. Palavras-chave: autismo, identificação precoce, percepção dos pais Parents' Perception of the First Symptoms of AutismABSTRACT -The occurrence of problems related to social development is the best predictors of a future diagnosis of an Autistic Disorder. Speech delay, however, seems to be the main that reason that leads parents to seek assistance. The present study aimed to investigate the first symptoms observed by the parents of children with autism and the age that it occurred. Thirty-two preschool children participated in the study. The instrument used was the Autism Diagnostic Interviwed-Revised. Abnormalities in language development were the most frequent symptoms reported by the parents, but social impairment was the earliest that was noticed. The average age when the parents noticed the first symptoms was 15.2 months. The results corroborate other findings, highlighting the importance of social deficits for the early identification of autism.

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Clinical Assessment and Management of Toddlers With Suspected Autism Spectrum Disorder: Insights From Studies of High-Risk Infants

Cited by 356 publications

References 99 publications

Recurrence Risk for Autism Spectrum Disorders: A Baby Siblings Research Consortium Study

Recurrence Risk for Autism Spectrum Disorders: A Baby Siblings Research Consortium Study

Impact of training in autism for primary care providers: a pilot study

Identificação dos primeiros sintomas do autismo pelos pais

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